Artegenin and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to an artemisinin, which comprises the following components: 30% of sweet wormwood, 40% of mugwort and 30% of artemisia stelleriana. The invention further provides a preparation method of the three-artein, which comprises the following steps: S11, preparing the sweet wormwood, the mugwort and the artemisia stelleriana, and cleaning the sweet wormwood, the mugwort and the artemisia stelleriana; s12, juice in the sweet wormwood, the mugwort and the artemisia stelleriana is squeezed out in a liquid squeezing mode; s13, filtering the juice, washing the filtered and intercepted leaf residues and stalk residues with purified water during filtering, and then precipitating the filtered juice to remove fine precipitates; and S14, adding the juice obtained in the step S13 into purified water with the same proportion, and stirring and mixing. The multifunctional air purifying agent has the effects of purifying air, improving various peculiar smells in space, repelling mosquitoes and disinfecting.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to artemisinin and a preparation method thereof. Background Art

[0002] Artemisinin is a compound extracted and separated from the leaves of the Asteraceae plant Artemisia annua. It is widely used in the treatment of various diseases, the most important of which is malaria. The existing artemisinin is of a single type, and the content is mainly artemisinin, which is mainly used in medicine and cannot be used in daily life, affecting the scope of artemisinin use. In order to solve this problem, we proposed a triartemisinin and a preparation method thereof, so that artemisinin can be used in daily life. Summary of the invention

[0003] The purpose of the present invention is to solve the shortcomings of the prior art that artemisinin cannot be used in daily life, which affects the scope of use of artemisinin, and to propose a triartemisinin and a preparation method thereof.

[0004] In order to achieve the above object, the present invention adopts the following technical solutions:

[0005] A triple artemisinin is designed, comprising the following ingredients: 30% Artemisia annua, 40% Artemisia argyi, and 30% Artemisia argyi.

[0006] The present invention also provides a method for preparing artemisinin, comprising the following steps:

[0007] S11, preparing Artemisia annua, Artemisia argyi and Artemisia argyi, and cleaning them;

[0008] S12, squeezing out the juice from the Artemisia annua, Artemisia argyi and Artemisia argyi by squeezing liquid;

[0009] S13, filtering the juice, while using pure water to rinse the leaf residue and stem residue intercepted by the filter, and then precipitating the filtered juice to remove fine sediment;

[0010] S14, adding the juice obtained in step S13 into purified water of the same specific gravity and stirring and mixing;

[0011] S15, adding 50% alcohol to precipitate fats, proteins and sugars in the plants, filtering the precipitated substances by ultrafiltration, and purifying the liquid;

[0012] S16, bottling the purified raw liquid and storing it in storage.

[0013] Preferably, during the squeezing, the Artemisia leaves and Artemisia stems are separated and squeezed separately by using an squeezing machine, the Artemisia leaves are squeezed 2-3 times, and the Artemisia stems are squeezed 3-4 times;

[0014] Preferably, the method comprises the following steps:

[0015] S21, preparing Artemisia annua, Artemisia argyi and Artemisia scoparia, washing Artemisia annua, Artemisia argyi and Artemisia scoparia, and chopping Artemisia annua, Artemisia argyi and Artemisia scoparia;

[0016] S22, putting the chopped Artemisia annua, Artemisia argyi and Artemisia argyi into a distiller, controlling the temperature of the distiller to be 110-116° C. for 2-4 hours;

[0017] S22, condensing and collecting the steam as raw materials;

[0018] S23, mixing the raw material and purified water in a proportioned manner, detecting the pH value of the raw material, and adjusting the pH value;

[0019] S24, conduct bacterial culture test on the prepared raw materials, adjust the fragrance of the raw materials and then bottle them.

[0020] Preferably, when performing the aroma adjustment treatment, the spices are added while controlling the temperature to 30-40°C, the time is 5-10min, stirred for 1-2min, and then the temperature is raised to 50-55°C, stirred for 2-3min, and then cooled to room temperature.

[0021] Preferably, the fragrance is prepared by removing impurities from mint and lavender flowers, soaking them in pure water at 50-60°C, then crushing them, adding them to pure water for distillation, and cooling the distillate extracted after distillation to make the fragrance.

[0022] Preferably, when adjusting the pH value, the pH value is controlled at 6.4-7.0.

