32results about How to "Does not cause toxic side effects" patented technology

The invention discloses application of alpha-oxoglutarate to improving the heat production capability of fat animals and reducing the body fat content. The invention provides new application of alpha-oxoglutarate, alpha-oxoglutarate can obviously improve whole heat production of high fat diet animal bodies and heat production of brown fat, can prominently improve expression of brown fat heat producing marker genes UCP1, PRDM16, PGC1alpha, Cidea and Elovl3, and meanwhile, can reduce the overall body fat content of the high fat diet animal bodies and the fat weight of different parts. In addition, alpha-oxoglutarate does not contain any substance harmful to animals or human body, the adding amount is less, and alpha-oxoglutarate can be directly added into animal drinking water, fodder, foodor drugs, has the advantages of safety, effectiveness and no toxic and side effects, has the wide application prospect at the aspect of improving heat production of the high fat diet animals and reducing the body fat content, and explores a new means for treating obesity and related diseases.

The invention discloses a method for improving the quality of radix scutellariae with sodium hyposulfite and relates to the technical field of radix scutellariae. The method comprises the steps of radix scutellariae fresh root extracting-washing-drying in shade for 1-2 days under the temperature of 20-25 DEG C-active oxygen carrier spraying-standing for 3-10 days under the temperature of 20-25 DEG C-drying. An active oxygen carrier is the sodium hyposulfite. The concentration of the sodium hyposulfite is 0.4 mumol / L-40 mmol / L. The processing time cycle is 3-15 days. Temperature is 10-35 DEG C. According to the method, traditional Chinese medicinal materials are planted in the zone most suitable for plants to grow in or in a main producing zone, various measures can be taken to improve yield, according to the essence of radix scutellariae quality forming, after medicine collecting, secondary metabolism of fresh medicine materials is subjected to human intervention, so that medicine material quality is greatly improved, and accordingly high quality and high yield are achieved. The secondary metabolism level of radix scutellariae is improved to the maximum degree, and the quality of all produced medicine materials reaches or exceeds the quality of famous-region drugs.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine foot soaping liquid for treating diabetes, and solves the problems that the traditional method for treating diabetes by orally taking drugs and injecting insulin has serious toxic side effect and bad curative effect and easily causes complicating disease and drug resistance. The liquid is composed of 14 drugs including leech, muskiness, chicken-bone herb, pericarpium zanthoxyli, red paeonia, mugwort leaf, radix aconiti, Guilu Erxian Jiao, prepared rhizome of rehmannia, Dioscorea opposita, cortex moutan, ginseng, polygonatum and the like. The drugs are soaked and then concentrated under normal pressure and concentrated under vacuum by a traditional Chinese medicine vacuum extracting machine set for extracting liquid medicines, and then the liquid medicine is made into a drug for external use preferably by a plenty of Chinese herbal medicines and by a special modern processing method in accordance with theory of traditional Chinese medicine. The drug is used in a foot soaking manner and a footherapy manner for treatment, and the drug has the functions, for human body, of soothing the liver and controlling breathing, promoting the production of body fluid to quench thirst, recovering glucose metabolism, balancing blood sugar, decreasing blood fat, promoting insulin secretion and keeping the blood sugar stable for a long time, and can enhance the immunity of the organism and avoid all defects of traditional oral drugs.

The invention discloses application of oleic acid in animal mammary gland development promotion and provides new application of the oleic acid. Cell experiments and animal experiments prove that the oleic acid can effectively promote the proliferation of pig primary mammary gland epithelial cells and mouse mammary gland epithelial cells HC11 and can increase the number of in-vivo mouse mammary gland duct branches and TEB to promote animal mammary gland development. The application has the advantages that the oleic acid is rich in source, free of substances harmful to animals and human being, safe and easy to obtain; in addition, the adding amount of the oleic acid in the application is low, and the oleic acid serving as the nutrition regulation substance can be directly added into animal feed, food or drugs and is safe, effective, free of toxic and side effects and promising in popularization and application prospect in the animal mammary gland development promotion.

