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Gel hemostatic material composition and preparation method thereof

A hemostatic material and gel technology, applied in the field of gel hemostatic material and its preparation, can solve the problems of difficult to control gel time, large tissue irritation, weak bonding strength and the like, and achieve high strength, fast gel speed, The effect of low expansion

Active Publication Date: 2015-03-11
沈伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bonding strength of these two materials is weak, which cannot meet the requirements of practical application, and Coseal sealant has a strong irritating odor, and after Duraseal sealant is gel-like, the pH of the gel is alkaline, which is harmful to tissue High irritation, and the gel time of the product is difficult to control
Hydrogel products with a single nucleophilic or electrophilic component cannot meet the requirements of different physical properties such as gelation speed, viscosity, low swelling, and degradation time, and it is necessary to improve

Method used

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  • Gel hemostatic material composition and preparation method thereof
  • Gel hemostatic material composition and preparation method thereof
  • Gel hemostatic material composition and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0053] 1) Preparation of the sample to be tested: dissolve the solid powder obtained in step (1) of the preparation method of the gel hemostatic material in an acidic buffer solution with a pH of 3.5-6.0 to obtain a solution (D), and transfer the solution (D) into one syringe of the two-component mixer, then transfer the alkaline buffer solution (E) with a pH of 9.0-10.2 to another syringe, and install the two-component mixer for use.

[0054] 2) Detection of gelation time (s): Push the two-component mixer evenly. After the solution (D) and buffer solution (E) are mixed by the two-component mixer, they are sprayed onto the watch glass and start timing at the same time until The time until the gel is completely formed (no flowing liquid) is recorded as the gel-forming time.

[0055] Swelling rate (%) detection:

[0056] Swelling rate refers to the percentage of mass increase when the hydrogel is swollen and saturated in PBS solution after effective cross-linking. Its detectio...

Embodiment 1

[0075]Weigh 4-arm-PEG-SG (purchased from Shanghai Xibao Biotechnology Co., Ltd., Mn=10000) and 4-arm-PEG-NH2 (purchased from Shanghai Xibao Biotechnology Co., Ltd., Mn=10000), 4 -arm-PEG-SH (purchased from Shanghai Xibao Biotechnology Co., Ltd., Mn=10000) and trimeric lysine acetate (purchased from Jill Biochemical (Shanghai) Co., Ltd.) were put into 1 mL of phosphoric acid with pH=3.7 Sodium buffer (concentration: 0.02M), shake to dissolve completely, and draw it into the syringe with a blue syringe. Use a pink syringe to draw 1mL of borax buffer solution with pH=9.8 (concentration: 0.065M), install the two syringes on the two-component mixer, install the nozzle, push the two-component mixer, the liquid in the two syringes The hydrogel can be quickly formed after being mixed by a two-component mixer.

[0076] According to the gelation time (s) detection method, swelling rate (%) detection method, burst strength (mmHg) detection method, bonding performance detection method an...

Embodiment 2

[0081] Weigh 4-arm-PEG-SG (purchased from Shanghai Xibao Biotechnology Co., Ltd., Mn=10000) and 4-arm-PEG-NH2 (purchased from Shanghai Xibao Biotechnology Co., Ltd., Mn=10000), 4 -arm-PEG-SH (purchased from Shanghai Xibao Biotechnology Co., Ltd., Mn=10000) and trimeric lysine acetate (purchased from Jill Biochemical (Shanghai) Co., Ltd.) were put into 1 mL of phosphoric acid with pH=3.7 Sodium buffer (concentration: 0.02M), shake to dissolve completely, and draw it into the syringe with a blue syringe. Use a pink syringe to draw 1mL of borax buffer solution with pH=9.8 (concentration: 0.065M), install the two syringes on the two-component mixer, install the nozzle, push the two-component mixer, the liquid in the two syringes The hydrogel can be quickly formed after being mixed by a two-component mixer.

[0082] According to the gelation time (s) detection method, swelling rate (%) detection method, burst strength (mmHg) detection method, bonding performance detection method a...

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Abstract

The invention relates to a gel hemostatic material and a preparation method thereof. The gel hemostatic material achieves the effect of blocking hemostasis in such a way that a nucleophilic polymer and an amino acid oligomer are in cross-linking reaction with an electrophile polymer to generate a three-dimensional polymer in situ. A gel hemostatic material composition and a preparation method thereof have the advantages that the raw material ratio is controlled accurately, the reasonable gel forming time can be achieved, the gel forming time is less than 10 seconds, the expected strength is relatively high, and the testing result shows that the elongation at break of the biologic gel hemostatic material is 300-600 percent, and the compression strength of the biologic gel hemostatic material is larger than 3 Mpa; the requirement of surgical operation can be met well.

Description

technical field [0001] The invention belongs to the technical field of biological gel materials, and relates to a gel hemostatic material and a preparation method thereof. The hemostatic material of the present application has reasonable gelation time and expected mechanical properties. Background technique [0002] In surgical operations, rapid, effective and safe hemostasis is one of the key factors to ensure the success of the operation. Excellent hemostatic materials can control wound bleeding, ensure clear surgical field of view, improve surgical efficiency, and accelerate postoperative recovery of patients. A variety of hemostatic materials have been developed at home and abroad, mainly including bone wax used in early clinical practice, fibrin, cyanoacrylate, glutaraldehyde cross-linked albumin widely used in clinical practice, and new polyethylene glycol recently used. alcohol hydrogel, etc. Bone wax is a hemostatic material used early in clinical practice. It has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/20A61L15/24C08J3/24C08J3/075
Inventor 沈伟于树芳徐景海
Owner 沈伟
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