NMN-containing circulation-promoting and skin aging-resisting repair patch and preparation method thereof

Abstract

The invention relates to the technical field of medical supplies, and particularly provides an NMN-containing circulation promoting and skin aging resisting repair patch which comprises a repair liquid and a non-woven fabric, the repairing liquid is prepared from the following raw materials in percentage by weight: 0.2 to 0.5 percent of sodium hyaluronate, 0.01 to 0.2 percent of beta-nicotinamide mononucleotide (NMN), 2 to 4 percent of glycerol, 0.5 to 1.5 percent of propylene glycol, 0.005 to 0.015 percent of ethylene diamine tetraacetic acid disodium salt, 0.015 to 0.03 percent of ethylparaben, 1 to 2 percent of sodium carboxymethyl cellulose, 0.05 to 2.0 percent of triethanolamine and the balance of purified water. The repair patch has good moisture retention, stability and oxygen permeability, and is small in irritation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical supplies, and in particular to a circulation-promoting and anti-skin aging repair patch containing NMN and a preparation method thereof. Background Art

[0002] Skin aging is an important aspect of the human body's natural aging process, manifested by problems such as sagging skin, increased wrinkles, and decreased elasticity. As we age, the skin's blood circulation gradually slows down and the cell metabolism capacity decreases, making it difficult for the skin to effectively absorb nutrients and repair itself. In addition, external environmental factors such as ultraviolet radiation, air pollution, and life stress can also accelerate the aging process of the skin. To address these problems, various anti-aging products have appeared on the market, but most products are limited to surface care and cannot deeply address the fundamental problems of poor skin circulation and accelerated aging.

[0003] In recent years, β-nicotinamide mononucleotide (NMN) has received widespread attention as an emerging anti-aging ingredient. NMN is a precursor of NAD+ (nicotinamide adenine dinucleotide) in the body, and NAD+ plays a vital role in cellular energy metabolism, DNA repair and anti-oxidation. Studies have shown that NMN has significant anti-aging effects, can help delay cell aging and promote skin repair.

[0004] However, it is still a technical challenge to effectively combine active ingredients and gel excipients and apply them to skin repair patches to simultaneously achieve the effects of promoting circulation, moisturizing, anti-aging and skin repair. In particular, how to ensure the stability of β-nicotinamide mononucleotide in the product and ensure the good moisturizing and oxygen permeability of the repair patch. Therefore, it is of great practical significance to develop a circulation-promoting and anti-skin aging repair patch containing NMN to meet consumers' demand for deep skin care.

[0005] A moisturizing hydrophilic gel containing NMN and a preparation method thereof are currently disclosed, wherein the gel matrix is ​​sodium alginate or poloxamer. However, sodium alginate relies on calcium ion cross-linking, and the gel formed therefrom has a single network structure, which is easily affected by changes in ionic strength. Poloxamer is a non-ionic block copolymer, and its viscosity fluctuates greatly with temperature, and it is easy to precipitate at high temperatures. Summary of the Invention

[0006] The purpose of the present invention is to provide a circulation-promoting, anti-skin aging repair patch containing NMN and a preparation method to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions: A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair liquid and a non-woven fabric connected in sequence from top to bottom, characterized in that the repair liquid is made of the following raw materials in weight percentage: 0.2-0.5% sodium hyaluronate, 0.01-0.2% β-nicotinamide mononucleotide (NMN), 2-4% glycerol, 0.5-1.5% propylene glycol, 0.005-0.015% disodium edetate, 0.015-0.03% ethylparaben, 1-2% sodium carboxymethylcellulose, 0.05-2.0% triethanolamine, and the balance is purified water.

[0008] The repair fluid, formulated with specific proportions to create a synergistic effect, not only provides excellent moisturizing properties but also effectively promotes blood circulation and enhances skin metabolism, thereby achieving anti-aging effects. In particular, the sodium hyaluronate: sodium carboxymethylcellulose ratio must be maintained within a certain range, while the amount and addition of glycerin ensure the stability of the gel's performance.

