Medical magnetic hyperthermia copper-nickel alloy and preparation method thereof

A technology of copper-nickel alloy and magnetic hyperthermia, which is applied in the field of medical alloys, can solve the problems that the uniformity and compactness of the material are not well realized, and achieve good relative magnetic permeability, reduce segregation, and ensure safety. Effect

Active Publication Date: 2019-11-19
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the heat generation performance of the magnetic medium material in the prior art, the uniformity and compactness of the material have not been well realized, and the present invention provides a kind of magnetic medium with good compactness, rapid heat generation and uniform heat distribution in the alternating magnetic field. A medical magnetic thermotherapy copper-nickel alloy and a preparation method thereof, which also retains the self-temperature control characteristics of the magnetic induction heat seed and good biocompatibility characteristics

Method used

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  • Medical magnetic hyperthermia copper-nickel alloy and preparation method thereof
  • Medical magnetic hyperthermia copper-nickel alloy and preparation method thereof
  • Medical magnetic hyperthermia copper-nickel alloy and preparation method thereof

Examples

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Effect test

Embodiment 1

[0035] A preparation method of medical magnetic hyperthermia copper-nickel alloy, comprising the steps of:

[0036] 1) According to the mass percentage of raw materials, put 28.2% Cu, 70% Ni, 1.7% Fe and absolute ethanol (absolute ethanol is not included in the raw materials, and the mass ratio of absolute ethanol to copper is 1:5) into the planetary formula The ball mill is used for ball milling, and the speed of the machine is adjusted to 60rpm in revolution and 110rpm in rotation. In order to prevent oxidation, nitrogen gas needs to be introduced as a protective gas, and the ball mill is shut down for 20 minutes every 45 minutes for a total of 4 hours of ball milling. After drying, alloy powder (particle size is about 16 μm) is obtained;

[0037]2) Put the evenly stirred mixed powder into a high-temperature induction furnace, set the temperature at 1480°C, feed nitrogen as a protective gas, make the induction furnace pressure 260Pa, carry out vacuum melting and keep it warm ...

Embodiment 2

[0047] A preparation method of medical magnetic hyperthermia copper-nickel alloy, comprising the steps of:

[0048] 1) According to the mass percentage of raw materials, put 25.1% Cu, 73% Ni, 1.8% Fe and absolute ethanol (absolute ethanol is not included in the raw materials, and the mass ratio of absolute ethanol to copper is 1:5) into the planetary formula The ball mill is used for ball milling, and the speed of the machine is adjusted to 55 rpm for revolution and 115 rpm for rotation. In order to prevent oxidation, nitrogen gas needs to be introduced as a protective gas. Every 50 minutes of ball milling, the machine is shut down for 30 minutes, and a total of 4 hours of ball milling is obtained. After drying, alloy powder (particle size is about 12 μm) is obtained;

[0049] 2) Put the evenly stirred mixed powder into a high-temperature induction furnace, set the temperature at 1530°C, feed nitrogen gas as a protective gas, make the induction furnace pressure 220Pa, carry out...

Embodiment 3

[0059] A preparation method of medical magnetic hyperthermia copper-nickel alloy, comprising the steps of:

[0060] 1) According to the mass percentage of raw materials, put 26.3% Cu, 71.7% Ni, 1.9% Fe and absolute ethanol (absolute ethanol is not included in the raw materials, and the mass ratio of absolute ethanol to copper is 1:5) into the planetary formula The ball mill is used for ball milling, (adjust the machine speed to 65rpm for revolution and 105rpm for autorotation). In order to prevent oxidation, nitrogen gas needs to be introduced as a protective gas. Every 40min of ball milling, stop for 15min, and ball mill for 5h in total. After drying, alloy powder (particle size is about 15μm) is obtained;

[0061] 2) Put the evenly stirred mixed powder into a high-temperature induction furnace, set the temperature at 1500°C, feed nitrogen as a protective gas, make the induction furnace pressure 300Pa, carry out vacuum melting and keep it warm for 80min; then lower the tempera...

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Abstract

The invention discloses a medical magnetic hyperthermia copper-nickel alloy and a preparation method thereof. The medical magnetic hyperthermia copper-nickel alloy is prepared from the following raw material formula in percentage by weight: 15-25% of Cu, 50-60% of Ni, 0.05-0.08% of Sn, 1-1.3% of Fe, 0.01-0.015% of B, and 0.01-0.02% of Li; and during preparation, firstly, Cu, Ni and Fe raw materials are milled, subjected to vacuum smelting, and cooled to 1200-1350 DEG C, Sn, B and Li are added, uniform electromagnetic mixing is conducted, water cooling is conducted to the room temperature, andan alloy ingot is obtained; the alloy ingot is turned into fines and then crushed to obtain alloy powder; vacuum sintering is conducted after extrusion molding; and homogenization treatment is conducted. The produced copper-nickel alloy is fine and uniform in grain, can be used for tumor hyperthermia, magnetic induction thermoseed materials processed through the copper-nickel alloy is good in compactness, in an alternating magnetic field, the thermal production capability is high, thermal distribution is uniform, and the self temperature control property and the good biocompatibility of magnetic induction thermoseeds are further retained.

Description

technical field [0001] The invention relates to the field of medical alloys, in particular to a medical magnetic thermotherapy copper-nickel alloy and a preparation method thereof. The alloy can be used for making magnetic induction heat seeds, and the magnetic induction heat seeds can be used for treating tumors. Background technique [0002] Cancer has become the number one cause of death among Chinese citizens. Malignant tumors have become a major disease that seriously threatens human life. Although traditional cancer treatment methods (surgery, radiotherapy, and chemotherapy) have certain curative effects, surgery is mainly suitable for patients with early-stage cancer, which usually brings pain to patients and is easy to spread after surgery, while radiotherapy and chemotherapy have obvious Toxic and side effects; therefore, it is necessary to develop green, safe and efficient new cancer therapy. Medical research has shown that due to abnormal angiogenesis and structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C19/03C22C1/02C22C1/04C22F1/10A61F7/12A61K41/00A61P35/00
CPCA61F7/12A61F2007/126A61K41/0052A61P35/00C22C1/02C22C1/0433C22C19/002C22C19/03C22F1/10
Inventor 李静王者陈燕康梓彬袁振
Owner SOUTH CHINA UNIV OF TECH
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