Method for manufacturing artificial blood vessels with double-layered structures and application of artificial blood vessels
A technology of artificial blood vessels and double-layer structure, which is applied in the direction of human tubular structure devices, blood vessels, veterinary instruments, etc., can solve the problems of hindering the regeneration of pseudo-natural blood vessels, the inability to regenerate smooth muscle layers, and the lack of orientation of smooth muscle layers. Blood compatibility, safe and non-toxic materials, and the effect of avoiding aneurysm
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Embodiment 1
[0011] Example 1: Preparation of PGA oriented microfiber inner layer and PLA random nanofiber outer double-layer structure artificial blood vessel
[0012] Preparation of the inner layer spinning solution: Weigh 1.0 g of PGA with a number average molecular weight of 100,000, add it to 10 ml of hexafluoroisopropanol, stir until it dissolves evenly, and prepare a PGA solution with a concentration fraction of 10% (m / v).
[0013] Preparation of the outer layer spinning solution: Weigh 2.0 g of PLA with a number average molecular weight of 300,000, add it to 10 ml of chloroform, stir until it dissolves evenly, and prepare a solution with a concentration fraction of 20% (m / v) PLA.
[0014] Preparation of the inner layer of the artificial blood vessel: the wet spinning of the inner layer was carried out in a fume hood at room temperature. Connect a cylindrical receiving rod with a diameter of 1.0 mm to a rotating motor. The PGA spinning solution was sucked into the syringe, and the ...
Embodiment 2
[0016] Example 2: Preparation of double-layer structure artificial blood vessel with PLGA oriented microfiber inner layer and PLCL random nanofiber outer layer
[0017] Preparation of the inner layer spinning solution: Weigh 1.2 grams of PLGA (LA / GA, 75:25), add it to 10 ml of chloroform, stir until it dissolves evenly, and prepare a PLGA solution with a concentration fraction of 12% (m / v).
[0018]Preparation of the outer layer spinning solution: Weigh 0.8 g of PLCL (50:50), add it into 10 ml of dichloromethane, stir until it dissolves evenly, and prepare a PLCL solution with a concentration fraction of 8% (m / v).
[0019] Preparation of the inner layer of the artificial blood vessel: the wet spinning of the inner layer was carried out in a fume hood at room temperature. Connect a cylindrical receiving rod with a diameter of 2.0mm to the rotating motor. The 12% PLGA spinning solution was sucked into the syringe, and the needle of the syringe was inserted into the edible oil i...
Embodiment 3
[0021] Example 3: Preparation of artificial blood vessel with double-layer structure of silk fibroin-oriented microfiber inner layer and PCL random nanofiber outer layer
[0022] Preparation of inner layer spinning solution: Weigh 2 grams of silk fibroin freeze-dried product, add to 10mL hexafluoroisopropanol solvent, stir until dissolved evenly, centrifuge at 10000rpm to discard the precipitate, and collect the concentration fraction to be 20% (m / v ) of SF solution.
[0023] Preparation of the outer layer spinning solution: Weigh 1.2 g of PCL and add it to 12 ml of chloroform / methanol (5:1), stir until it dissolves evenly, and obtain a PCL solution with a concentration fraction of 10% (m / v).
[0024] Preparation of the inner layer of the artificial blood vessel: the wet spinning of the inner layer was carried out in a fume hood at room temperature. Connect the 4.0mm diameter cylindrical receiving rod to the rotating motor. The silk fibroin spinning solution is sucked into t...
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