The invention discloses a method for improving the quality of Scutellaria baicalensis by using sodium dithionite, which relates to the technical field of Scutellaria baicalensis. The preparation method is as follows: fresh roots of scutellaria baicalensis→cleaning→drying in the shade at 20-25°C for 1-2 days→spraying active oxygen Carrier → placed at 20-25°C for 3-10 days → dry; the active oxygen carrier is sodium dithionite, the concentration of sodium dithionite is 0.4μmol / L-40mmol / L; the treatment time period is 3-15 day; the temperature is 10-35°C; the present invention plants Chinese herbal medicines in the most suitable plant growth area or in the main production area, and various measures can be taken to increase the yield; according to the nature of the quality of Scutellaria baicalensis, artificially Intervene in the secondary metabolism of fresh medicinal materials, greatly improve the quality of medicinal materials, so as to achieve a double harvest of quality and yield. The invention maximizes the level of secondary metabolism of Scutellaria baicalensis, so that all the medicinal materials produced can reach or exceed the quality of authentic medicinal materials.

The invention discloses an application of alpha-ketoglutaric acid to improvement of animal reproduction function deficit caused by high fat diet, and provides a novel application of the alpha-ketoglutaric acid. Abnormity of animal estrus cycle, ovarian morphology and functions and sex hormone secretion caused by high fat diet can be remarkably improved by the alpha-ketoglutaric acid, animal reproduction function deficit caused by high fat diet is further improved, and particularly, estrus cycle disorder, corpus luteum number depletion, theca cell thickness increase, follicle-stimulating hormone content reduction and luteinizing hormone content rise caused by high fat diet are improved by the alpha-ketoglutaric acid, so that animal reproduction function deficit caused by high fat diet can be remarkably improved. Moreover, the alpha-ketoglutaric acid is free from substances harmful to animals or human bodies, adding quantity is small, and the alpha-ketoglutaric acid can be directly added into animal drinking water, feed, food or drugs, has the advantages of safety, effectiveness, no toxic and side effects and the like and has a good popularization and application prospect in improvement of animal reproduction function deficit caused by high fat diet.

The invention provides an incense fumigating agent for coryza which is prepared from the essential oil components of six aromatic plants, which comprises tree plant oil, lavandula angustifolia oil, thyme oil, lemon oil, piper nigrum peppermint oil, and sweet basil oil.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine foot soaping liquid for treating diabetes, and solves the problems that the traditional method for treating diabetes by orally taking drugs and injecting insulin has serious toxic side effect and bad curative effect and easily causes complicating disease and drug resistance. The liquid is composed of 14 drugs including leech, muskiness, chicken-bone herb, pericarpium zanthoxyli, red paeonia, mugwort leaf, radix aconiti, Guilu Erxian Jiao, prepared rhizome of rehmannia, Dioscoreaopposita, cortex moutan, ginseng, polygonatum and the like. The drugs are soaked and then concentrated under normal pressure and concentrated under vacuum by a traditional Chinese medicine vacuum extracting machine set for extracting liquid medicines, and then the liquid medicine is made into a drug for external use preferably by a plenty of Chinese herbal medicines and by a special modern processing method in accordance with theory of traditional Chinese medicine. The drug is used in a foot soaking manner and a footherapy manner for treatment, and the drug has the functions, for human body, of soothing the liver and controlling breathing, promoting the production of body fluid to quench thirst, recovering glucose metabolism, balancing blood sugar, decreasing blood fat, promoting insulin secretion and keeping the blood sugar stable for a long time, and can enhance the immunity of the organism and avoid all defects of traditional oral drugs.

The invention discloses a method for using hydrogen peroxide to improve the quality of windproof medicinal materials, and relates to the technical field of windproof medicinal materials. Place at 20-25°C for 3-10 days → dry; the active oxygen is hydrogen peroxide, and the concentration of hydrogen peroxide is 0.2μmol / L-50mmol / L, the treatment time period is 3-15 days; the temperature is 10-35°C. During the cultivation process of Fangfeng, any high-yield measures can be adopted to tap the high-yield potential. Through the treatment of fresh medicinal materials, the present invention maximizes the level of secondary metabolism and the quality of medicinal materials, so that the quality of cultivated Fangfeng medicinal materials can reach or exceed the quality of wild authentic medicinal materials. . Both output and quality are realized; the invention is easy to operate and easy to popularize.

