Magnetic nano-chains and preparation method thereof

A magnetic nano-chain and nano-particle technology, applied in the field of medicine, can solve the problems of lack of chemical groups, lack of drug-carrying capacity, application limitations of nano-chain structures, etc.

Inactive Publication Date: 2015-01-07
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the reported chain-like magnetic nanoparticles are either rigid structures that lack flexibility and bendability, or lack drug-loading capabilities, and lack chemical groups that can be targeted for modification.
Many of the above defects have limited the further application of the nanochain structure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of self-assembled oleic acid-coated ferric oxide nanochains by loading a static magnetic field

[0025] Precisely measure 3mL of Fe stored in n-hexane 3 o 4 OA, add 5mL ethanol, magnetically adsorb for 2min, discard the supernatant; add 3mL dimethyl sulfoxide (DMSO), and disperse evenly by ultrasonication in a water bath for 10min; In the syringe; take another 12.5mL of water into the beaker, and then quickly inject the solution in the syringe into the water, the probe is ultrasonic for 8min (power 1000W, ultrasonic 6s, pause 5s); put two magnets with a magnetic strength of 1.5T in the beaker On both sides, the organic solvent is removed by volatilization, the resulting solution is vacuum filtered through a polycarbonate membrane (Φ=180nm), and the filtrate is collected.

Embodiment 2

[0026] Example 2. Preparation of self-assembled oleic acid-coated ferric oxide nanochains by loading a static magnetic field

[0027] Precisely measure 1mL of Fe stored in n-hexane 3 o 4 OA, add 2mL ethanol, magnetically adsorb for 2min, discard the supernatant; add 1.5mL tetrahydrofuran (DMSO), and ultrasonically disperse evenly in a water bath for 3min; then add 20mg egg yolk phospholipid and pegylated phospholipid complex, and ultrasonically dissolve in a water bath , absorb the above solution into a glass syringe; take another 7.5mL of water into the beaker, and then quickly inject the solution in the syringe into the water, and ultrasonic the probe for 8min (power 1000W, ultrasonic 6s, pause 5s); A 1.5T magnet was placed on both sides of the beaker, and the organic solvent was evaporated to remove it. The resulting solution was vacuum filtered through a polycarbonate membrane (Φ=180nm), and the filtrate was collected.

Embodiment 3

[0028] Example 3: Using the method of loading a static magnetic field to prepare vincristine drug-loaded self-assembled ferric oxide nanochains coated with oleic acid

[0029] Accurately measure 2mL of Fe stored in n-hexane 3 o 4 OA, add 3mL ethanol, magnetically adsorb for 3min, discard the supernatant; add 4.5mL tetrahydrofuran (THF), and ultrasonically disperse evenly in a water bath for 7.5min; then add 50mg lauryl ether phosphate potassium (MAEPK), and ultrasonically dissolve in a water bath , and then add 2 mg of vincristine, and ultrasonically dissolve it in a water bath. Absorb the above solution into a glass syringe; measure another 9mL of water into a beaker, then quickly inject the solution in the syringe into the water, and ultrasonicate the probe for 5min (power 1200W, ultrasonic for 10s, pause for 10s); Magnets are placed on both sides of the beaker, the organic solvent is removed by volatilization, the resulting solution is vacuum filtered through a polycarbon...

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Abstract

The invention discloses magnetic nano-chains with a medicine-carrying function and a preparation method of the magnetic nano-chains. The magnetic nano-chains are multi-unit chain assembled carriers and are characterized in that a basic unit is oleic acid modified ferroferric oxide; a dispersion medium is water or buffer solution; a surfactant is one or more of soybean lecithin, lecithin, synthetic phospholipids, hydrogenated lecithin, polyethylene glycol phospholipids, poloxamer, potassium polyoxyethylene laurylether phosphate or cocoalkanoylamido propyl betaine. Ferroferric oxide nanoparticles which are singly dispersed and are modified by superparamagnetic oleic acid are self-assembled under the inductive effect of a magnetic field to form the magnetic nano-chains, and the magnetic nano-chains can be used as a targeting preparation and contrast mediums for nuclear magnetic resonance, so that the process of nanoscale carriers in cells and organisms can be observed; meanwhile, the magnetic nano-chains have wide application prospects in magnetic targeting, magnetic hyperthermia and the like.

Description

technical field [0001] The invention relates to a nano chain and a preparation method thereof, in particular to a magnetic nano chain and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] In recent years, the successful development of small size, monodisperse, narrow distribution, high saturation magnetization, superparamagnetic and surface-modified magnetic nanoparticles has provided new opportunities for basic and applied research in biomedical diagnosis and treatment. . The application of magnetic nanoparticles in the living body mainly includes three aspects: nuclear magnetic resonance contrast agent, magnetic hyperthermia, and magnetic targeting; it can also observe the process of nanoscale carriers in cells and living organisms to achieve the purpose of integration of diagnosis and treatment. [0003] The design of magnetic nano-drug carriers usually uses superparamagnetic magnetic nanoparticles with high saturat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/12A61K47/02A61K47/34A61K49/08A61K41/00A61K49/18A61K9/00A61P35/00
Inventor 熊非田吉来顾宁张少华
Owner SOUTHEAST UNIV
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