Decoquinate liposome and preparation method and application thereof

A technology of decoquinate and liposomes, which is applied in the field of medicine, can solve the problems of poor inhibition of malaria parasites, etc., and achieve simple and feasible preparation methods, poor repeatability, and good anti-malarial effects

Active Publication Date: 2019-12-20
BLUE ELEGANT BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PCT / CN2015 / 096689), but the inhibitory effect on the Plasmodium entering the red inner stage is not good enough

Method used

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  • Decoquinate liposome and preparation method and application thereof
  • Decoquinate liposome and preparation method and application thereof
  • Decoquinate liposome and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The present embodiment provides a kind of decoquinate liposome, and its preparation method comprises the following steps:

[0065] (1) Accurately weigh 20mg decoquinate, 80mg soybean lecithin, 15mL absolute ethanol and 285mL water;

[0066] (2) Place the above-mentioned decoquinate and soybean lecithin in absolute ethanol, heat in a boiling water bath for 10 minutes to dissolve, and use it as the organic phase;

[0067] (3) Magnetically stir the water phase at a stirring speed of 500rpm. Slowly inject the organic phase obtained in step (2) into the water phase with a pipette. The volume ratio of the organic phase to the water phase is 1:19. Continue stirring for 2 min after injecting into the aqueous phase to obtain the decoquinate liposomes.

Embodiment 2

[0069] The present embodiment provides a kind of decoquinate liposome, and its preparation method comprises the following steps:

[0070] (1) Accurately weigh 20mg decoquinate, 40mg soybean lecithin, 10mg cholesterol, 30mL absolute ethanol and 270mL water;

[0071] (2) Place the above-mentioned decoquinate, soybean lecithin and cholesterol in absolute ethanol, heat in a boiling water bath for 10 minutes to dissolve, and use it as the organic phase;

[0072] (3) Water is used as the water phase, magnetically agitated the water phase, and the stirring speed is 1000rpm, and the organic phase obtained in step (2) is slowly injected into the water phase with a pipette, and the volume ratio of the organic phase to the water phase is 1: 9. Continue stirring for 5 min after all the organic phase is injected into the water phase to obtain the decoquinate liposomes.

Embodiment 3

[0074] The present embodiment provides a kind of decoquinate liposome, and its preparation method comprises the following steps:

[0075] (1) Accurately weigh 40mg decoquinate, 80mg soybean lecithin, 130mg polyethylene glycol 15-hydroxystearate, 30mL absolute ethanol and 270mL water;

[0076] (2) Place the above-mentioned decoquinate and soybean lecithin in absolute ethanol, heat in a boiling water bath for 10 minutes to dissolve, and use it as the organic phase;

[0077] (3) Water is used as the water phase. Add polyethylene glycol 15-hydroxystearate into the water, magnetically stir the water phase at a stirring speed of 200 rpm, and slowly inject the organic phase obtained in step (2) into the water phase with a pipette , the volume ratio of the organic phase to the aqueous phase is 1:9, and after all the organic phases are injected into the aqueous phase, continue to stir for 5 minutes to obtain the decoquinate liposomes.

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Abstract

The invention relates to a decoquinate liposome and a preparation method and application thereof. The preparation raw materials of the decoquinate liposome comprise the following components in parts by weight of 1 part of decoquinate and 2-20 parts of lecithin. The liposome is good in stability, shows favorable malaria resisting effects in and out of animal bodies, can be used for quickly relieving symptoms of malaria particularly subtertian malaria, and is high in safety. The preparation method is simple and feasible, and the decoquinate liposome has mass production potential.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a decoquinate liposome and a preparation method and application thereof, in particular to a decoquinate liposome and a preparation method and application thereof. Background technique [0002] Malaria is a disease caused by the introduction of Plasmodium parasites through the bite of Anopheles mosquitoes. Plasmodium that infects humans includes Plasmodium vivax, P. falciparum, P. malariae, and P. ovale. Plasmodium knowlesi can infect monkeys and monkeys, and the most common Plasmodium infections are Plasmodium falciparum and Plasmodium vivax. The clinical manifestations of malaria are mostly high fever, headache, sweating, etc.; severe cases may have weakness, vomiting, etc. Falciparum malaria generally has a rapid onset and severe condition, which can lead to severe malaria, cerebral malaria, anemia and multiple organ dysfunction, etc., and the mortality rate is also the highest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/47A61K9/19A61P33/06
CPCA61K9/127A61K9/1277A61K31/47A61K9/19A61K9/0019A61P33/06Y02A50/30A61K47/24
Inventor 曾素梅王洪星宁晓辉范银洲赵思婷秦莉陈小平
Owner BLUE ELEGANT BIOTECH CO LTD
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