[0009] Preferably, the repair fluid is made from the following raw materials in weight percentage: 0.2% sodium hyaluronate, 0.01% β-nicotinamide mononucleotide (NMN), 4% glycerol, 1.5% propylene glycol, 0.008% disodium edetate, 0.03% ethylparaben, 2% sodium carboxymethylcellulose, 0.15% triethanolamine, and the balance is purified water.

[0010] Preferably, the repair fluid is made from the following raw materials in weight percentage: 0.3% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 3% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 1.75% sodium carboxymethylcellulose, 1.55% triethanolamine, and the balance is purified water.

[0011] Preferably, the repair fluid is made from the following raw materials in weight percentage: 0.5% sodium hyaluronate, 0.2% β-nicotinamide mononucleotide (NMN), 2% glycerol, 0.5% propylene glycol, 0.015% disodium edetate, 0.02% ethylparaben, 1.5% sodium carboxymethylcellulose, 1.0% triethanolamine, and the balance is purified water.

[0012] Preferably, the purified water is medical purified water with a maximum microbial limit of 100 cfu / ml.

[0013] A method for preparing the aforementioned NMN-containing circulation-promoting and anti-skin aging repair patch comprises the following steps: Weigh a certain amount of material and set aside; Add sodium hyaluronate and sodium carboxymethylcellulose to a container filled with purified water and stir. Once completely dissolved, add β-nicotinamide mononucleotide (NMN), glycerin, propylene glycol, disodium EDTA, and ethylparaben to the container. Mix and stir for 25-30 minutes, then let stand for 3-4 hours. Add triethanolamine to adjust the pH to 4-7 to form a gel. The gel is evenly coated on a non-woven fabric backing layer, placed in an aluminum foil bag, and sealed to produce a circulation-promoting and anti-skin aging repair patch containing NMN.

[0014] Technical effects and advantages of the present invention: Innovative formula combination: For the first time, this invention scientifically combines NMN with sodium hyaluronate as a matrix, sodium methylcellulose and glycerin as a moisturizer to form a synergistic complex, which not only improves the stability of NMN, but also enhances its moisturizing performance and breathability.

[0015] Multiple synergistic effects: The repair patch of the present invention uses NMN to increase the NAD+ level of skin cells, activates Sirtuins family proteins, and improves cell metabolism function; at the same time, sodium hyaluronate and glycerin synergistically moisturize and lock in moisture to improve dry skin; by promoting local microcirculation, it increases the skin's nutrient supply and improves skin aging conditions from multiple angles and in all directions.

[0016] Excellent stability and safety: By optimizing the formula ratio and pH value, and using medical-grade purified water, the stability of the product during storage and the safety during use are guaranteed, avoiding the problem of NMN being easily oxidized and degraded.

[0017] Comfortable use experience: By selecting appropriate backing layer and cover layer materials, and optimizing the viscosity and ductility of the repair fluid, the patch has good fit, breathability and comfort, making it suitable for long-term use.

[0018] Easy to use: The patch form is easy to use and can be applied to the face or other parts that need care at any time. It is especially suitable for skin care needs in modern fast-paced lifestyles.

[0019] The NMN in this invention increases the level of NAD+, promotes cellular energy metabolism and DNA repair, and fundamentally delays the aging process of the skin. At the same time, NMN works synergistically with sodium hyaluronate to significantly improve the elasticity and firmness of the skin, reduce the formation of wrinkles and fine lines, and repair damaged skin.

[0020] This invention uses a mild formula with strictly screened ingredients that do not contain irritants that are harmful to the skin. It is suitable for all skin types, including sensitive skin. The pH value of the product is controlled between 4 and 7, which matches the natural pH of the skin and reduces the risk of irritation during use. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the preparation process of a circulation-promoting and anti-skin aging repair patch containing NMN in the present invention; Figure 2 This is a schematic diagram of the intradermal induction injection area in an embodiment of the present invention. DETAILED DESCRIPTION

[0022] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention. Example 1

[0023] A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 0.2% sodium hyaluronate, 0.01% β-nicotinamide mononucleotide (NMN), 4% glycerol, 1.5% propylene glycol, 0.008% disodium edetate, 0.03% ethylparaben, 2% sodium carboxymethylcellulose, 0.15% triethanolamine, and the balance is purified water.

