5 results about "Liquid base cytology" patented technology

Disclosed herein is a filter fused guider device (100) for the application of liquid- based cytology device for PAP smear preparation in automated instrument The guider device (100) comprising an outer body (102). The guider device (100) also comprising a nylon filter mesh (104) fitted inside the outer body (102) and the nylon filter mesh (104) allowing separation and capturing of the particles / cells of the sample. The guider device (100) also comprising a rubber seal (106) fitted over the nylon filter mesh (104) and the outer body (102) and the rubber seal (106) capable of fixing the nylon filter mesh (104) to the outer body (102).

The present invention relates to the technical field of cytopathology detection, and in particular to a quality control product for cervical liquid-based cytology projects and a preparation method thereof; the product comprises quality control cells and a cervical liquid-based cytology preservation fluid, wherein the quality control cells are extracted from cervical liquid-based cytology samples; the inventors prepare the quality control product by collecting samples remaining after routine clinical pathology laboratory testing, and perform dynamic observation and analysis to ultimately obtain the above-mentioned quality control product for cervical liquid-based cytology projects. The quality control product is prepared by classifying, breaking up, filtering, washing, fixing, shedding, removing residues, extracting and other steps of a plurality of cervical exfoliated liquid-based cytology samples from different individuals, without causing mutual influence or interference, and can be preserved for a long time, having the feasibility of being used as a quality control product, and having good stability, and can be used as a quality control product in routine quality control in clinical pathology laboratories.

This invention discloses a fully automated liquid-based cytology slide preparation and staining machine, comprising a frame, a turntable assembly, a lateral movement assembly, a lifting assembly, a push rod assembly, a solenoid valve assembly, a waste collection assembly, and a waste liquid collection assembly. The turntable assembly integrates sample bottles, pipette tips, slide clamps, and sedimentation baskets, enabling multi-channel sample loading. The lateral movement assembly and the lifting assembly work together to perform pipetting, sample addition, filter placement and removal, and staining operations. The push rod assembly drives the turntable assembly to perform centrifugal slide preparation. The solenoid valve assembly controls the actions of each actuator. The waste collection assembly and waste liquid collection assembly respectively achieve centralized treatment of waste and waste liquid. This invention integrates centrifugal slide preparation and automatic staining functions. The equipment has a compact layout and small footprint. It uses standard consumables and operates fully automatically. The multi-channel design improves slide preparation and staining efficiency, solving the technical problems of high cost and limited functionality of existing TCT equipment and cumbersome processes and high operational requirements of LCT equipment. It is suitable for liquid-based cytology testing scenarios in pathology departments.

The utility model discloses a gynecological liquid-based cytological examination device, which relates to the technical field of gynecological examination, and comprises a vagina dilation mechanism, a vagina dilation adjusting mechanism is arranged above the vagina dilation mechanism, a cell collection mechanism is arranged on the rear side of the vagina dilation adjusting mechanism, and the cell collection mechanism comprises an L-shaped hanging plate. A first semicircular groove is formed in the bottom of the vertical position of the L-shaped hanging plate, a detachable movable plate is movably installed on the right side of the bottom of the vertical position of the L-shaped hanging plate, a second semicircular groove is formed in the top of the detachable movable plate, and a cervical brush connecting rod is arranged between the first semicircular groove and the second semicircular groove in a penetrating mode. The vaginal dilation mechanism, the vaginal dilation adjusting mechanism, the L-shaped hanging plate, the cervix brush connecting rod and the conical cervix brush head are matched with one another, so that a vaginal dilation structure and a collection and examination structure are unified, the cervix cell sample collection work can be directly and quickly carried out after vaginal dilation, and the collection and examination efficiency is improved.

The invention discloses a pathological image cervical cancer screening model construction method based on liquid-based cytology, and relates to the technical field of cervical cancer screening, cellular level detection is realized by using a YOLO model, cell detection results are aggregated into WSI level feature vectors and macroscopic statistical features through a feature statistics module, and the WSI level feature vectors and the macroscopic statistical features are used for screening the cervical cancer. The training module is respectively used for training the WSI secondary diagnosis model and the pre-diagnosis device, generating an optimized threshold value of the routing state controller based on model training data and a training result, initializing parameters of the routing state controller by utilizing the optimized threshold value, and sending the initialized parameters to the pre-diagnosis device; combining the trained cell detection model, the feature statistics module, the WSI secondary diagnosis model and the pre-diagnosis device into a cervical cancer screening model, and processing a to-be-screened WSI image based on the cervical cancer screening model to generate a screening conclusion; through cooperative work of multiple modules, the cervical cancer screening efficiency and accuracy are remarkably improved.