The invention discloses Prussian blue analog nanoparticles. The nanoparticles are formed by using Prussian blue analog nanoparticles as the core and coating organic high-polymer surface protectants polyvinylpyrrolidone / chitosan and hyaluronic acid on the nanoparticle surface. The preparation method of the Prussian blue analog nanoparticles comprises the following steps: S1. preparing a mixed solution containing a zinc salt, ferrous sulfate, an iron salt and an organic high-polymer surface protectant; S2. stirring at room temperature for 30 minutes to 2 hours, putting the solution into a dialysis bag filled with distilled water, and dialyzing for two days; and S3. taking out the solid matter, and collecting the solid product by freeze-drying. The Prussian blue analog nanoparticles are used in cancer targeted therapy. The Zn-FePB NPH drug is very safe. The copper element in cancer cells can be replaced to achieve the goal of starving the cancer cells. PVP (or chitosan) doping is carried out on the basis of the high targeting action of the hyaluronic acid to better regulate the size of the nanoparticles.

The invention discloses a method for improving the quality of a wind-proof medicinal material by using sodium dithionite, which relates to the technical field of wind-proof medicinal materials. The preparation method is as follows: fresh root of a wind-proof root→cleaning→drying in the shade at 20-25°C for 1-2 days→spraying activity Oxygen carrier → place at 20-25°C for 3-10 days → dry; the active oxygen carrier is sodium dithionite, and the concentration of sodium dithionite is 0.1μmol / L-50mmol / L, and the treatment time period is 3 ~15 days; temperature 10‑35°C. During the cultivation process of Fangfeng, any high-yield measures can be adopted to tap the high-yield potential. Through the treatment of fresh medicinal materials, the present invention maximizes the level of secondary metabolism and the quality of medicinal materials, so that the quality of cultivated Fangfeng medicinal materials can reach or exceed the quality of wild authentic medicinal materials. . Both output and quality are realized; the invention is easy to operate and easy to popularize.

The invention discloses a compound composition of citral and carvacrol and its application. The combination of citral and carvacrol can inhibit the growth of Clostridium spp, can effectively control the number of Clostridium spp. in the intestinal tract of poultry, and can not only reduce the mortality of broiler chickens with necrotizing enteritis, the score of necrotizing enteritis lesions and the production of caecal contents. The number of Clostridium perfringens can also promote the growth performance of broilers with necrotizing enteritis, increase the average daily feed intake and final body weight, and promote the growth of broilers with necrotizing enteritis. It can be used to prevent necrotizing enteritis caused by Clostridium perfringens infection Enteritis and has a good application prospect.

The invention discloses a feed additive for necrotizing enteritis of livestock and poultry, provides new uses of muscadine pomace, cardamom, woodsy, bagasse, Sophora flavescens and inulin, and also provides a livestock and poultry The preparation method of feed and feed additive; it is confirmed by animal feeding experiments that the feed additive of the present invention can not only reduce the mortality of broiler chickens with necrotizing enteritis and intestinal lesions of necrotizing enteritis, effectively improve the necrotizing enteritis of chickens, but also improve the average daily feed intake It can reduce the dextran content in serum of necrotizing enteritis broilers, increase the content of IGF-I and EGF in serum, and promote the development of animal intestines, thereby promoting the growth performance of animals. It has a good prospect of promotion and application in tract development.

The invention relates to the field of biological medicines, and particularly discloses application of alanine serving as a vaccine adjuvant. According to the application of alanine, the alanine is added or not added into a vaccine to discover that the death rate an experimental animal is significantly reduced after the alanine is added in comparison with that without the alanine, which shows that the alanine can be used for improving the immune effect of the vaccine and can be used as an immunologic adjuvant of the vaccine.

The invention discloses a methylprednisolone delivery material based on epsilon-polylysine, a preparation method of the methylprednisolone delivery material, and a kit. The methylprednisolone deliverymaterial can prolong the residence time of methylprednisolone in an articular cavity and prolong the half-life period of methylprednisolone, has cartilage permeability and cell membrane permeability,can permeate into cartilage tissue and stem cells and cartilage cells in the cartilage tissue in the form of an integral material. The methylprednisolone delivery material degrades under the action of intracellular enzymes to release methylprednisolone, so that the bioavailability of the methylprednisolone is improved. The methylprednisolone delivery material provided by the invention has excellent tissue and cell compatibility, does not cause toxic or side effects, and has good biodegradability, and degradation products do not have toxicity. Besides, the material is simple to prepare, the using process is very simple, and articular cavity injection administration can be directly performed.