The invention relates to an anti-interference electrochemical sensor based on a differential
signal and an MOFs
molecular sieve and a preparation method. The anti-interference electrochemical sensor comprises a first
working electrode, a second
working electrode, a
reference electrode and a counter
electrode, wherein the surface of the first
working electrode is modified with a first functional material, and the first functional material is used for performing non-selective electro-
catalysis on a target object and an interferent to generate a
total response signal; the surface of the second working
electrode is modified with a second functional material, and the second functional material is used for physically screening the target object according to the
molecular size, allowing the interferent to pass through and performing electro-
catalysis on the interferent to generate an interferent response
signal; wherein the second functional material comprises a
metal organic framework material; and performing differential operation on the
total response signal and the interferent response signal to obtain a target object response signal. According to the sensor, accurate stripping of interference signals is achieved, intrinsic response only related to the concentration of a target object is obtained, and accurate
interference resistance from the source is achieved.