[0024] Purified water is medical purified water with a maximum microbial limit of 100 cfu / ml.

[0025] The preparation method of the circulation-promoting and anti-skin aging repair patch comprises the following steps: Weigh a certain amount of material and set aside; Add sodium hyaluronate and sodium carboxymethylcellulose to a container filled with purified water and stir. Once completely dissolved, add β-nicotinamide mononucleotide (NMN), glycerin, propylene glycol, disodium EDTA, and ethylparaben to the container. Mix and stir for 25-30 minutes, then let stand for 3-4 hours. Add triethanolamine to adjust the pH to 4-7 to form a gel. The gel is evenly coated on a non-woven fabric backing layer, placed in an aluminum foil bag, and sealed to produce a circulation-promoting and anti-skin aging repair patch containing NMN. Example 2

[0026] A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 0.3% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 3% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 1.75% sodium carboxymethylcellulose, 1.55% triethanolamine, and the balance is purified water.

[0027] The preparation method of the circulation-promoting and anti-skin aging repair patch is described with reference to Example 1. Example 3

[0028] A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 0.5% sodium hyaluronate, 0.2% β-nicotinamide mononucleotide (NMN), 2% glycerol, 0.5% propylene glycol, 0.015% disodium edetate, 0.02% ethylparaben, 1.5% sodium carboxymethylcellulose, 1.0% triethanolamine, and the balance is purified water.

[0029] The preparation method of the circulation-promoting and anti-skin aging repair patch is described with reference to Example 1.

[0030] Comparative Example 1 (Compared with Example 2, sodium alginate was used instead of sodium carboxymethyl cellulose) A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 0.3% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 3% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 2% sodium alginate, 1.55% triethanolamine, and the balance is purified water.

[0031] The preparation method of the circulation-promoting and anti-skin aging repair patch is described with reference to Example 1.

[0032] Comparative Example 2 (Compared with Example 2, carboxymethyl cellulose sodium was replaced with poloxamer) A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 0.3% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 3% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 2% poloxamer, 1.55% triethanolamine, and the balance is purified water.

[0033] The preparation method of the circulation-promoting and anti-skin aging repair patch is described with reference to Example 1.

[0034] Comparative Example 3 (Compared with Example 2, the content of sodium carboxymethyl cellulose was increased to 5%) A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 0.3% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 3% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 5% sodium carboxymethylcellulose, 1.55% triethanolamine, and the balance is purified water.

[0035] The preparation method of the circulation-promoting and anti-skin aging repair patch is described with reference to Example 1.

[0036] Comparative Example 4 (Compared with Example 2, the sodium hyaluronate content was increased to 1%) A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 1% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 3% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 1.75% sodium carboxymethylcellulose, 1.55% triethanolamine, and the balance is purified water.

[0037] The preparation method of the circulation-promoting and anti-skin aging repair patch is described with reference to Example 1.

[0038] Comparative Example 5 (Compared with Example 2, the glycerol content was increased to 5%) A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair fluid and a non-woven fabric connected in sequence from top to bottom. The repair fluid is made of the following raw materials in the following weight percentages: 0.5% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 5% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 1.75% sodium carboxymethylcellulose, 1.55% triethanolamine, and the balance is purified water.

[0039] The preparation method of the circulation-promoting and anti-skin aging repair patch is described with reference to Example 1.

[0040] In the formulas of the above three groups of examples, purified water is used as the solvent, sodium hyaluronate and sodium carboxymethylcellulose are used as the gel matrix, β-nicotinamide mononucleotide (NMN) is used as the main drug, glycerin is used as the moisturizer, disodium edetate is used as the chelating agent, ethylparaben is used as the preservative, and triethanolamine is used as the neutralizer.

