Novel vortex magnetic-domain iron-based nano magnetic hyperthermia medium and application of medium in tumor magnetic hyperthermia

A nano-magnetic, iron-based technology, applied in the field of biomedical applications of nano-materials, can solve the problems of inability to meet tumor hyperthermia, reduce thermal conversion efficiency, and small thermal conversion efficiency, and achieve good biocompatibility and high magneto-caloric performance. , good biocompatibility

Inactive Publication Date: 2014-06-18
NORTHWEST UNIV
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Problems solved by technology

However, due to its small size (usually less than 10nm) and low magnetization limitations, the thermal conversion efficiency within the allowable alternating magnetic field range (SAR is usually around 300 W/g) cannot meet the requirements of tumor thermal treatment needs
However, although the micro-nano crystals with large size have high magnetic saturation intensity and large hysteresis area, due to the stron

Method used

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  • Novel vortex magnetic-domain iron-based nano magnetic hyperthermia medium and application of medium in tumor magnetic hyperthermia
  • Novel vortex magnetic-domain iron-based nano magnetic hyperthermia medium and application of medium in tumor magnetic hyperthermia
  • Novel vortex magnetic-domain iron-based nano magnetic hyperthermia medium and application of medium in tumor magnetic hyperthermia

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Experimental program
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Embodiment 1

[0044] 70nm Fe outer diameter 3 o 4 Preparation of nanorings:

[0045] (1) First synthesize α-Fe with an outer diameter of 70nm 2 o 3 Nanorings: synthesized by hydrothermal method. 0.8mL FeCl 3 (0.5M) aqueous solution, 0.7mL NH 4 h 2 PO 4 (0.02M) aqueous solution and 38.5mL deionized water were mixed in a 50mL reactor, stirred evenly, and reacted at 220°C for 48 hours. After the reaction, wait for the temperature to drop to room temperature naturally, wash 3 times with alcohol and water in a volume ratio of 1:1, and dry to obtain a red solid powder.

[0046] (2) Reduction of α-Fe 2 o 3 into Fe 3 o 4 Nanoring: weighing a certain mass of α-Fe 2 o 3 The nanoring is placed in a horizontal quartz tube furnace, and 5% H is fed at a flow rate of 200 sccm 2 / 95% Ar, reduced at 375°C for 2 hours to obtain a black powder solid.

[0047] figure 1 c shows the XRD schematic diagram of the black powder solid obtained in Example 1 of the present invention. The phase of the ...

Embodiment 2

[0060] Carry out magneto-caloric tests on commercial feridex widely used in clinical practice, mainly to compare the vortex magnetic domain Fe provided by the invention 3 o 4 Magnetocaloric effect of nanorings.

[0061] Formulated Commercial Feridex Fe 3 o 4 The mass concentrations were 230ug / mL, 110ug / mL and 80ug / mL respectively, and they were respectively placed in an alternating magnetic field, and the magnetic field parameters were set as: field strength H=37kA / m, f=400kHz, and an in vitro heating experiment was carried out, and the results See Figure 7 . Depend on Figure 7 It can be seen that as the concentration increases, the heating rate increases. with Fe 3 o 4 Compared with the nano ring, the initial temperature of the test is the same, but after the magneto-caloric test, when the concentration of this sample is 230ug / mL Fe, it still does not reach 42°C. Fe at concentrations of 230ug / mL Fe, 110ug / mL Fe, 80ug / mL Fe 3 o 4 The temperature of the nanorings i...

Embodiment 3

[0065] The invention provides a new type of vortex magnetic domain iron-based nano-magnetic hyperthermia medium. Its main properties are to have vortex magnetic domains caused by special morphology, high hysteresis loss, high saturation magnetization value and stable formation. magnetic sol. The core of the vortex magnetic domain iron-based nanoparticles satisfying the above conditions except the Fe in the above-mentioned embodiment case 1 3 o 4 nanorings, we also synthesized Fe 3 o 4 nanosheets, such as Figure 9 As shown, the diameter of the nanosheet is about 200 nanometers, and the thickness is 18 nanometers, which meets the conditions for forming a stable vortex magnetic domain, and the shape and size are relatively uniform.

[0066] We also synthesized MFe 2 o 4 (M=Co, Mn, Ni) nanorings and high-content Fe nanorings, the specific experimental steps are as follows:

[0067] (1) Synthesis of α-Fe 2 o 3 Nanoring or nanosheet (reference implementation case 1):

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Abstract

The invention discloses a novel high-performance vortex magnetic-domain iron-based nano magnetic hyperthermia medium and application of the medium in tumor magnetic hyperthermia. The unique vortex magnetic-domain iron-based nano magnetic hyperthermia medium comprises a core with vortex magnetic-domain iron-based nano particles, and the core is coated by an organic polymer with good biocompatibility or an inorganic material to form magnetic sol. The vortex magnetic-domain iron-based nano magnetic hyperthermia medium provided by the invention has a vortex magnetic state, high magnetic saturation intensity, good dispersion stability, high hysteresis heat loss, high heat production efficiency (specific absorption rate), for example the specific absorption rate of the vortex magnetic-domain Fe3O4 nano ring is 2000 watts/gram Fe-3000 watts/gram Fe, which is higher than magnetic heat production of Feridex in commercial use by one order of magnitude, so that cancer cells can be effectively killed. Moreover, the novel high-performance vortex magnetic-domain iron-based nano magnetic hyperthermia medium further has good biocompatibility, is safe and nontoxic and has wide application prospect in biomedicine.

Description

technical field [0001] The present invention relates to a new type of magnetic hyperthermia medium, specifically, it relates to the application of a ferromagnetic or ferrimagnet-based nanoparticle with vortex magnetic domains as a high-performance magnetic hyperthermia medium in tumor hyperthermia, belonging to nano materials for biomedical applications. Background technique [0002] In recent years, with the development of science and technology, the application of magnetic nanomaterials in biomedicine has become widespread. Among them, in the process of using magnetic nanomaterials for cancer treatment, magnetic hyperthermia has become an important auxiliary means of cancer treatment and It is so effective that it is considered to be the fifth major therapy after surgery, radiotherapy, chemotherapy and immunotherapy. Magnetic hyperthermia is to conformally distribute the magnetic medium in the treatment target area by means of implantation or intervention. Under the actio...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61N2/04A61F7/00A61P35/00
Inventor 樊海明刘晓丽任兆玉白晋涛
Owner NORTHWEST UNIV
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