Litsea cubeba essential oil oral spray and preparation method thereof

Abstract

The invention discloses a litsea cubeba essential oil oral spray and a preparation method, and relates to the technical field of oral sprays.The litsea cubeba essential oil oral spray is characterized by being prepared from, by mass volume, 1-2% of litsea cubeba essential oil, 7.5-12.5% of xylitol, 2-3% of Tween-80, 0.3% of ethylparaben and the balance water. The prepared oral spray is clear and transparent in appearance, fresh and fragrant in smell, mild and comfortable in taste, capable of effectively caring oral health and wide in market prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of oral sprays, and more specifically, it relates to a litsea cubeba essential oil oral spray and a preparation method thereof. Background Art

[0002] Litsea cubeba has clear effects of freshening the body, gargling, and improving bad breath in the records of past herbal classics. Modern pharmacological research shows that litsea cubeba essential oil has clear antibacterial activity and can be used as a raw material for developing breath fresheners, and carry out the development, design, promotion and use of related products. Oral diseases have become a major public health problem due to their high prevalence and incidence, seriously affecting people's social interaction and mental health. Therefore, it is particularly important to develop safe and effective oral care products. However, with the changes in the addition amounts of litsea cubeba essential oil, xylitol, and Tween-80, the odor, taste, and appearance of the product will change. The main manifestations are as follows: the increase in the addition amount of litsea cubeba oil is accompanied by a decline in the taste and appearance scores, because the increase in the addition amount of litsea cubeba oil is likely to cause a bitter taste; the change in the addition amount of xylitol affects the taste; the change in the addition amount of Tween-80 affects the appearance of the spray. In view of this, the present invention provides a litsea cubeba essential oil oral spray and a preparation method thereof. Summary of the Invention

[0003] The purpose of the present invention is to provide a litsea cubeba essential oil oral spray and a preparation method thereof to solve the above problems.

[0004] The above technical purpose of the present invention is achieved through the following technical solutions:

[0005] The first aspect of the present invention provides a litsea cubeba essential oil oral spray, which is composed of the following components in mass-volume percentage: 1-2% of litsea cubeba essential oil, 7.5-12.5% of xylitol, 2-3% of Tween-80, 0.3% of ethylparaben, and the balance is water.

[0006] In combination with the first aspect, the present invention is further set as: 1% of litsea cubeba essential oil, 7.5% of xylitol, 2.5% of Tween-80, 0.3% of ethylparaben, and the balance is water.

[0007] A method for preparing the above-mentioned litsea cubeba essential oil oral spray includes the following steps:

[0008] S1. Weigh xylitol and ethylparaben in proportion, mix them, add water, and dissolve them by heating in a water bath.

[0009] S2. Add litsea cubeba essential oil, stir well, add Tween-80, and stir well.

[0010] S3. Slowly add the solution obtained in step S2 to the remaining water, stir while adding, make up the volume and mix well to obtain the litsea cubeba spray.

[0011] In combination with the second aspect, the present invention is further configured such that: in step S1, the temperature of the water bath heating is 50 - 70 °C.

[0012] In combination with the second aspect, the present invention is further configured such that: in step S1, the mass - volume ratio of xylitol, ethylparaben and water is 39:100 g / ml.

[0013] In combination with the second aspect, the present invention is further configured such that: in step S3, the fixed - volume capacity is 500 ml.

[0014] In summary, the present invention has the following beneficial effects: The oral spray prepared by the present invention optimizes the preparation formula of the litsea cubeba oral spray by studying three factors: the addition amount of litsea cubeba oil, the addition amount of xylitol, and the addition amount of Tween - 80. Through experiments, the optimal formula of the litsea cubeba oral spray is obtained, that is, the addition amount of litsea cubeba oil is 1.0%, the addition amount of xylitol is 7.5%, and the addition amount of Tween - 80 is 2.5%. The prepared oral spray has a clear and transparent appearance, a fresh and fragrant smell, a mild and comfortable taste, can effectively protect oral health, and has a broad market prospect. At the same time, as a new application product of litsea cubeba oil, this oral spray opens up a new path for the in - depth research and diversified application of litsea cubeba oil and provides a valuable basis. Description of the Drawings

[0015] Figure 1 It is a flow chart of a method for preparing a litsea cubeba essential oil oral spray in an embodiment of the present invention. Detailed Embodiments

[0016] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0017] Experimental Materials

[0018] Litsea cubeba essential oil (self - made in the laboratory, batch number 20241025); xylitol (batch number 20240920, Shanghai Zhanyun Chemical Co., Ltd.); Tween - 80 (batch number 20250121, Beijing Qingyuan Food Additive Co., Ltd.); ethylparaben (batch number 20250116, Zhejiang Tianhe Food Biology Co., Ltd.); Wahaha drinking pure water (batch number 202410282223JW, Hangzhou Wahaha Group Co., Ltd.)

