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Preparation method of triptolide and ramification composition thereof

A technology for triptolide and derivatives, which is applied in the field of preparation of triptolide and its derivative compositions, can solve the problems of harsh reaction conditions, low yield, lack of wild resources of triptolide and the like, and achieves a short production cycle. , the effect of high yield

Inactive Publication Date: 2013-06-19
HUAQIAO UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the total chemical synthesis of TP has many successful routes, the routes are too long (more than 15 steps), the reaction conditions are harsh, and the yield is low; or it is necessary to use some toxic raw materials, and It is not conducive to drug safety and cannot realize green industrial production
Since the semi-synthetic method still needs to use the synthetic precursor of the plant, it is difficult to fundamentally solve the problem of the shortage of wild resources of Tripterygium wilfordii by chemical synthesis.

Method used

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  • Preparation method of triptolide and ramification composition thereof
  • Preparation method of triptolide and ramification composition thereof
  • Preparation method of triptolide and ramification composition thereof

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Embodiment Construction

[0022] A preparation method of triptolide and its derivative composition, comprising the following steps:

[0023] Step 1: Take the new root system of the wild two-year-old Tripterygium wilfordii seedlings after secondary cultivation at room temperature as explants, and cultivate callus tissue on MS medium. The cultivation conditions are: light intensity 1500lx-2500lx, temperature 25±1°C , 18-25 days to form a callus; the specific operation method is as follows:

[0024] The new root system of the wild two-year-old Tripterygium wilfordii seedlings in Taining, Fujian Province after secondary cultivation at room temperature was used as explants, placed under tap water, rinsed with running water for 3 hours, and then placed in distilled water containing a small amount of surfactant. Stir on a magnetic stirrer at low speed for 2 hours. After taking it out, rinse it twice with distilled water, then use 5% sodium hypochlorite solution, soak and shake for 8 minutes. Discard the sod...

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Abstract

The invention provides a preparation method of triptolide and ramification and composition of the triptolide. After an elicitor plays a role in tripterygium suspended cell sap, a high yield of triptolide and ramification of the triptolide can be gotten. The extractive gotten by the method has a good effect on inhibiting tumors, a hepatitis b virus and a human immunodeficiency virus (HIV); the extractive can be prepared into soft capsules, or hard capsules, or dropping pills or troches, or dispersible tablets, or granules, or injection, or oral liquid, or suppository which are applied in oral or skin or mucous membrane or rectal way, by that the extractive is used for being solely or being matched with other drugs or adding auxiliary materials which can be acceptable in pharmacy.

Description

【Technical field】 [0001] The invention specifically relates to a preparation method of triptolide and its derivative composition. 【Background technique】 [0002] Tripterygium wilfordii Hook.F. belongs to Euonymus family. It is mainly produced in Zhejiang, Jiangsu, Anhui, Fujian and other places, especially in Taining, Fujian. Tripterygium wilfordii has a medicinal history of hundreds of years in our country. It is widely used in rheumatoid arthritis, glomerulonephritis, systemic lupus erythematosus, leprosy, autoimmune diseases and skin diseases. There are at least 100 kinds of ingredients in tripterygium wilfordii. About 70 of them have different pharmacological effects; and the phytochemical components of Tripterygium wilfordii can be roughly divided into 3 categories: alkaloids (such as nicotinic sesquiterpenes, tripterine, tripterine, tripterygium, etc.) , diterpenoids (such as triptolide, B, etc.) and triterpenes (such as triptolide, triptolide A, lactone B, etc.). Am...

Claims

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Application Information

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IPC IPC(8): C07J73/00C07J63/00A61P35/00A61P35/02A61P31/20A61P31/18A01H4/00
Inventor 张景红王金海
Owner HUAQIAO UNIVERSITY
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