Inhibitors of copper-containing amine oxidases

A technology of amine oxidase and compounds, applied in the field of enzyme inhibitors, can solve problems such as not showing activity
CN1450998AInactive Publication Date: 2003-10-22BIOTIE THERAPIES LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BIOTIE THERAPIES LTD
Publication Date
2003-10-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to hydrazino compounds that functions as inhibitors of copper-containing amine oxidases commonly known as semicarbazidesensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatorses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The compounds have general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R<1> to R<8> and X are as defined herein.
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Description

field of invention

[0001] The invention belongs to the field of medicinal chemistry, and relates to a hydrazine-based compound and its use as an inhibitor of copper-containing amine oxidase (E.C. 1.4.3.6) and enzymes apparently equivalent thereto. The compounds of the present invention have medical applications, such as the treatment of various diseases including but not limited to various inflammations. In particular, these compounds can be used to treat acute and chronic inflammatory conditions or diseases, such as chronic arthritis, enteritis and chronic skin diseases, as well as diseases related to carbohydrate metabolism and aberrations in adipocyte differentiation or function and smooth muscle cell function related diseases. Background of the invention

[0002] VAP-1 is a human endothelial cell adhesion molecule, which has a variety of unique properties different from other inflammation-related adhesion molecules. This molecule has a specific and constrained expressi...

Claims

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