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Antibacterial varicosity polytetrafluoroethylene face implant material and preparation technology thereof

A technology of polytetrafluoroethylene and implant materials, which is applied in the direction of prosthesis, coating, medical science, etc., to achieve the effect of simple and efficient process, good bacteriostatic effect and good biocompatibility

Inactive Publication Date: 2020-02-11
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the problems that the expanded polytetrafluoroethylene facial implants provided by the current prior art have poor antibacterial properties, difficult surface modification of materials and lack of reactive functional groups, the present invention provides an expanded polytetrafluoroethylene with antibacterial properties The facial implant material and its preparation process use medical-grade expanded polytetrafluoroethylene as the base material, and after activation pretreatment generates active sites on the surface of the base material, graft acrylic acid, and then through the combination of acrylic acid carboxyl functional group and polymer antibacterial agent One or more of chitosan, ε-polylysine or polyethyleneimine grafted with amino functional groups as antibacterial functional layer

Method used

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  • Antibacterial varicosity polytetrafluoroethylene face implant material and preparation technology thereof
  • Antibacterial varicosity polytetrafluoroethylene face implant material and preparation technology thereof
  • Antibacterial varicosity polytetrafluoroethylene face implant material and preparation technology thereof

Examples

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specific Embodiment approach

[0031]In this example, atmospheric pressure plasma sputtering is used to activate the grafted acrylic acid on the surface of the expanded polytetrafluoroethylene material, the carboxyl functional group is introduced through the acrylic acid, and then the polymer antibacterial agent chitosan is grafted through the reaction of the carboxyl group and the amino group to endow the material with antibacterial properties , the specific implementation is as follows:

[0032] (1) Cut the medical-grade expanded polytetrafluoroethylene material with an average pore size of 30 μm and a porosity of 50% into a sample with a size of 10×15×2mm, and uniformly coat the surface with a volume fraction of 4% and contain 5mmol / The acrylic acid solution of L ferrous sulfate inhibitor;

[0033] (2) The expanded polytetrafluoroethylene sample coated with acrylic acid solution in step (1) was subjected to atmospheric pressure plasma surface treatment for 4 minutes under the conditions of discharge pow...

Embodiment 2

[0037] In this example, atmospheric pressure plasma sputtering is used to activate the grafted acrylic acid on the surface of the expanded polytetrafluoroethylene material, the carboxyl functional group is introduced through the acrylic acid, and then the polymer antibacterial agent chitosan is grafted through the reaction of the carboxyl group and the amino group to endow the material with antibacterial properties , the specific implementation is as follows:

[0038] (1) Cut the medical-grade expanded polytetrafluoroethylene material with an average pore size of 30 μm and a porosity of 50% into a sample with a size of 10×15×2mm, and uniformly coat the surface with a volume fraction of 6% and contain 10mmol / The acrylic acid solution of L ferrous sulfate inhibitor;

[0039] (2) The expanded polytetrafluoroethylene sample coated with acrylic acid solution in step (1) was subjected to atmospheric pressure plasma surface treatment for 6 minutes under the conditions of discharge p...

Embodiment 3

[0043] In this example, atmospheric pressure plasma sputtering is used to activate the grafted acrylic acid on the surface of the expanded polytetrafluoroethylene material, the carboxyl functional group is introduced through the acrylic acid, and then the polymer antibacterial agent chitosan is grafted through the reaction of the carboxyl group and the amino group to endow the material with antibacterial properties , the specific implementation is as follows:

[0044] (1) Cut the medical-grade expanded polytetrafluoroethylene material with an average pore size of 30 μm and a porosity of 50% into a sample with a size of 10×15×2 mm, and uniformly coat the surface with a volume fraction of 8% and contain 15mmol / The acrylic acid solution of L ferrous sulfate inhibitor;

[0045] (2) The expanded polytetrafluoroethylene sample coated with acrylic acid solution in step (1) was subjected to atmospheric pressure plasma surface treatment for 8 minutes under the conditions of discharge ...

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Abstract

The invention discloses an antibacterial varicosity polytetrafluoroethylene face implant material and a preparation technology thereof. A base layer of the material consists of medical varicosity polytetrafluoroethylene, and an antibacterial function is prepared through the steps of performing surface modification on the base layer material and performing grafting with a macromolecule antibacterial agent. A specific preparation technology lies in that active site grafted acrylic is produced on the surface of the base layer material through activation pretreatment, then through a reaction of carboxyl functional groups of acrylic and with amino, a macromolecule type antibacterial agent is grafted, and antibacterial properties are given to the material. The antibacterial varicosity polytetrafluoroethylene face implant material disclosed by the invention is simple in technology and efficient, the prepared varicosity polytetrafluoroethylene face implant material has the characteristics of being good in bacteriostasis effects, safe and free from toxic and side effects, and can be widely applied to a face plastic surgery operation.

Description

technical field [0001] The invention relates to the field of implant materials, in particular to an antibacterial expanded polytetrafluoroethylene facial implant material and a preparation process thereof. Background technique [0002] With the improvement of living standards and the advancement of science and technology, people pay more and more attention to their own appearance. Plastic surgery such as rhinoplasty, lip augmentation, and wrinkle removal to repair facial defects is gradually accepted by people. An ideal implant material should have good biocompatibility to ensure that there will be no serious complications such as immune rejection, inflammation, etc. after surgery; To achieve safe and effective, beautiful and smooth, natural touch surgical effect. Silicone rubber has become the most commonly used implant material in plastic surgery such as rhinoplasty and breast augmentation due to its good biocompatibility, easy plasticity, and non-absorption by the body i...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/34A61L27/50A61L27/56
CPCA61L27/16A61L27/34A61L27/50A61L27/56A61L2400/18C08L27/18C08L5/08C08L79/02C08L77/04
Inventor 张海军张淑欣张宏伟袁坤山卢沙王如蒙鲁手涛尹玉霞段翠海侯文博
Owner SHANDONG BRANDEN MEDICAL DEVICE
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