The invention relates to a hand-washing-free disinfectant and a preparation method thereof, and belongs to the technical field of hygienic products. In order to solve the problem that an existing hand-washing-free disinfectant easily stimulates skin and causes skin moisture loss, the hand-washing-free disinfectant is provided and comprises, by mass, 60-80 parts of absolute ethyl alcohol, 10-30 parts of purified water, 0.1-2.0 parts of thickening agents, 1-10 parts of glycerin, 0.01-1 part of plant essential oil and 0.1-5 parts of ginger extracts. The hand-washing-free disinfectant further comprises 0.1-2 parts of chlorhexidine gluconate or chlorhexidine acetate and 0.1-2 parts of sodium hyaluronate. According to the hand-washing-free disinfectant, various raw materials are mixed and matched, a scientific formula is achieved, the raw materials complement each other's advantages, hand disinfection is achieved by the aid of the synergistic effect of the raw materials, hand skin can be prevented from being dry, the pH (potential of hydrogen) value is close to that of the skin, and the disinfectant is non-toxic and non-irritant to the skin, safe, efficient, portable and convenient to apply.