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Injection type bone filling material and preparation method and using method thereof

A filling material and injection-type technology, which is applied in the field of medical materials, can solve the problems of pain and inflammation of patients, and achieve the effects of strong solubility and dissolution, avoiding re-injury, and improving utilization and efficacy.

Inactive Publication Date: 2018-09-21
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the human body is prone to inflammation after osteoporotic vertebral compression fractures, and the inflammation in different patients at different stages will be very different. The first way is to bring additional pain to the patient, and the second is to re-inject the drug when the condition recurs, causing the patient to suffer repeated pain.

Method used

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  • Injection type bone filling material and preparation method and using method thereof

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Embodiment 1

[0025] An injectable bone filling material, comprising β-tricalcium phosphate bone cement, solidification solution and drug-loaded microspheres, wherein the mass percentage of the drug-loaded microspheres is 6 wt%, and the particle size of the drug-loaded microspheres is 40-150nm, The solidification solution comprises the following components by mass percentage: 0.5wt% carboxymethyl chitosan, 8wt% citric acid, 1wt% polyvinyl alcohol, and the balance is deionized water; Fe 3 o 4 Nanoparticles are the core material, and a core-shell structure of poly N-isopropylacrylamide hydrogel is compounded on the surface of the core material, Fe 3 o 4 The surface of the nanoparticles is modified with hydroxypropyl-β-cyclodextrin, the drug is loaded on the hydroxypropyl-β-cyclodextrin, and the drug is imipenem. Its preparation method is as follows:

[0026] Using atom transfer radical method and basic ring-opening method on Fe 3 o 4 Hydroxypropyl-β-cyclodextrin is modified on the surfa...

Embodiment 2

[0028]An injectable bone filling material, comprising β-tricalcium phosphate bone cement, solidification solution and drug-loaded microspheres, wherein the mass percentage of the drug-loaded microspheres is 12wt%, and the particle diameter of the drug-loaded microspheres is 40-150nm. The solution includes the following components by mass percentage: 1.8wt% carboxymethyl chitosan, 15wt% citric acid, 2wt% polyvinyl alcohol, and the balance is deionized water; Fe 3 o 4 Nanoparticles are the core material, and a core-shell structure of poly N-isopropylacrylamide hydrogel is compounded on the surface of the core material, Fe 3 o 4 The surface of the nanoparticles is modified with hydroxypropyl-β-cyclodextrin, the drug is loaded on the hydroxypropyl-β-cyclodextrin, and the drug is a blend of resveratrol and levofloxacin. Its preparation method is as follows:

[0029] Using atom transfer radical method and basic ring-opening method on Fe 3 o 4 Hydroxypropyl-β-cyclodextrin is mo...

Embodiment 3

[0031] An injectable bone filling material, comprising β-tricalcium phosphate bone cement, solidification solution and drug-loaded microspheres, wherein the mass percentage of the drug-loaded microspheres is 10wt%, and the particle diameter of the drug-loaded microspheres is 40-150nm. The liquid comprises the following components by mass percentage: carboxymethyl chitosan 1.2wt%, citric acid 9wt%, polyvinyl alcohol 1.5wt%, and the balance is deionized water; Fe 3 o 4 Nanoparticles are the core material, and a core-shell structure of poly N-isopropylacrylamide hydrogel is compounded on the surface of the core material, Fe 3 o 4 The surface of the nanoparticles is modified with hydroxypropyl-β-cyclodextrin, the drug is loaded on the hydroxypropyl-β-cyclodextrin, and the drug is a blend of ciprofloxacin and sulbactam. Its preparation method is as follows:

[0032] Using atom transfer radical method and basic ring-opening method on Fe 3 o 4 Hydroxypropyl-β-cyclodextrin is mo...

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Abstract

The invention discloses an injection type bone filling material and a preparation method and using method thereof, and relates to the technical field of medical materials. The material comprises beta-tricalcium phosphate bone cement, curing liquid and medicine carrying micro beads, and the curing liquid comprises, by mass, 0.5-1.8 wt% of carboxymethyl chitosan, 8-15 wt% of citric acid, 1-2 wt% ofpolyving akohol and the balance of deionized water; Fe3O4 nano particles are taken as the core material of the medicine carry micro beads, the surface of the core material is coated with a layer of core-shell structure of poly N-isopropylacrylamide hydrogel, the surfaces of the Fe3O4 nano particles are modified with hydroxypropyl-beta-cyclodextrin, and medicines are loaded on the hydroxypropyl-beta-cyclodextrin. By means of the material, inflammation diminishing medicines can be injected into a fractured vertebral body along with the bone cement, subsequent releasing of the medicines can be externally controlled through a manner of magnetic hyperthermia according to the inflammation situation of a patient, medicine injection is not needed, and secondary hurting on the patient is prevented.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an injection-type bone filling material and a preparation method and application method thereof. Background technique [0002] Osteoporotic vertebral compression fractures are progressive bone decalcification and abnormal trabecular structure caused by osteoporosis. They are one of the fragility fractures in the elderly, accounting for 45% of osteoporotic fractures. Osteoporotic vertebral compression fractures are more likely to occur in the thoracolumbar and mid-thoracic segments of the spine, which can lead to kyphosis, intractable back pain, kyphosis, and other secondary complications. quality of life. The traditional treatment methods are long-term bed rest, drug therapy and wearing braces, but non-surgical treatment cannot effectively relieve pain, and long-term bed rest can lead to further aggravation of osteoporosis and complications, which brings a heavy nursin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/54A61L27/56A61N2/06A61N2/00
CPCA61L27/425A61L27/54A61L27/56A61L2300/41A61L2300/622A61L2400/06A61N2/002A61N2/06B33Y70/00B33Y80/00
Inventor 栾富钧
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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