[0019] Instruments and Equipment

[0020] Electronic analytical balance (model CEB1055N, Shanghai Lichen Bangxi Instrument Technology Co., Ltd.); Electronic balance (model CN-LQC50002, Kunshan Ant Measuring Equipment Co., Ltd.); Digital display constant temperature water bath (model HH-4, Shanghai Lichen Bangxi Instrument Technology Co., Ltd.)

[0021] The following experiments were evaluated according to Table 1.

[0022] Table 1 Evaluation Table of the Characteristics of Litsea cubeba Oral Spray

[0023]

[0024] Example 1:

[0025] A preparation method of litsea cubeba essential oil oral spray, comprising the following steps:

[0026] S1. Weigh 37.5 g of xylitol and 1.5 g of ethylparaben in proportion, mix them, add 100 ml of water, and heat in a water bath at 60 °C until dissolved;

[0027] S2. Add 5 g of litsea cubeba essential oil, stir well, add 10 g of Tween-80, and stir well;

[0028] S3. Slowly add the solution obtained in step S2 to the remaining water, stir while adding, make up to 500 mL and mix well to obtain litsea cubeba spray.

[0029] Among them, the preparation method of litsea cubeba essential oil is to place the dried litsea cubeba fruits in a pulverizer for pulverization, and perform steam explosion pretreatment, and then extract litsea cubeba essential oil by steam distillation method. The extraction rate of the obtained litsea cubeba essential oil is 6.8%.

[0030] Experimental Example 1: Effect of the Addition Amount of Litsea Cubeba Essential Oil on the Characteristics of the Spray

[0031] Weigh a certain amount of litsea cubeba essential oil, and prepare litsea cubeba sprays with contents of 1.0%, 1.5%, 2.0%, 2.5%, and 3.0% respectively according to the preparation method of Example 1, wherein the addition amount of Tween-80 is 2%, the addition amount of xylitol is 7.5%, and the addition amount of ethylparaben is 0.3%, and conduct detection and scoring.

[0032] As shown in Table 2, the increase in the addition amount of litsea cubeba oil is accompanied by a decline in the taste and appearance scores. The reason is that the increase in the addition amount of litsea cubeba oil is likely to cause a bitter taste. The total score is the highest when the addition amount of litsea cubeba oil is 1.0%. Originally, the addition amount of litsea cubeba oil less than 1.0% should be added as a reference. However, considering that the addition amount of litsea cubeba oil is related to its breath freshening effect, in order to avoid poor effects, the three levels of 1.0%, 1.5%, and 2.0% are selected for the orthogonal experiment.

[0033] Table 2 Influence of Litsea cubeba oil addition on spray quality

[0034] Addition amount of Litsea cubeba oil / % Appearance (30 points) Odor (30 points) Taste (40 points) Overall evaluation (100 points) 1.0 25 25 32 82 1.5 20 25 19 64 2.0 16 25 13.5 54.5 2.5 12 25 5 42 3.0 10 25 3 38

[0035] Experimental Example 2: Influence of xylitol addition on the characteristics of the spray

[0036] Weigh a certain amount of xylitol and prepare Litsea cubeba sprays with contents of 2.5%, 5.0%, 7.5%, 10.0%, and 12.5% respectively according to the preparation method of Example 1, where the addition amount of Litsea cubeba essential oil is 1.0%, the addition amount of Tween-80 is 2.0%, and the addition amount of ethyl paraben is 0.3%, and conduct detection and scoring.

[0037] As shown in Table 3, the change in the addition amount of xylitol has little effect on the spray appearance and smell. Its influence is mainly on the taste. Although the sprays at the addition amounts of 2.5% and 5.0% have a good taste, the sweetness is low, and it is too sweet at 12.5%. Therefore, the three levels of 7.5%, 10.0%, and 12.5% are selected for the orthogonal experiment.

