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Composition with anti-gout effect and preparation method and application thereof

A composition and anti-gout technology, applied in the field of natural active products, to achieve the effect of small side effects and high safety

Inactive Publication Date: 2017-02-22
长春圣健医药制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, non-selective non-steroidal anti-inflammatory drugs such as indomethacin are often accompanied by adverse reactions such as gastrointestinal symptoms, and usually require the addition of gastric protective agents when used, and are contraindicated for patients with active peptic ulcers. Renal insufficiency should be used with caution

Method used

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  • Composition with anti-gout effect and preparation method and application thereof
  • Composition with anti-gout effect and preparation method and application thereof
  • Composition with anti-gout effect and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A composition with anti-gout effect, prepared by the following method:

[0029] 1. Prepare raw materials.

[0030] Mix amaranth, frankincense, myrrh, and dried safflower in equal proportions, weigh 200g, crush, and set aside.

[0031] Two, extraction.

[0032] Take the above raw materials, place them in a round bottom flask, add 10ml of ethanol aqueous solution per gram of raw materials (that is, the ratio of solid to liquid is 1:10), add 2000ml of ethanol aqueous solution with a volume percentage of 95%, reflux extraction for 2h, repeat Three times, filtered, combined extracts, concentrated under reduced pressure to extract.

[0033] Three, extraction.

[0034] Take the above extract, disperse it into 200ml of water to obtain the mother liquor, extract three times with 200ml of petroleum ether (the volume ratio of the mother liquor to petroleum ether is 1:1), and 200ml of ethyl acetate (the volume ratio of the mother liquor to ethyl acetate is 1:1) (200ml each time...

experiment example 1

[0042] The extracts prepared by the above-mentioned examples and comparative examples were carried out in the mouse ear swelling experiment, the specific method is as follows:

[0043] 1. Method.

[0044] Take Kunming mice with a body weight of 18-22g, male, and randomly group them into positive group (give Voltaren, i.e. diclofenac diethylamine emulsion), blank group (give normal saline), extract group, 10 mice in each group mice.

[0045] Among them, the blank group was smeared with normal saline on the left ear, the positive group was given Voltaren (diclofenac diethylamine emulsion) 0.5ml in the left ear, and the extract group was smeared with the test drug (extract) in the left ear, 1 time / h. Medicine 5 times. One hour after the last administration, xylene was applied to the left ear of the mice, and the mice were sacrificed 20 minutes later. The ears were punched out, weighed, and the ear swelling degree and swelling inhibition rate were calculated.

[0046] 2. Result...

experiment example 2

[0058] The extracts prepared by the above-mentioned examples and comparative examples were subjected to the mouse writhing reaction experiment, and the specific method was as follows:

[0059] 1. Method.

[0060] Animal grouping and administration methods were the same as above. Administration 1 time / h, continuous administration 3 times. Remove the drug 1 hour after the last administration, and wipe the administration site with water. Then the mice were intraperitoneally injected with acetic acid solution (prepared before use), at a dose of 0.1mL / 10g. In a quiet environment, the number of times the mice writhed within 20 minutes after the intraperitoneal injection was recorded, and the pain suppression rate was calculated.

[0061] 2. Results.

[0062] Pain suppression rate was calculated according to the following formula:

[0063]

[0064] The specific results are shown in the table below:

[0065] Table 2 Pain suppression results in mice

[0066]

[0067]

[...

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Abstract

The invention relates to a composition with an anti-gout effect and a preparation method and application thereof, and belongs to the technical field of natural active products. The active ingredient of the composition is prepared from, by weight, 1-2 parts of edible amaranth, 1-2 parts of frankincense, 1-2 parts of myrrh and 1-2 parts of safflower. According to the composition, edible amaranth has the effects of easing and relieving pain, achieving astringing, clearing away heat and toxic materials and dispelling wind-evil, frankincense has the effect of promoting blood circulation to arrest pain, myrrh has the effect of dispersing blood stasis to arrest pain, frankincense and myrrh both can achieve the effects of eliminating swelling and promoting granulation when externally used, safflower has the effects of activating blood circulation, moistening dryness, relieving pain, eliminating swelling and promoting menstruation, therefore, the raw materials jointly achieve the synergistic effect, and the very good anti-gout effect is achieved; in addition, the composition is prepared by taking natural Chinese herbs as the raw materials, has the advantages of having few side effects and being high in safety and can be widely applied to treatment of gout, especially acute gouty arthritis.

Description

technical field [0001] The invention relates to the technical field of natural active products, in particular to a composition with an anti-gout effect, a preparation method and application thereof. Background technique [0002] Gout is a crystal-associated arthropathy caused by the deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by purine metabolic disorders and / or decreased uric acid excretion, especially acute characteristic arthritis and Chronic tophi diseases mainly include acute onset arthritis, tophi formation, tophi chronic arthritis, urate nephropathy and uric acid urolithiasis. [0003] For acute gouty arthritis, non-steroidal anti-inflammatory drugs are usually used to relieve the symptoms of acute gout, which is the first-line drug for acute gouty arthritis. However, non-selective non-steroidal anti-inflammatory drugs such as indomethacin are often accompanied by adverse reactions such as gastrointestinal symptoms, and usu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/328A61P19/06
CPCA61K36/21A61K36/286A61K36/324A61K36/328A61K2236/333A61K2236/55A61K2300/00
Inventor 王曼力杜培革安丽萍迟仁智
Owner 长春圣健医药制品有限公司
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