[0023] The invention provides a kind of artemisinin and its preparation method, which has the beneficial effects that: mugwort contains volatile oil, flavonoid compounds, terpene compounds; Artemisia annua contains volatile components, olefin components, artemisinine, and artemisinin; white wormwood contains volatile oil, flavonoid compounds, fragrance, and mosquito repellent. It can purify the air, improve various odors in the space, and at the same time has the effect of mosquito repellent and disinfection. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0025] Example 1: A triartemisinin: comprising the following ingredients: 30% Artemisia annua, 40% Artemisia argyi, 30% Artemisia argyi, Artemisia annua contains volatile oil, flavonoids, terpenes; Artemisia annua contains volatile components, olefins, artemisinine, and artemisinin; Artemisia argyi contains volatile oil, flavonoids, fragrance, and mosquito repellent. It can purify the air, improve various odors in the space, and has the effect of repelling mosquitoes and insects, and also has the effect of disinfection.

[0026] The present invention also provides a method for preparing artemisinin, comprising the following steps:

[0027] S11, preparing Artemisia annua, Artemisia argyi and Artemisia argyi, and cleaning them;

[0028] S12, squeezing out the juice from the Artemisia annua, Artemisia argyi and Artemisia argyi by squeezing liquid;

[0029] S13, filtering the juice, while using pure water to rinse the leaf residue and stem residue intercepted by the filter, and then precipitating the filtered juice to remove fine sediment;

[0030] S14, adding the juice obtained in step S13 into purified water of the same specific gravity and stirring and mixing;

[0031] S15, adding 50% alcohol to precipitate fats, proteins and sugars in the plants, filtering the precipitated substances by ultrafiltration, and purifying the liquid to precipitate impurities therein, achieving a purification effect;

[0032] S16, bottling the purified raw liquid and storing it in storage.

[0033] When squeezing, the Artemisia leaves and Artemisia stems are separated and squeezed separately by using an extruder. The Artemisia leaves are squeezed twice and the Artemisia stems are squeezed three times. The separate squeezing method is beneficial to ensure the squeezing effect of the Artemisia leaves and Artemisia stems.

[0034] Example 2: A triartemisinin: comprising the following ingredients: 30% Artemisia annua, 40% Artemisia argyi, and 30% Artemisia argyi. Artemisia annua contains volatile oil, flavonoids, and terpenes; Artemisia annua contains volatile components, olefins, artemisinine, and artemisinin; Artemisia argyi contains volatile oil, flavonoids, fragrance, and mosquito repellent. It can purify the air, improve various odors in the space, and has the effect of repelling mosquitoes and insects, and also has the effect of disinfection.

[0035] The present invention also provides a method for preparing artemisinin, comprising the following steps:

[0036] S11, preparing Artemisia annua, Artemisia argyi and Artemisia argyi, and cleaning them;

[0037] S12, squeezing out the juice from the Artemisia annua, Artemisia argyi and Artemisia argyi by squeezing liquid;

[0038] S13, filtering the juice, while using pure water to rinse the leaf residue and stem residue intercepted by the filter, and then precipitating the filtered juice to remove fine sediment;

[0039] S14, adding the juice obtained in step S13 into purified water of the same specific gravity and stirring and mixing;

[0040] S15, adding 50% alcohol to precipitate fats, proteins and sugars in the plants, filtering the precipitated substances by ultrafiltration, and purifying the liquid;

[0041] S16, bottling the purified raw liquid and storing it in storage.

[0042] When squeezing, the Artemisia leaves and Artemisia stems are separated and squeezed separately by using an extruder. The Artemisia leaves are squeezed 3 times and the Artemisia stems are squeezed 4 times. The separate squeezing method is beneficial to ensure the squeezing effect of the Artemisia leaves and Artemisia stems.

[0043] Example 3: A triartemisinin: comprising the following ingredients: 30% Artemisia annua, 40% Artemisia argyi, and 30% Artemisia argyi. Artemisia annua contains volatile oil, flavonoids, and terpenes; Artemisia annua contains volatile components, olefins, artemisinine, and artemisinin; Artemisia argyi contains volatile oil, flavonoids, fragrance, and mosquito repellent. It can purify the air, improve various odors in the space, and has the effect of repelling mosquitoes and insects, and also has the effect of disinfection.

