Medicament for treating AIDS and its preparing method

A technology of AIDS and drugs, which is applied in the field of AIDS drugs and its preparation, can solve the problems of inability to completely remove viruses in the body, lack of complete and in-depth research, and restrictions on drug application, so as to improve human immunity, improve the degree of comprehensive utilization, obvious curative effect

Inactive Publication Date: 2007-08-08
张石泉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the treatment of AIDS, there is still no curable drug in the world. Most of the drugs currently used for AIDS treatment are chemical drugs. Although they can relieve symptoms and prolong the course of the disease, there are still many problems: the virus in the body cannot be completely removed, and the drug rebounds. Drug resistance is easy to occur, side effects are large and treatment costs are high, which greatly restricts the application of these drugs, so traditional drugs with low toxicity, effectiveness and low price, especially traditional Chinese medicine, have attracted much attention at home and abroad.
However, there is no complete and in-depth study on its antiviral effect and its pharmacological efficacy, and there is a lack of conclusive experimental data.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A drug for treating AIDS, the active ingredient of which is sulfonic acid fucoside polypeptide polymer, which is the effective part of the single Chinese medicine kelp, and is a kind of Proteoglycans containing sulfate ester groups, its main physical and chemical characteristics are: easily soluble in water, solubility ≥ 30%, white or yellow polycrystalline powder, with special fragrance; SO 4 2- The content is 20±5%, the fucose content is 20±5%, and the protein content is 10-18%.

[0025] The preparation method of the medicine, the production and extraction process of the sulfonic acid fucoside polypeptide polymer include the following steps: 100kg of seaweed is soaked, washed, crushed, added with 800kg of water, and extracted three times at 90-100°C for 3.5 hours. The supernatant was concentrated under reduced pressure to 25 L, precipitated under 30% ethanol, then the supernatant was evaporated to 10 L under reduced pressure, added to 85 L of 95% ethanol, and filtere...

Embodiment 2

[0027] A kind of medicine for treating AIDS, the mechanism of its sulfonic acid fucoside polypeptide polymer anti-HIV effect is as follows:

[0028] The first is to inactivate HIV-1 virions; the second is to block free HIV-1 virus from adsorbing cells; the third is to inhibit the activity of HIV-1 reverse transcriptase; the fourth is to inhibit the replication of HIV-1 in infected cells. Its features are as follows: first, it can promote the growth of lymphocytes; second, it can inhibit the acute and chronic infection of H1V-1; third, it can inhibit HIV-1 replication at multiple sites;

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Abstract

Disclosed is a medicament for treating AIDS, wherein the active constituents include Fucoidan-Glycocalyx polymeric compound, which is a protein polysaccharide containing sulfate groups extracted from Chinese herbal sea apron. The preparing process consists of steps of choosing materials, soaking and cleaning, disintegrating, water extracting, low concentration alcohol depositing, high concentration depositing, purifying to obtain the end product.

Description

1. Technical field [0001] The invention relates to a drug for treating AIDS and a preparation method thereof, belonging to the technical field of drugs for treating AIDS. 2. Background technology [0002] AIDS (AIDS) caused by HIV (HIV) is a highly contagious and extremely harmful infectious disease. At present, according to statistics, there are 40 million HIV-infected people in the world, 15,000 new HIV-infected people in the world every day, and 8,500 people die from AIDS every day. In my country, AIDS infection has expanded from special populations to general populations. According to statistics, the number of HIV-infected people in my country has reached 1 million. If not properly controlled, by 2010 it could reach 10 million people. For the treatment of AIDS, there is still no curable drug in the world. Most of the drugs currently used for AIDS treatment are chemical drugs. Although they can relieve symptoms and prolong the course of the disease, there are still man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61P31/18
Inventor 张石泉丛渝刘德生
Owner 张石泉
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