The application discloses a fluorinated
monosaccharide derivative and a synthesis method and application thereof. The fluorinated
monosaccharide derivative is composed of three parts, the first part is a 1-substituted
monosaccharide group, the second part is a
fluorine signal source perfluoro-t-butyl
ether group, and the third part is a
triazole ring connecting the two. The fluorinated monosaccharide derivative of the application retains the 2-hydroxyl and 6-hydroxyl of the monosaccharide, thereby not affecting the recognition of the monosaccharide in the body, and having good water
solubility and
biocompatibility. The derivative contains nine magnetically equivalent
fluorine-19, can produce a single and strong
fluorine signal, and avoids problems such as fluorine
signal splitting or low fluorine atom utilization. The fluorine
signal strength has a good
linear relationship with the concentration of the compound, which provides a basis for
in vivo quantification 19 F MRI. 19 F
MRI imaging of HepG2 cells has the potential to be used as a tumor selective 19 F
MRI contrast agent.