Lubricity coatings preparation method on the medical catheter polymers surface

A technology for polymer materials and medical catheters, which is applied in the field of preparation of synthetic lubricating polymer coatings on the surface of polymer materials for medical catheters, can solve problems such as grafting reactions of harmful substances, difficult to control, etc., and improve blood compatibility. , easy to control, eliminate the effect of harmful substances

Inactive Publication Date: 2009-06-17
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for preparing a lubricating coating on the surface of a medical catheter polymer material, which solves the problems of introducing harmful substances and difficult control of grafting reactions in the preparation method in the prior art.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 Acrylamide is the surface coating preparation of hydrophilic polymer monomer

[0034] Take a clean polyurethane film and activate it in 20mg / L ozone for 15min. 10 g of analytically pure acrylamide, 90 g of distilled water and 0.5 g of castor oil were respectively added to a 200 ml three-necked flask. Stir magnetically for 30 minutes in a 30 °C oil bath. Take the newly activated polyurethane film reaction solution and immerse it at 30°C for 24h. Under the atmospheric environment, the impregnated polyurethane film was reacted at 200mW / cm2 for 30min. Add water, acrylic acid, nitric acid, methylpyrrolidone and ammonium cerium nitrate in sequence in a 200ml Erlenmeyer flask. After the reaction, the film was washed in distilled water for 15 hours at a temperature of 80°C, and the distilled water was replaced at least 10 times, then ultrasonically cleaned in ethanol for 30 minutes, vacuum-dried at 60°C to constant weight, and stored for use

[0035] The contac...

Embodiment 2

[0036] Embodiment 2 N-vinylpyrrolidone is the surface film preparation example of hydrophilic polymer monomer

[0037] Take a clean polyurethane film and activate it in 10mg / L ozone for 20 minutes. 10 g of N-vinylpyrrolidone, 90 g of methyl ethyl ketone and 0.1 g of benzoyl peroxide were added to a 200 ml three-necked flask. Stir magnetically for 30 min in a 30 °C oil bath. Take the newly activated polyurethane film reaction solution and immerse it at 30°C for 24h. In the atmospheric environment, take the impregnated polyurethane film at 200m W / cm 2 Under reaction 30min. After the reaction, the film was washed in distilled water for 15 hours at 80°C, and the distilled water was replaced at least 10 times, then ultrasonically cleaned in ethanol for 30 minutes, vacuum-dried at 60°C to constant weight, and stored for use

[0038] The contact angle hysteresis of the prepared lubricating coating was 24.3°, and the coefficient of dynamic friction decreased from 0.23 to 0.083 und...

Embodiment 3

[0039] Embodiment 3 acrylamide is the surface film preparation example of hydrophilic polymer monomer

[0040] Take a clean polyamide film at 15mW / cm 2 UV light, N 2 The reaction was carried out under the atmosphere for 10 minutes. 10 g of analytically pure acrylamide, 90 g of distilled water, 0.5 g of castor oil, and 3 g of glycidyl acrylate were respectively added to a 200 ml three-necked flask. Stir magnetically for 30 min in an oil bath at 40 °C. Take the newly activated polyamide film reaction solution and immerse it at 20°C for 36h. The impregnated polyamide film was reacted under electron beam radiation for 10 minutes. After the reaction, the film was washed in distilled water for 20 hours at a temperature of 80°C, and the distilled water was replaced at least 10 times, then ultrasonically cleaned in ethanol for 30 minutes, vacuum-dried at 60°C to constant weight, and stored for use

[0041] The contact angle hysteresis of the prepared lubricating coating was 17.5°...

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PUM

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Abstract

The invention discloses a method for preparing a lubricant coating on the surface of polymer materials of a medical catheter, which comprises the following steps: (A), pretreating the surface of the polymer materials of the medical catheter, so as to obtain hydrophilic adsorption active sites; (B), soaking the pretreated polymer materials of the medical catheter in step (A) into a prepared precursor solution of the lubricant coating for adsorption; and (C), performing grafting reaction on the soaked polymer materials of the medical catheter in step (B), and washing and drying the polymer materials of the medical catheter. The method can be widely used for preparing medical polymer materials and coating materials on the surface of a medical apparatus.

Description

technical field [0001] The invention belongs to the field of surface modification methods of medical polymer materials, and in particular relates to a preparation method for synthesizing a lubricating polymer coating on the surface of a medical catheter polymer material. Background technique [0002] Medical catheters play an important role in the fields of disease diagnosis and interventional therapy, sewage discharge, and laboratory tests. Among them, interventional catheters, such as coronary artery catheters, coronary artery dilation tubes, balloon catheters, etc., are relatively important components used in interventional medicine. Interventional medicine is a technique that is simple, safe, effective, minimally invasive and has few complications. It has become one of the three major clinical medicines along with surgery and internal medicine. Among the medical catheters used in clinical practice, interventional catheters have high technical content and high added valu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/04
Inventor 顾宁周雪锋江筱莉
Owner SOUTHEAST UNIV
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