Silicone hydrogel contact lens

A contact lens and silicon hydrogel technology, applied in the direction of instruments, optics, optical components, etc., can solve the problems that polarographic technology cannot provide measured values, glasses are not very wettable, and glasses are stiff

Inactive Publication Date: 2008-04-16
COOPERVISION INT HLDG CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for high Dk silicone hydrogel contact lenses (e.g., silicone hydrogel contact lenses with a Dk greater than about 100 barrer), the polarographic technique does not appear to provide accurate measurements
Variability associated with polarographic techniques may relate to the problem that measurements tend to stagnate at Dk values ​​greater than 100 for silicone hydrogel lenses with a Dk greater than 100 barrer
In addition, these glasses are stiffer than glasses with higher water content and these glasses are less wettable

Method used

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Examples

Experimental program
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preparation example Construction

[0108] An example of a useful synthetic method includes the step of reacting cyclic siloxanes having hydrosilyl groups (Si—H), cyclic siloxanes having hydrocarbyl Mixtures of siloxanes and disiloxanes having hydroxyalkyl groups at both ends and (in some cases) cyclic siloxanes having fluorine-substituted hydrocarbyl groups are subjected to ring-opening polymerization to obtain A hydrosilyl group-containing polysiloxane compound having a hydroxyl group. In this case, silicon with various degrees of polymerization and introduction ratios of fluorine-containing substituents to hydrosilyl groups can be obtained by changing the feeding ratio of each cyclic siloxane to disiloxane compound used. Oxygen compounds.

[0109] Isocyanato-substituted acrylates or isocyanato-substituted methacrylates are then reacted with hydroxyl groups at the end of the polysiloxane to obtain urethane-containing fluorinated urethanes with polymerizable unsaturated groups at both ends. Silicone compounds...

example

[0156] The following non-limiting examples illustrate various aspects and features of the invention.

Synthetic example 1

[0158] [Synthesis of polysiloxane diol (A1) having a hydrosilyl group]

[0159]At 25°C, 150 grams of octamethylcyclotetrasiloxane, 22.6 grams of 1,3,5-trimethyltrifluoropropyl-cyclotrisiloxane, 5.2 grams of 1,3,5,7-tetra Methyl-cyclotetrasiloxane, 9.8 grams of 1,3-bis(3-(2-hydroxyethoxy)propyl)tetramethyldisiloxane, 200 grams of chloroform and 1.5 grams of trifluoromethanesulfonic acid The mixture was stirred for 24 hours, followed by repeated washing with purified water until the pH of the mixture became neutral. After separating water, chloroform was distilled off under reduced pressure. The residual liquid was dissolved in acetone (36 g), reprecipitated with methanol (180 g), and the volatile components were removed from the separated liquid under vacuum to afford a clear viscous liquid. The liquid was siloxanediol (H3R) having a hydrosilyl group represented by the following formula, and the yield thereof was 125 g. Here, although the structural formula of the linker Y i...

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Abstract

Ophthalmically compatible contact lenses include lens bodies configured for placement on a cornea of an animal or human eye. The lens bodies are made of a hydrophilic silicon-containing polymeric material. The lens bodies have oxygen permeabilities, water content, surface wettabilities, flexibilities, and / or designs to be worn by a lens wearer even during sleep. The present lenses can be worn on a daily basis, including overnight, or can be worn for several days, such as about thirty days, without requiring removal or cleaning.

Description

[0001] Inventors: Junichi Iwata, Tsuneo Hoki, Seiichirou Ikawa, and Arthur Back [0002] Cross References to Related Applications [0003] This application claims the benefit of U.S. Provisional Application No. 60 / 604,961, filed August 27, 2004, and U.S. Provisional Application No. 60 / 621,525, filed October 22, 2004, the contents of which are reproduced in their entirety Incorporated herein by reference. technical field [0004] The present invention relates to a contact lens that can be worn continuously for a long time. Specifically, the present invention relates to flexible, hydrophilic silicon-containing contact lenses having an advantageous combination of properties. Background technique [0005] Contact lenses are basically classified into soft type and hard type glasses. Hard contact lenses are literally hard and may be slightly uncomfortable to wear. Soft contact lenses, on the other hand, are more comfortable to wear but are usually removed from the eye at the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B1/04C08F290/06
Inventor 岩田淳一保木恒夫井川诚一郎阿瑟·巴克
Owner COOPERVISION INT HLDG CO
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