[0038] Table 3 Influence of xylitol addition on spray quality

[0039] Addition amount of xylitol / % Appearance (30 points) Odor (30 points) Taste (40 points) Overall evaluation (100 points) 2.5 27 25 31 83 5.0 27 25 34 86 7.5 27 25 35 87 10.0 27 25 37 89 12.5 27 25 35 87

[0040] Experimental Example 3: Influence of Tween-80 addition on the characteristics of the spray

[0041] Weigh a certain amount of Tween-80 and prepare Litsea cubeba sprays with contents of 1.0%, 1.5%, 2.0%, 2.5%, and 3.0% respectively according to the preparation method of Example 1, where the addition amount of Litsea cubeba essential oil is 1.0%, the addition amount of xylitol is 7.5%, and the addition amount of ethyl paraben is 0.3%, and conduct detection and scoring.

[0042] As shown in Table 4, Tween-80 mainly affects the spray appearance and has little effect on the smell and taste. Perhaps due to the relatively small addition amount of Litsea cubeba oil, no oil separation phenomenon occurs. Therefore, according to the total score, the three levels of 2.0%, 2.5%, and 3% are selected for the orthogonal experiment.

[0043] Table 4 Influence of Tween-80 addition on spray quality

[0044]

[0045] Experimental Example 4: Orthogonal experiment on the preparation process of the spray

[0046] According to the results of the single-factor experiment, three factors that have a greater impact on the spray characteristics, namely the addition amount of Litsea cubeba essential oil, the addition amount of Tween-80, and the addition amount of xylitol, are selected for the orthogonal experiment and evaluated according to Table 1.

[0047] Table 5 Orthogonal Test Factor-Level Table of Litsea cubeba Oral Spray

[0048]

[0049] Table 6 Orthogonal Test Result Table of Litsea cubeba Oral Spray

[0050]

[0051] Based on the results of the above single-factor tests, an orthogonal test was carried out according to the orthogonal test factor-level table shown in Table 5, and the results of the orthogonal test are shown in Table 6. The optimal combination is A1 B1 C2, that is, the addition amount of litsea cubeba oil is 1.0%, the addition amount of xylitol is 7.5%, and the addition amount of Tween-80 is 2.5%. The oral spray prepared according to this combination is milky white in color, has a moderate sweetness, has an obvious cool taste of litsea cubeba oil and the unique fresh fragrance of litsea cubeba, and has no bitter or astringent taste.

[0052] In summary, for the preparation of the oral spray of the present invention, the optimization of the preparation formula of the litsea cubeba oral spray is studied through three factors: the addition amount of litsea cubeba oil, the addition amount of xylitol, and the addition amount of Tween-80. The optimal formula of the litsea cubeba oral spray is obtained through experiments, that is, the addition amount of litsea cubeba oil is 1.0%, the addition amount of xylitol is 7.5%, and the addition amount of Tween-80 is 2.5%. The oral spray prepared by the test has a clear and transparent appearance, a fresh and fragrant smell, a mild and comfortable taste, can effectively protect oral health, and has a broad market prospect. At the same time, as a new application product of litsea cubeba oil, the oral spray opens up a new path and provides valuable basis for the in-depth research and diversified application of litsea cubeba oil.

[0053] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A Litsea cubeba essential oil oral spray, characterized in that: It is composed of the following components by mass-volume percentage: 1-2% of Litsea cubeba essential oil, 7.5-12.5% of xylitol, 2-3% of Tween-80, 0.3% of ethyl paraben, and the balance is water.

2. The litsea cubeba essential oil oral spray according to claim 1, wherein: It is composed of the following components by mass-volume percentage: 1% of Litsea cubeba essential oil, 7.5% of xylitol, 2.5% of Tween-80, 0.3% of ethyl paraben, and the balance is water.

3. The preparation method of the Litsea cubeba essential oil oral spray according to any one of claims 1-2, characterized in that: It includes the following steps: S1. Weigh xylitol and ethyl paraben in proportion, mix them, add water, and dissolve them by heating in a water bath. S2. Add Litsea cubeba essential oil, stir well, add Tween-80, and stir well. S3. Slowly add the solution obtained in step S2 to the remaining water, stir while adding, make up the volume and mix well to obtain Litsea cubeba spray.

4. The preparation method of the Litsea cubeba essential oil oral spray according to claim 3, characterized in that: In step S1, the temperature of the water bath heating is 50-70 °C.

5. The preparation method of the Litsea cubeba essential oil oral spray according to claim 3, characterized in that: In step S1, the mass-volume ratio of xylitol and ethyl paraben to water is 39:100 g / ml.

6. The preparation method of the Litsea cubeba essential oil oral spray according to claim 3, characterized in that: In step S3, the volume made up is 500 ml.

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