Application of multienzyme compound to prevention and treatment of fungus infection

A multi-enzyme complex and fungal infection technology, which is applied in the field of multi-enzyme complexes, can solve problems such as large side effects and treatment failure, and achieve the effects of promoting penetration, reducing toxic side effects, and reducing the chance of drug resistance

Inactive Publication Date: 2011-11-16
上海杜伊特医疗器械有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The side effects of these drugs
At the same time, due to long-term use, fungi that are resistant to these drugs have been produced, resulting in treatment failure
[0003] At present, there is no green, safe and non-toxic drug on the market that is based on the prevention and treatment of fungal infections in a true sense

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0025] Implementation 1 2 3 4 5 6

[0026] Pharmaceutical excipients 70 97 96 85 90 49.5

[0027] (gram)

[0028] chitinase complex 10 1 1 5 3 10

[0029] compound (g)

[0030] Dextranase Complex 10 1 1 5 3 20

[0031] compound (g)

[0032] Cellulase Complex 10 1 1 5 3 20

[0033] compound (g)

[0034] Antifungal drugs 0 0 1 0 1 0.5

[0035] (gram)

[0036] The concrete preparation method of above-mentioned embodiment of the present invention is:

[0037] Take an appropriate amount of sterile water, dissolve all the various enzyme complexes that need to be added in the sterile water for the first time, filter and sterilize with a filter membrane, and obtain a sterilized enzyme solution. Vacuum freeze-drying, adding pre-prepared aseptic pharmaceutical auxiliary materials, and preparing into a suitable preparation form.

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PUM

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Abstract

The invention provides a multienzyme compound capable of preventing and treating fungus infection. The multienzyme compound of the invention can be used in daily prevention of fungus infection, and can kill fungi selectively without generation of toxic or side effects, or drug resistance. The multienzyme compound of the invention can treat fungus infection individually. Because the multienzyme compound can digest fungus cell walls, when cooperated with other antifungal medicaments to treat fungus infection, the multienzyme compound of the invention can promote penetration of other medicaments, enhance treatment effects of other medicaments effectively, reduce dosage and application amount, lower toxic and side effects, and reduce generation probability of drug resistance. In addition, the multienzyme compound of the invention can be selectively added with antifungal medicaments to improve treatment effects.

Description

technical field [0001] The invention relates to a multi-enzyme complex, in particular to the application of the multi-enzyme complex in preventing and treating fungal infections. Background technique [0002] Fungal infection can cause beriberi, vaginitis, head moss, hand moss, stock moss, tinea corporis and other common external infection diseases. At the same time, deep fungal infection can invade the lungs and other parts, seriously threatening life safety. At present, there are few drugs that can effectively treat fungal infections, mainly griseofulvin, nystatin, amphotericin B and other antibiotics and metronidazole, miconazole and its derivatives, clotrimazole, ketoconazole, fluoride, etc. Conazole and itraconazole, terbinafine hydrochloride and other chemical drugs. These medicines have side effects. At the same time, due to long-term use, fungi that are resistant to these drugs have been produced, resulting in treatment failure. [0003] At present, there is no g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/43A61K38/54A61K9/00A61P31/10
Inventor 邢建慧
Owner 上海杜伊特医疗器械有限公司
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