[0041] The above three groups of embodiments can all produce a circulation-promoting and anti-skin aging repair patch containing NMN, among which the circulation-promoting and anti-skin aging repair patch containing NMN produced in the second group of embodiments has the best effect. The present invention proposes a circulation-promoting and anti-skin aging repair patch containing NMN. The NMN in the present invention promotes cellular energy metabolism and DNA repair by increasing the level of NAD+, thereby fundamentally delaying the aging process of the skin. At the same time, NMN works synergistically with sodium hyaluronate to significantly improve the elasticity and firmness of the skin, reduce the formation of wrinkles and fine lines, and repair damaged skin.

[0042] The advantages of this application are mainly reflected in: the specific ratio of sodium hyaluronate and sodium carboxymethylcellulose, the carboxylic acid group and hydroxyl group of sodium hyaluronate can bind a large number of water molecules to form a deep moisturizing film, and the linear structure of sodium carboxymethylcellulose can promote the uniform distribution of the network structure of sodium hyaluronate. The combination of the two constructs an elastic-viscous double network, which improves mechanical strength and water retention. Sodium hyaluronate has the characteristics of rapid film formation. Sodium carboxymethylcellulose fills the gaps, which significantly reduces the thickness of the film. Its porous network structure also allows oxygen to diffuse freely to avoid clogging of skin pores. However, the study also found that if the content of sodium carboxymethylcellulose in the gel is too high, it will not achieve a good effect. This is also the reason why the stability of sodium carboxymethylcellulose used in the prior art is not good. The gel film using sodium alginate in the prior art is thicker, which can easily cause acne on the skin, and the film is brittle and prone to debris. Poloxamer relies on physical thickening and has no active absorption capacity. Moisturizing depends on external moisture, which can easily lead to dry skin, loose film, and poor air permeability. From a safety perspective, poloxamer is a synthetic non-ionic surfactant that can easily cause contact dermatitis in allergic people, and some sources of sodium alginate can easily cause marine pollution.

[0043] At the same time, a specific amount of glycerin also has a significant synergistic effect on the rheology and stability of the gel matrix of this application, reducing water evaporation. The weak hydrogen bonds formed by glycerin and sodium hyaluronate can reduce the instantaneous viscosity under shear force, and the hydrogen bonds are restored after the shear ends, giving the gel a silky skin feel. Excessive use will not have the corresponding effect. It can lower the freezing point of the gel and inhibit the damage of water crystallization to the gel network at low temperatures.

[0044] 1. Gel performance test Oxygen permeability: Oxygen permeability tester (OTR method) is used to measure the ability of oxygen to penetrate the gel film under constant pressure and calculate the oxygen permeability (OTR, unit: cm³ / m 2 A uniform gel film was prepared; the gel film was placed in a test chamber, with high-purity oxygen and dry nitrogen (carrier gas) introduced into the chamber from both sides. A sensor was used to detect changes in the oxygen concentration in the nitrogen and calculate the oxygen permeability.

[0045] Moisturizing performance: Weigh 2 g of the prepared gel composition and place it in a desiccator with an adsorbent such as silica gel. Weigh the sample after 72 hours. Moisturizing rate = sample mass after a specific period of time / sample mass before placement × 100%.

[0046] Stability: Accelerated aging test, which accelerates degradation under conditions such as high temperature, high humidity, and light to predict long-term stability.

[0047] Conditions: Temperature: 40°C; Humidity: 75% RH (to accelerate hydrolysis); Illumination: Xenon lamp simulated sunlight (irradiance 0.35 W / m²). After 30 days, observe changes in gel properties and determine active ingredient content (calculated based on day 0 as 100%).

