Tripterygium glycosides extract and its extraction process

A tripterygium wilfordii polyglycoside and a technology for an extraction method are applied in the field of plant extracts and extraction thereof, and can solve the problems of low content of medicinal components of the triptolide wilfordii polyglycoside, difficult large-scale industrial production of the process, poor product quality, and the like. It is convenient for large-scale industrial operation, high industrial application value, and the effect of improving separation effect

Active Publication Date: 2007-12-19
江苏美通制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The technical problem to be solved by the present invention is to overcome the problems of low content of medicinal ingredients in tripterygium wilfordii polyglycosides extracted by the extraction method of the prior art, poor product quality, or difficult large-scale industrial production of t...

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  • Tripterygium glycosides extract and its extraction process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The xylem of Tripterygium wilfordii is selected and processed into small pieces, and then crushed into powder by a pulverizer. Weigh 150Kg of powder, put it in a multi-purpose extraction pot, stir it evenly with 5 times the weight of water, heat it to 80°C-100°C with direct steam in the extraction pot, cook for 1 hour, cool to room temperature, and collect the filtrate. Add 6 times the weight of ethanol, soak for 8 hours, and the temperature is 30°C, release the ethanol extract, add ethanol again in the same way, soak once, and combine the extract.

[0039]Pump the extract to the distillation pot, first open the water inlet valves of the condenser and the cooler, and then slowly release the cooling water in the reaction pot, control the flow of steam and the temperature in the pot at about 70-100°C until the medicinal liquid The concentration of ethanol is less than 20% by volume.

[0040] Add chloroform equal to the volume of the concentrated solution to reflux and ex...

Embodiment 2

[0047] The xylem of Tripterygium wilfordii is selected and processed into small pieces, and then crushed into powder by a pulverizer. Weigh 150Kg of powder, put it in a multi-purpose extraction pot, stir it evenly with 3 times the weight of water, heat it to 50°C-60°C with direct steam in the extraction pot, cook for 40 minutes, cool to room temperature, and collect the filtrate. Repeat the water extraction 2 times. Add 10 times the weight of 90% methanol aqueous solution (volume percentage), soak for 24 hours at a temperature of 20° C., and release the methanol extract. Combine the extracts.

[0048] Pump the extract to the distillation pot, first open the water inlet valves of the condenser and the cooler, and then slowly release the cooling water in the reaction pot, control the flow of steam and the temperature in the pot at about 70-100°C until the medicinal liquid The concentration of methanol is less than 10% by volume.

[0049] Add 3 times the volume of the concentr...

Embodiment 3

[0055] The xylem of Tripterygium wilfordii is selected and processed into small pieces, and then crushed into powder by a pulverizer. Weigh 150Kg of powder, put it in a multi-purpose extraction pot, stir evenly with 10 times the weight of water, heat directly to 95°C-100°C in the extraction pot, cook for 30 minutes, cool to room temperature, and collect the filtrate. Repeat the water extraction 1 time. Add 6 times the weight of 40% isopropanol aqueous solution (volume percentage), soak for 15 hours, the temperature is 50°C, release the isopropanol extract, repeat the extraction twice more, and combine the extracts.

[0056] Pump the extract to the distillation pot, first open the water inlet valves of the condenser and the cooler, and then slowly release the cooling water in the reaction pot, control the flow of steam and the temperature in the pot at about 70-100°C until the medicinal liquid The concentration of isopropanol is less than 5% by volume.

[0057] Add cyclohexan...

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Abstract

The process of extracting tripterygium glycosides includes the following steps: 1. extracting coarse tripterygium glycosides product through water extracting tripterygium powder, extracting with alcohol or alcohol aqua, merging the extracted solution, concentrating to volume content of alcohol not more than 20 %, organic solvent extracting and concentrating to obtain dry coarse tripterygium glycosides product; and 2. refining through dissolving the coarse product in organic solvent, adsorbing with adsorbent, filtering, eluting the filter cake, concentrating the eluted liquid, column chromatographic separation, eluting with organic solvent, and concentrating the eluted liquid to obtain dry product. The process has simple operation, low cost, short production period, less environmental pollution, and easy application in industrial production, and the product has high effective component content and high pharmaceutical effect.

Description

technical field [0001] The invention relates to a plant extract and an extracting method thereof, in particular to a tripterygium glycoside extract and an extracting method thereof. Background technique [0002] Tripterygium genus is mainly distributed in the mountainous area south of the Yangtze River Basin and Changbai Mountain in northeast China in my country. It is widely spread among the people as herbal medicine for treating arthritis, bruises, skin diseases, etc., and is also used as pesticide. Clinically, domestic research on Tripterygium wilfordii has achieved remarkable results and breakthroughs. It has developed from the treatment of rheumatoid arthritis to the treatment of lupus erythematosus, psoriasis, nephritis and tumor research and other common diseases and difficult miscellaneous diseases. Due to its It has a wide range of applications, remarkable curative effect, and has a unique therapeutic effect on difficult and persistent diseases, so it has gradually ...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61P13/12
Inventor 林健
Owner 江苏美通制药有限公司
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