The invention discloses a novel efficient automatic indoor air purification device and belongs to the technical field of environment-friendly air purification. The indoor air purification device specifically comprises a shell, a circuit board, an air guiding device, an air dust collection device, a negative ion generation device, an ultraviolet sterilization device, a photocatalytic oxidation device, an operation panel and a wireless remote controller, wherein a draught fan serves as a power source of the air guiding device. A negative ion technology, an ultraviolet sterilization technology, a photocatalytic oxidation technology, a silver ion sterilization technology and a filtering adsorption technology are integrated. The shortages that according to an existing air purification device, the functions of sterilization, disinfection and removal of suspended particles, volatile harmful gases, peculiar smells, ozone and other harmful gases are single or the removal effect is poor, energy consumption is large, secondary pollution is caused, cost is high, and the environment-friendly performance is poor are overcome. The novel efficient automatic indoor air purification device is complete in air purification and disinfection effect, simple in structure, high in efficiency, low in energy consumption and noise, capable of saving maintenance cost, long in service life and capable of being practically applied to various indoor environments such as medical treatment institutions, enterprise and public institutions, public occasions, storerooms, workshops and houses.