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Application of alpha-oxoglutarate to improving heat production capability of fat animals and reducing body fat content

A technology of ketoglutaric acid and heat generating capacity, which is applied in the field of animal metabolism to achieve the effect of being safe and easy to obtain, without toxic side effects, and with a small amount of addition.

Inactive Publication Date: 2018-09-18
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide α-ketoglutaric acid to improve the body heat production and brown fat heat production of obese animals, and reduce the body heat production of obese animals in view of the shortcomings of the above-mentioned existing schemes for promoting body heat production and improving energy metabolism. The application of total fat content and fat weight in different parts can improve the adverse effects of high-fat diet or obesity on animals while broadening the application range of α-ketoglutaric acid

Method used

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  • Application of alpha-oxoglutarate to improving heat production capability of fat animals and reducing body fat content
  • Application of alpha-oxoglutarate to improving heat production capability of fat animals and reducing body fat content
  • Application of alpha-oxoglutarate to improving heat production capability of fat animals and reducing body fat content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 α-ketoglutaric acid can improve the oxygen consumption and heat production capacity of mice fed with high-fat diet

[0034] 1. In order to study the effect of α-ketoglutarate (AKG) on the oxygen consumption and heat production capacity of mice fed with high-fat diet, 10-week-old female C57BL / 6 mice were used as the research object.

[0035] 2. Experimental method

[0036] (1) Animal feeding conditions: 1 animal / box, single breeding; feeding temperature and humidity: 20-26°C, 40%-70%; 12 h: 12 h day and night intermittent lighting; the conditions of the breeding room are always kept stable to ensure the test reliability of the results. Free access to food and water, feed and drinking water were provided by the Guangdong Provincial Medical Experimental Animal Center; Quarantine: Pre-feeding of purchased SPF grade C57BL / 6 J mice for 7 days. Animals were checked once a day during this period.

[0037] (2) Animal grouping and treatment: Twenty 10-week-old female...

Embodiment 2

[0045] Example 2 Adding 2% α-ketoglutarate to drinking water to reduce body fat content in mice fed a high-fat diet

[0046] 1. In order to study the effect of α-ketoglutarate on the body fat content of high-fat fed mice, 10-week-old female C57BL / 6 mice were used as the research object.

[0047] 2. Experimental method

[0048] (1) Animal feeding method: same as in Example 1.

[0049] (2) Grouping and treatment of animals: the same as in Example 1.

[0050] (3) Sampling and detection: Body composition and body imaging tests were performed at the eighth week of the experiment.

[0051] 3. The result is as follows figure 2 Shown:

[0052] (1) The results are attached figure 2 As shown in A and 2B, supplementation of drinking water with 2% α-ketoglutarate significantly reduced the total fat content of mice fed a high-fat diet compared with the high-fat group.

[0053] (2) At the 20th week of the experiment, the abdominal fat and subcutaneous fat of the mice were sampled an...

Embodiment 3

[0055] Example 3 Adding 2% α-ketoglutarate to drinking water can improve the heat production capacity of brown fat in mice fed a high-fat diet

[0056] 1. In order to study the effect of α-ketoglutarate on the heat production ability of brown fat in mice fed with high fat, the experiment took 10-week-old female C57BL / 6 mice as the research object.

[0057] 2. Experimental method

[0058] (1) Animal feeding method: same as in Example 1.

[0059] (2) Grouping and treatment of animals: the same as in Example 1.

[0060] (3) Sampling and detection: In order to further study the effect of α-ketoglutarate on the expression of thermogenic genes in brown fat of mice, we collected brown adipose tissue of mice and detected the related thermogenic genes in brown fat of mice protein expression and mRNA expression.

[0061] 3. The result is as follows image 3 Shown:

[0062] (1) if image 3 As shown in A and 3B, compared with the high-fat group, drinking water supplemented with 2% α...

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Abstract

The invention discloses application of alpha-oxoglutarate to improving the heat production capability of fat animals and reducing the body fat content. The invention provides new application of alpha-oxoglutarate, alpha-oxoglutarate can obviously improve whole heat production of high fat diet animal bodies and heat production of brown fat, can prominently improve expression of brown fat heat producing marker genes UCP1, PRDM16, PGC1alpha, Cidea and Elovl3, and meanwhile, can reduce the overall body fat content of the high fat diet animal bodies and the fat weight of different parts. In addition, alpha-oxoglutarate does not contain any substance harmful to animals or human body, the adding amount is less, and alpha-oxoglutarate can be directly added into animal drinking water, fodder, foodor drugs, has the advantages of safety, effectiveness and no toxic and side effects, has the wide application prospect at the aspect of improving heat production of the high fat diet animals and reducing the body fat content, and explores a new means for treating obesity and related diseases.

Description

technical field [0001] The invention belongs to the technical field of animal metabolism, and relates to the application of α-ketoglutarate in improving the body heat production capacity of obese animals and reducing the body fat content of obese animals, in particular to the application of α-ketoglutarate in improving the body heat production of obese animals and the heat production capacity of brown fat, as well as the application in reducing the total body fat content and fat weight of different parts of obese animals. Background technique [0002] For most warm-blooded animals, maintaining a constant body temperature in various complex environments requires an efficient temperature regulation system. The constant body temperature comes from the balance of heat production and heat dissipation. There are four main sources of heat in animals: basal metabolism, physical activity, thermogenesis caused by cold stimulation (including shivering thermogenesis and non-shivering t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61P3/04A61P43/00A23L33/00A23L2/38A23K20/105
CPCA61P3/04A61P43/00A23K20/105A23L2/38A23L33/00A61K31/194A23V2002/00A23V2200/3324
Inventor 王松波江青艳束刚张枫琳朱晓彤王丽娜高萍
Owner SOUTH CHINA AGRI UNIV
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