Application of alkyl resorcinol to preparation of product for preventing or treating obesity related diseases

A technology of alkyl resorcinol and heptadecyl resorcinol, applied in the field of weight loss products, can solve problems such as poor effect of alkyl resorcinol, and achieve the effect of improving weight gain

Active Publication Date: 2020-01-03
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

KatsutakaOishi et al. (Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose tolerance by increasing insulin sensitivity and cholesterol excretion in male mice.[J].Journal of Nutrition,2015,145(2):199.) think that alkanes Resorcinol has a better anti-obesity effect, while Rania Agil et al. (Triticale BranAlkylresorcinols Enhance Resistance to Oxidative Stress in Mice Fed a High-Fat Diet[J]. Foods, 2016, 5(4).) Alkyl resorcinols considered less effective in fighting obesity
Although

Method used

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  • Application of alkyl resorcinol to preparation of product for preventing or treating obesity related diseases
  • Application of alkyl resorcinol to preparation of product for preventing or treating obesity related diseases
  • Application of alkyl resorcinol to preparation of product for preventing or treating obesity related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A medicine for preventing and / or treating obesity-related diseases and improving energy metabolism, which comprises the active ingredient alkylresorcinol, and the alkylresorcinol is composed of the following monomers in weight percentage:

[0051] Heptadecyl resorcinol 3%; Nonadecyl resorcinol 24.4%; Heptadecyl resorcinol 51.6%; Tricosyl resorcinol 9.4%; Pentadecyl resorcinol Resorcinol 11.6%;

[0052] The preparation method of described alkyl resorcinol comprises the steps:

[0053] S1 Soak wheat bran (Jimai 22 wheat bran provided by Sinograin Shandong Branch, variety right number: CNA20060015.X) in absolute ethanol and stir for 24 hours, then spin evaporate to remove solvent to obtain extract, wherein wheat bran and ethanol The mass volume ratio of the solution is 1:5Kg / L; the density of the extract is 0.90-0.91g / mL;

[0054] S2 Mix the extract with silica gel (200 mesh) at a volume ratio of 1:15 and put it on a column (15L column volume, 150mm in diameter) to elute...

experiment example 1

[0056] Application of alkyl resorcinol in preparation of products for preventing or treating obesity

[0057] In order to further study the role of alkyl resorcinol in preventing or treating obesity by improving energy metabolism and increasing body heat production, the drug provided in Example 1 was used, and the following test was carried out in this test example:

[0058] A total of 48 4-week-old healthy C57BL / 6 mice were randomly selected and divided into four groups on average, with 12 mice in each group. C57BL / 6 mice ingested 60% high-fat diet), high-fat diet and low-dose ARs group (C57BL / 6 mice ingested 60% high-fat diet and 0.4% ARs in the diet) and high-fat diet at the same time High-dose ARs group (C57BL / 6 mice ingested 60% high-fat diet and supplemented with 1% ARs). The average daily food intake of the mice was 150g / kg / d. During the administration period, the body weight changes of the mice during the diet induction period were detected and recorded weekly; after ...

Embodiment 3

[0065] Study on Glucose Tolerance of Alkyl Resorcinols

[0066] A total of 48 4-week-old healthy C57BL / 6 mice were randomly selected and divided into four groups on average, with 12 mice in each group. C57BL / 6 mice ingested 60% high-fat diet), high-fat diet and low-dose ARs group (C57BL / 6 mice ingested 60% high-fat diet and 0.4% ARs in the diet) and high-fat diet at the same time High-dose ARs group (C57BL / 6 mice ingested 60% high-fat diet and added 1% ARs by weight to the diet).

[0067] After 12 weeks of continuous administration, fast overnight, and after weighing, 1 g of glucose per kilogram of body weight was gavaged, and the mice were detected at 15 minutes, 30 minutes, 60 minutes, 90 minutes and 120 minutes after gavage with a blood glucose meter. blood sugar level.

[0068] Such as Figure 5-6 As shown, ARs intake significantly improved the glucose tolerance induced by high-fat diet in mice. After 12 weeks of diet induction, the blood glucose area of ​​the high-fat ...

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Abstract

The invention belongs to the technical field of weight-loss products, and particularly relates to application of alkyl resorcinol to preparation of a product for preventing or treating obesity relateddiseases. The application of the alkyl resorcinol to preparation of the product for preventing and/or treating the obesity related diseases and improving energy metabolism and heat production of a body is characterized in that the product contains the active ingredient alkyl resorcinol, the alkyl resorcinol is prepared from the following monomers in percentage by weight: 1-10% of heptadecyl resorcinol, 20-25% of nonadecyl resorcinol, 50-55% of heneicosyl resorcinol, 5-10% of tricosyl resorcinol and 5-12% of pentacosyl resorcinol. According to the application, the appropriate ratio of each constituent monomer corresponding to the prevention or treatment of the obesity by improving the energy metabolism of the body or improving the heat production of the body through the alkyl resorcinol isdefined.

Description

technical field [0001] The invention belongs to the technical field of weight loss products, and specifically relates to the application of alkyl resorcinol in the preparation of products for preventing or treating obesity-related diseases. Background technique [0002] Alkyl resorcinols (ARs) are a special class of phenolic lipids discovered in wheat, rye and other wheat for the first time by Wenkert et al., and have amphiphilic properties. ARs is a general term for a class of derivatives in which the 5-position of the 1,3 resorcinol benzene ring is substituted by an alkyl group containing an odd number of carbon atoms, and its content is 300-1500 μg / g grain. Alkyl resorcinols can be absorbed by the body, so they are often used as important biomarkers of whole grain diets. [0003] ARs alkyl chains vary in length, and some ARs alkyl chains (fatty chains) contain one to three double bonds or substituents such as ketone groups and hydroxyl groups. The biological activities ...

Claims

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Application Information

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IPC IPC(8): A61K31/05C07C37/68C07C39/08A61P3/04
CPCA61K31/05A61P3/04C07C37/68A61K2300/00C07C39/08
Inventor 王静刘洁郝一铭杨子慧孙宝国
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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