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Spindle-shaped iron oxide nano material as well as preparation method and application thereof

A nano- and spindle-shaped technology of iron oxide, which is applied in the field of nanomaterials, can solve the problems of low saturation magnetization, low sensitivity, and difficulty in tumor tissue localization and retention, and achieve the effect of low cost and simple preparation process

Inactive Publication Date: 2020-08-28
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the synthesis and application of magnetic iron oxide nanomaterials have been studied in depth from the basic theory, preparation method to its application technology, but there are still the following key problems to be solved: (1) the inherent properties of magnetic iron oxide nanomaterials Small size and surface spin skew effect caused by low saturation magnetization, slow magnetic response and other defects are prominent, which affects its application performance in the field of biomedicine
(2) In the field of protein detection, signal detection using magnetic iron oxide nanoparticles in NMR systems is mostly limited to medical fields with high magnetic field strength. Troubled by problems such as easy reunion, it is also troubled by problems such as complex detection methods, long detection cycle, and low sensitivity
(3) Due to its small size, magnetic iron oxide nanomaterials are not easy to locate and stay in tumor tissue. When used as a passive targeting drug carrier, it is not conducive to the effective enrichment of anticancer drugs in the lesion, which limits its ability to load drugs. Aspects of application

Method used

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  • Spindle-shaped iron oxide nano material as well as preparation method and application thereof
  • Spindle-shaped iron oxide nano material as well as preparation method and application thereof
  • Spindle-shaped iron oxide nano material as well as preparation method and application thereof

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preparation example Construction

[0033] The invention provides a method for preparing a spindle-shaped iron oxide nanomaterial, comprising the following steps:

[0034] mixing phosphate compounds, sulfates, iron salts, and water, subjecting the resulting reaction solution to hydrothermal reaction, and drying to obtain a spindle-shaped iron oxide nanomaterial;

[0035] The molar ratio of the phosphate compound, sulfate and iron salt is (0.01~0.02): (1.5~1.8)×10 -4 :(5.5~9.5)×10 -4 ;

[0036] The temperature of the hydrothermal reaction is 180-220° C., and the time is 32-48 hours.

[0037] In the present invention, unless otherwise specified, the required preparation materials are commercially available products well known to those skilled in the art.

[0038]The invention mixes phosphate compound, sulfate, iron salt and water, and conducts hydrothermal reaction on the obtained reaction liquid. In the present invention, the phosphate compound is preferably sodium hydrogen phosphate, potassium hydrogen phosp...

Embodiment 1

[0050] Mix 0.0562g of sodium dihydrogen phosphate dihydrate, 0.1562g of anhydrous sodium sulfate and 10.76g of ferric chloride hexahydrate into a beaker, add a small amount of distilled water, conduct ultrasonic dissolution for 3 minutes, and put the dissolved solution into a volumetric flask , prepared into a 1000mL solution, then poured the prepared reaction solution into the reaction kettle, and packaged it; kept the packaged reaction kettle at 220°C for 48 hours; after the reaction kettle was naturally cooled to room temperature, poured out the reaction kettle For the supernatant, put the lower precipitated sample in the kettle into a beaker, and dry it at 80°C for 4 hours to obtain a sample, which is recorded as 1C.

Embodiment 2

[0052] The difference between this embodiment and Example 1 is only that the quality of sodium dihydrogen phosphate dihydrate, sodium sulfate anhydrous and ferric chloride hexahydrate is 2 times that of the corresponding raw materials in Example 1, and other conditions are the same as those in Example 1. 1. The obtained sample is designated as 2C.

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Abstract

The invention provides a spindle-shaped iron oxide nano material as well as a preparation method and application thereof, and belongs to the technical field of nano materials. According to the preparation method, a hydrothermal method is adopted, the spindle-shaped Fe2O3 nano material can be prepared by regulating and controlling the concentration of reactants and controlling the reaction temperature, and the spindle-shaped Fe2O3 nano material is controllable in size, regular in morphology and uniform in structure. The spindle-shaped Fe2O3 nano material prepared can achieve the material advantages of huge surface energy and the like, and has wide application prospects in the biomedical fields of bioanalysis and detection, electrochemical biosensors, cell and protein separation and recognition, magnetic resonance imaging, tumor magnetic hyperthermia, drug targeting and slow release, antibacterial effect and the like.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a spindle-shaped iron oxide nanomaterial and its preparation method and application. Background technique [0002] The magnetic iron oxide nanomaterial refers to the nanomaterial of iron oxide and its oxyhydroxide. According to the difference in valence state, crystal form and structure, the most common iron oxide nanomaterials can be divided into Fe 2 o 3 (α, β, γ phase), Fe 3 o 4 , FeO and FeOOH (α, β, γ, δ phase), etc. Among them, α-Fe 2 o 3 , γ-Fe 2 o 3 and Fe 3 o 4 Due to their high stability (including chemical and thermodynamics, etc.), anti-corrosion properties, catalytic activity, electrochemical properties, and sensing properties, nanomaterials have shown good practical value, and have been used in magnetic materials, chemical pigments, Active catalysts, gas sensors, electrode materials and other fields have been widely used. In recent years, research ...

Claims

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Application Information

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IPC IPC(8): C01G49/06B01J20/06B01J20/28B01J20/30
CPCB01J20/06B01J20/28004B01J20/28014C01G49/06C01P2002/72C01P2004/03C01P2004/04C01P2004/30C01P2004/61C01P2004/62
Inventor 刘小楠姚卫棠白雪园
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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