Multi-reflecting time-of-flight mass spectrometer and a method of use

Abstract

A multi-reflection time-of-flight mass spectrometer (MR-TOFMS) and an analysis method are disclosed. The flight paths of the ions are folded along a trajectory through electrostatic mirrors. Longer flight paths provide higher resolution while maintaining a modest instrument size.

Description

technical field [0001] The present invention generally relates to the field of mass spectrometry, and more particularly to a multi-reflection time-of-flight mass spectrometer (MR-TOF MS) and a method of use. Background technique [0002] Mass spectrometry is a well-established tool in analytical chemistry for the identification and quantification of various compounds and mixtures. The sensitivity and resolution of this analysis are critical for practical use. It is well established that the resolution of TOF MS is directly proportional to the length of the flight path. However, it has been recognized that increasing the flight path while keeping the instrument at a reasonable size is difficult. The proposed solution is a multiple reflection time-of-flight mass spectrometer (MR-TOF MS). The use of MR-TOF MS became possible after the introduction of an electrostatic ion mirror with time-of-flight focusing properties. US Patent No. 4,072,862, USSR Patent No. SU198034 and So...

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However, this is resolution at the expense of loss of sensitivit

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