[0044] A method for preparing artemisinin comprises the following steps:

[0045] S21, preparing Artemisia annua, Artemisia argyi and Artemisia scoparia, washing Artemisia annua, Artemisia argyi and Artemisia scoparia, and chopping Artemisia annua, Artemisia argyi and Artemisia scoparia;

[0046] S22. Put the chopped Artemisia annua, Artemisia argyi and Artemisia sphaerocephala into a distiller, control the temperature of the distiller to 110° C., and the distillation time to 4 hours, so as to extract artemisinin from Artemisia annua, Artemisia argyi and Artemisia sphaerocephala. Meanwhile, the distillation is also conducive to the fusion of the extracts from Artemisia annua, Artemisia argyi and Artemisia sphaerocephala.

[0047] S22, condensing and collecting the steam as raw materials;

[0048] S23, mixing the raw material and purified water in a proportioned manner, detecting the pH value of the raw material, and adjusting the pH value;

[0049] S24, conduct bacterial culture test on the prepared raw materials, adjust the fragrance of the raw materials and then bottle them.

[0050] When adjusting the fragrance, add the fragrance while controlling the temperature at 30°C for 5 minutes and stir for 1 minute. At the end, raise the temperature to 50°C, stir for another 2 minutes, and then cool to room temperature.

[0051] The spices are prepared by removing impurities from mint and lavender flowers, soaking them in 50° C. pure water, then crushing them, adding them into pure water for distillation, and cooling the distillate extracted after distillation to make the spices.

[0052] When adjusting the pH value, control the pH value at 6.4.

[0053] Example 4: A triartemisinin: comprising the following ingredients: 30% Artemisia annua, 40% Artemisia argyi, and 30% Artemisia scoparia. Artemisia scoparia contains volatile oil, flavonoids, and terpenes; Artemisia annua contains volatile components, olefins, artemisinine, and artemisinin; Artemisia scoparia contains volatile oil, flavonoids, fragrance, and mosquito repellent. It can purify the air, improve various odors in the space, and has the effect of repelling mosquitoes and insects, and also has the effect of disinfection.

[0054] A method for preparing artemisinin comprises the following steps:

[0055] S21, preparing Artemisia annua, Artemisia argyi and Artemisia scoparia, washing Artemisia annua, Artemisia argyi and Artemisia scoparia, and chopping Artemisia annua, Artemisia argyi and Artemisia scoparia;

[0056] S22. Put the chopped Artemisia annua, Artemisia argyi and Artemisia sphaerocephala into a distiller, control the temperature of the distiller to 113° C., and extract artemisinin from Artemisia annua, Artemisia argyi and Artemisia sphaerocephala by distillation for 3 hours. Meanwhile, the distillation is also beneficial to the fusion of the extracts from Artemisia annua, Artemisia argyi and Artemisia sphaerocephala.

[0057] S22, condensing and collecting the steam as raw materials;

[0058] S23, mixing the raw material and purified water in a proportioned manner, detecting the pH value of the raw material, and adjusting the pH value;

[0059] S24, conduct bacterial culture test on the prepared raw materials, adjust the fragrance of the raw materials and then bottle them.

[0060] When adjusting the aroma treatment, add the aroma while controlling the temperature at 35°C for 7 minutes and stir for 2 minutes. At the end, raise the temperature to 52°C, stir for 3 minutes, and then cool to room temperature.

[0061] The spices are prepared by removing impurities from mint and lavender flowers, soaking them in pure water at 55°C, then crushing them, adding them into pure water for distillation, and cooling the distillate extracted after distillation to make the spices.

[0062] When adjusting the pH value, control the pH value at 6.7.

[0063] Example 5: A triartemisinin: comprising the following ingredients: 30% Artemisia annua, 40% Artemisia argyi, and 30% Artemisia argyi. Artemisia annua contains volatile oil, flavonoids, and terpenes; Artemisia annua contains volatile components, olefins, artemisinine, and artemisinin; Artemisia argyi contains volatile oil, flavonoids, fragrance, and mosquito repellent. It can purify the air, improve various odors in the space, and has the effect of repelling mosquitoes and insects, and also has the effect of disinfection.

