Tripterygium glycoside-containing micro-emulsified gel transdermal preparation and preparation method thereof

A technology of tripterygium glycosides and transdermal preparations is applied in the field of microemulsion gel transdermal preparations containing tripterygium glycosides and its preparation, and can solve the problems of low viscosity, inconvenient use of transdermal drug carriers, strong fluidity, etc. problem, to achieve the effect of simple process, promotion of transdermal absorption performance, and less skin irritation

Inactive Publication Date: 2012-05-23
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current microemulsion system still has the following defects: low viscosity, strong fluidity, inconvenient use as a transdermal drug carrier, etc.

Method used

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  • Tripterygium glycoside-containing micro-emulsified gel transdermal preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of tripterygium glycosides microemulsion gel transdermal system:

[0021] Prescription composition:

[0022] Tripterygium glycosides 0.8g Oleic acid 1.6g Labrasol 1.8g Transcutol P 1.8g Pharmasolve 1.8g water 2.6g Laurocaprazine 0.2g Carbomer 971 0.2g

[0023] After mixing the surfactant and the co-surfactant evenly, add the oil phase, mix well by stirring, oscillating, ultrasonic or vortex to form a blank microemulsion concentrate, then add water, mix well and add tripterygium glycosides, Fully dissolved tripterygium glycosides microemulsion evenly and transparently; accurately weigh the prescription amount of gel matrix, add it to water, stir and let it stand to make it fully swell and disperse evenly, slowly add the tripterygium glycosides microemulsion into it, and Stir evenly, and adjust the pH value to 6-10.

[0024] Physicochemical properties of tripterygium glycosides microemulsion ...

Embodiment 2

[0035] Prescription composition:

[0036] Tripterygium glycosides 0.8g MIGLYOL 812N 2.0g Tween 80 2.2g ethanol 2.2g Pharmasolve 2.2g water 1.0g Laurocaprazine 0.2g Carbomer 971 0.2g

[0037] After mixing the surfactant and the co-surfactant evenly, add the oil phase, mix well by stirring, oscillating, ultrasonic or vortex to form a blank microemulsion concentrate, then add water, mix well and add tripterygium glycosides, Fully dissolved tripterygium glycosides microemulsion evenly and transparently; accurately weigh the prescription amount of gel matrix, add it to water, stir and let it stand to make it fully swell and disperse evenly, slowly add the tripterygium glycosides microemulsion into it, and Stir evenly, and adjust the pH value to 6-10.

[0038]

Embodiment 3

[0040] prescription composition

[0041] Tripterygium glycosides 0.8g olive oil 1.2g polyoxyethylene castor oil 2.0g polyethylene glycol-400 2.0g 1,3-propanediol 2.0g water 2.4g Menthol 0.2g Carbomer 940 0.2g

[0042] After mixing the surfactant and the co-surfactant evenly, add the oil phase, mix well by stirring, oscillating, ultrasonic or vortex to form a blank microemulsion concentrate, then add water, mix well and add tripterygium glycosides, Fully dissolved tripterygium glycosides microemulsion evenly and transparently; accurately weigh the prescription amount of gel matrix, add it to water, stir and let it stand to make it fully swell and disperse evenly, slowly add the tripterygium glycosides microemulsion into it, and Stir evenly, and adjust the pH value to 6-10.

[0043]

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Abstract

The invention belongs to the technical field of medicinal preparations and relates to a tripterygium glycoside-containing micro-emulsified gel transdermal preparation and a preparation method thereof. The preparation method is characterized in that a gel matrix is added into microemulsion and the mixture is further processed into the tripterygium glycoside-containing micro-emulsified gel transdermal preparation. The tripterygium glycoside-containing micro-emulsified gel transdermal preparation comprises: by mass, 0.1 to 15% of tripterygium glycoside, 15 to 20% of one or more surfactants, 30 to 40% of one or more auxiliary surfactants, 15 to 25% of oil phases, 15 to 25% of water, 0.5 to 2% of one or more transdermal absorption promoters, and 0.5 to 5% of one or more gel base materials. Thetripterygium glycoside-containing micro-emulsified gel transdermal preparation is semitransparent or transparent, has nattier blue opalescence and a pH value of 6 to 10 and can form micro-emulsion having particle sizes of 10 to 100nm, can be processed into pasters so that drug transdermal delivery is realized, has low skin irritation, can be prepared by the simple preparation method, and has stable quality and good drug transdermal absorption promotion performances.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a microemulsion gel transdermal drug delivery system, in particular to a microemulsion gel transdermal preparation containing tripterygium glycosides and a preparation method thereof. Background technique [0002] Tripterygium wilfordii is the root of Euonymus plant Tripteryglum (Tripteryglum. wilfordii. Hook. f), bitter, pungent, cold in nature. It was first recorded in "Shen Nong's Materia Medica", which has the effects of purging heat and detoxification, expelling wind and dampness, dredging meridian and activating collaterals, reducing swelling and pain, killing insects and relieving itching. According to research and clinical application results in recent years, its main pharmacological effects include anti-inflammatory, antibacterial, immunosuppressive, promoting blood circulation, removing blood stasis, and anti-cancer. Since Tripterygium wilfordii was used in cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K9/107A61P17/02A61P17/04A61P29/00A61P37/02
Inventor 方晓玲王霄沙先谊
Owner FUDAN UNIV
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