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Self-temperature-control magnetic nanowire and preparation method thereof

A magnetic nanometer and self-temperature control technology, which is applied in chemical instruments and methods, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low heat generation and agglomeration of magnetic nanoparticles, and achieve quality controllable, Effects of preventing agglomeration and improving heat production rate

Active Publication Date: 2021-03-16
重庆海士智能科技研究院有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] In order to solve the problems of low heat generation rate and agglomeration of magnetic nanoparticles, the invention provides a self-temperature-controlling magnetic nanowire and its preparation method

Method used

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  • Self-temperature-control magnetic nanowire and preparation method thereof
  • Self-temperature-control magnetic nanowire and preparation method thereof
  • Self-temperature-control magnetic nanowire and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing self-temperature-controlled magnetic nanowires, comprising the steps of:

[0035] Step 1, the aluminum foil is anodized twice to make an aluminum anodized microporous template;

[0036] Step 2, depositing zinc-cobalt-chromium ferrite hydroxide in the microchannels of the aluminum anodic oxidation microchannel template by chemical co-precipitation method, and forming zinc-cobalt-chromium ferrite magnetic nanowires after sintering;

[0037] Step 3: removing the aluminum anodic oxidation micro-channel template by corrosion, and performing surface hydrophobization treatment on the zinc-cobalt-chromium ferrite magnetic nanowires to prepare the self-temperature-controlling magnetic nanowires.

Embodiment 2

[0039] A method for preparing self-temperature-controlled magnetic nanowires, comprising the steps of:

[0040] Step 1. The aluminum foil is anodized twice to make an aluminum anodized microporous template:

[0041] Take thin aluminum foil with a purity ≥ 99.95%, the thickness of the thin aluminum foil is 0.05-0.1mm, the surface is polished and cut into 50mm×50mm squares, and the cut thin aluminum foil is immersed in H with a molar concentration of 0.1-0.5mol / L 2 SO 4 Carry out an anodic oxidation in an aqueous solution, the primary oxidation voltage is 24-57V, and the oxidation time is 5-20min; the aluminum foil after primary anodization is immersed in a mixed solution of phosphoric acid and chromic acid to remove the primary oxide film on the surface of the aluminum foil, phosphoric acid The mass concentration of phosphoric acid in the mixed solution with chromic acid is 4-5 wt%, and the mass concentration of chromic acid is 1.2-1.4 wt%.

[0042] Then the aluminum foil was...

Embodiment 3

[0047] A method for preparing self-temperature-controlled magnetic nanowires, comprising the steps of:

[0048] Step 1. The aluminum foil is anodized twice to make an aluminum anodized microporous template:

[0049] Take thin aluminum foil with a purity ≥ 99.95%, the thickness of the thin aluminum foil is 0.05-0.1mm, the surface is polished and cut into 50mm×50mm squares, and the cut thin aluminum foil is immersed in H with a molar concentration of 0.1-0.5mol / L 2 SO 4 Carry out an anodic oxidation in an aqueous solution, the primary oxidation voltage is 24-57V, and the oxidation time is 5-20min; the aluminum foil after primary anodization is immersed in a mixed solution of phosphoric acid and chromic acid to remove the primary oxide film on the surface of the aluminum foil, phosphoric acid The mass concentration of phosphoric acid in the mixed solution with chromic acid is 4.5-5.5 wt%, and the mass concentration of chromic acid is 1.3-1.5 wt%.

[0050] Then the aluminum foil...

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Abstract

The invention relates to a self-temperature-control magnetic nanowire and s preparation method thereof, and belongs to the technical field of tumor magnetic induction thermotherapy. In order to solvethe problems of low heat production rate and agglomeration of magnetic nanoparticles, the invention provides a preparation method of a self-temperature-control magnetic nanowire. The preparation method comprises the following steps: anodizing an aluminum foil to prepare an aluminum anodized micro-channel template, depositing zinc-cobalt-chromium ferrite hydroxide in the micro-channel template by using a chemical coprecipitation method, performing sintering to form a zinc-cobalt-chromium ferrite magnetic nanowire, and carrying out surface hydrophobization treatment on the magnetic nanowire. Theself-temperature-control magnetic nanowire prepared by the invention has the diameter of 5-45nm, the length of 5-30mu m and the Curie temperature point of 42-45 DEG C, is stable in chemical propertyand excellent in magnetic property, has the Curie point temperature meeting the magnetic hyperthermia requirement, has the advantages of high heat yield, low possibility of agglomeration, good performance consistency and good biocompatibility, and can be used for batch production of magnetic nano media and magnetic hot seeds for magnetic hyperthermia.

Description

technical field [0001] The invention belongs to the technical field of tumor magnetic induction hyperthermia, and in particular relates to a self-temperature-controlling magnetic nanowire and a preparation method thereof. Background technique [0002] The main method of tumor treatment at home and abroad is still mainly surgery, supplemented by radiotherapy and chemotherapy. With the improvement of medical level, the treatment methods of tumor continue to expand, and new treatment methods emerge in endlessly. In recent years, tumor hyperthermia technology has developed rapidly, and clinical application has achieved remarkable results. The toxic and side effects are relatively small, and the pain of patients is also very slight, which has attracted great attention from researchers and clinicians. Studies have shown that: in a high-temperature thermal environment, blood flow in tumor tissue is slow, resistance is large, heat dissipation is difficult, heat is easy to accumulate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G51/00A61K41/00A61P35/00
CPCC01G51/006A61K41/0052A61P35/00C01P2004/16C01P2006/42
Inventor 张洪泉张凯
Owner 重庆海士智能科技研究院有限公司
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