[0064] A method for preparing artemisinin comprises the following steps:

[0065] S21, preparing Artemisia annua, Artemisia argyi and Artemisia scoparia, washing Artemisia annua, Artemisia argyi and Artemisia scoparia, and chopping Artemisia annua, Artemisia argyi and Artemisia scoparia;

[0066] S22. Put the chopped Artemisia annua, Artemisia argyi and Artemisia sphaerocephala into a distiller, control the temperature of the distiller to 116° C., and distill for 4 hours to extract artemisinin from Artemisia annua, Artemisia argyi and Artemisia sphaerocephala. Meanwhile, the distillation is also beneficial to the fusion of the extracts from Artemisia annua, Artemisia argyi and Artemisia sphaerocephala.

[0067] S22, condensing and collecting the steam as raw materials;

[0068] S23, mixing the raw material and purified water in a proportioned manner, detecting the pH value of the raw material, and adjusting the pH value;

[0069] S24, conduct bacterial culture test on the prepared raw materials, adjust the fragrance of the raw materials and then bottle them.

[0070] When adjusting the fragrance, add the fragrance while controlling the temperature at 40°C for 10 minutes and stir for 2 minutes. At the end, raise the temperature to 55°C, stir for another 3 minutes, and then cool to room temperature.

[0071] The spices are prepared by removing impurities from mint and lavender flowers, soaking them in 60° C. pure water, then crushing them, adding them into pure water for distillation, and cooling the distillate extracted after distillation to make the spices.

[0072] When adjusting the pH, the pH was controlled at 7.0.

[0073] The odor of the air mainly comes from ammonia compounds, sulfides and their organic compounds. The ability to remove ammonia, toluene and sulfide is used to test the odor removal ability of artemisinin. The insect repellent rate, that is, the effect on mosquitoes, is tested by repelling mosquitoes. Since the air contains E. coli, the disinfection effect of artemisinin is tested by killing E. coli. The control group is directly controlled by artemisinin, and the data in the following table are prepared:

[0074]

[0075] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. An artemisinin, characterized in that: Includes the following ingredients: Artemisia annua 30%, Artemisia argyi 40%, Artemisia argyi 30%.

2. The method for preparing artemisinin according to claim 1, characterized in that: The following steps are involved: S11, preparing Artemisia annua, Artemisia argyi and Artemisia argyi, and cleaning them; S12, squeezing out the juice from the Artemisia annua, Artemisia argyi and Artemisia argyi by squeezing liquid; S13, filtering the juice, while using pure water to rinse the leaf residue and stem residue intercepted by the filter, and then precipitating the filtered juice to remove fine sediment; S14, adding the juice obtained in step S13 into purified water of the same specific gravity and stirring and mixing; S15, adding 50% alcohol to precipitate fats, proteins and sugars in the plants, filtering the precipitated substances by ultrafiltration, and purifying the liquid; S16, bottling the purified raw liquid and storing it in storage.

3. The method for preparing three kinds of wormwood according to claim 2, characterized in that: When squeezing, the Artemisia leaves and Artemisia stems are separated and squeezed separately by using an squeezing machine. The Artemisia leaves are squeezed 2-3 times, and the Artemisia stems are squeezed 3-4 times.

4. The method for preparing artemisinin according to claim 1, characterized in that , including the following steps: S21, preparing Artemisia annua, Artemisia argyi and Artemisia scoparia, washing Artemisia annua, Artemisia argyi and Artemisia scoparia, and chopping Artemisia annua, Artemisia argyi and Artemisia scoparia; S22, putting the chopped Artemisia annua, Artemisia argyi and Artemisia argyi into a distiller, controlling the temperature of the distiller to be 110-116° C. for 2-4 hours; S22, condensing and collecting the steam as raw materials; S23, mixing the raw material and purified water in a proportioned manner, detecting the pH value of the raw material, and adjusting the pH value; S24, conduct bacterial culture test on the prepared raw materials, adjust the fragrance of the raw materials and then bottle them.

5. The method for preparing artemisinin according to claim 4, characterized in that: When adjusting the fragrance, add the fragrance while controlling the temperature at 30-40°C for 5-10 minutes, stir for 1-2 minutes, raise the temperature to 50-55°C, stir for 2-3 minutes, and then cool to room temperature.

6. The method for preparing artemisinin according to claim 5, characterized in that: The spices are prepared by removing impurities from mint and lavender flowers, soaking them in pure water at 50-60°C, then crushing them, adding them into pure water for distillation, and cooling the distillate extracted after distillation to make the spices.

7. The method for preparing artemisinin according to claim 6, characterized in that: When adjusting the pH value, control the pH value at 6.4-7.0.

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