[0048] Table 1 Gel performance test results

[0049] The experimental results show that the sodium carboxymethyl cellulose and sodium hyaluronate used in this application are combined in a specific ratio and used in appropriate amounts to optimize gel performance. The oxygen permeability of the gels prepared in Comparative Examples 1-2, when the gel matrix is ​​varied, differs significantly from that of the examples, and the gel appearance undergoes some changes in the accelerated test. Furthermore, when the sodium carboxymethyl cellulose content in the gel of Comparative Example 3 is increased to 5%, the oxygen permeability of the gel deteriorates significantly due to the filling of the network voids. While good oxygen permeability demonstrates the comfort of the gel of this application after application to the skin, an overly dense gel structure can easily lead to adverse reactions such as skin allergies. Furthermore, active ingredient content determination demonstrates good active ingredient retention, demonstrating a balance between effectiveness and comfort. Comparative Examples 4-5, in which excessive amounts of sodium hyaluronate and glycerin are used, exhibit comparable moisturizing properties and no significant change in appearance, but exhibit a slight decrease in oxygen permeability and accelerated stability, reflecting a significant decrease in active ingredient content. In Comparative Example 3, the excessively high content of sodium carboxymethyl cellulose also resulted in a significant decrease in the NMN content in the accelerated test. It is speculated that sodium carboxymethyl cellulose itself is weakly alkaline, and NMN is easily hydrolyzed under high concentration conditions in the local microenvironment. At the same time, high concentrations limit the uniformity of oxygen diffusion, resulting in accelerated local reactions and affecting the stability of the active ingredient. The high local viscoelasticity of high-concentration sodium hyaluronate will lead to local high-humidity areas, and excessive sodium hyaluronate and glycerol will excessively consume chelating agents, all of which may induce accelerated NMN degradation. It can be seen from the above experiments that in the selection of gel components in this application, not only the type but also its content has an important influence on the gel performance, which fully reflects the specificity of the selection of specific components in this application.

[0050] 2. In vitro cytotoxicity test - extract method: 2.1 Purpose The purpose of this test is to evaluate whether the test sample extract has cytotoxic effect on L-929 cells.

[0051] 2.2 Test information Sample of this application: The gel of Example 2 was used as the sample for measurement Blank control: MEM medium containing 10% fetal bovine serum.

[0052] Negative control: High Density Polyethylene Film.

[0053] Positive control: 6.4% phenol solution.

[0054] Main instruments: CO2 incubator, constant temperature shaking incubator, clean workbench, cell counter, inverted microscope, portable pH meter.

[0055] Main reagents: fetal bovine serum (FBS), MEM medium, penicillin and streptomycin, and trypsin.

[0056] This experiment used L-929 cells.

[0057] 2.3 Experimental design The preparation of the extract is shown in Table 2.

[0058] Table 2 Extraction process

[0059] 1) Extraction was performed under dynamic conditions. 2) The final extract was used for testing immediately.

[0060] 2.4 Experimental process (1) L-929 cells were cultured in MEM medium containing 10% fetal bovine serum and antibiotics (penicillin 100 U / mL, streptomycin 100 µg / mL) in an incubator (37°C, 5% CO2). The cells were digested with 0.25% trypsin (containing EDTA) to prepare a single-cell suspension. The cell suspension was centrifuged (200 g, 5 min), and then the cells were redispersed in culture medium to adjust the cell density to 1×105 cells / mL. The cell suspension was inoculated into a 6-well culture plate with 2 mL per well, and the plate was incubated in an incubator (5% CO2, 37°C) for 24 h.

[0061] (2) After the cells have grown into a monolayer, discard the original culture medium and add 2 mL of the test sample extract (100%), blank control solution, positive control (100%), and negative control solution (100%), respectively. Culture in an incubator (5% CO2, 37°C) for 24 h. Perform three replicates for each group.

[0062] (3) After 24 h of culture, observe the cell morphology.

[0063] 2.5 Evaluation Criteria The degree of cytotoxicity is expressed by reaction grade, see Table 3.

[0064] Table 3 Cytotoxicity grading

[0065] Grades greater than 2 were considered to be cytotoxic.

[0066] 2.6 Test results The cell morphology results are shown in Table 4.

[0067] Table 4 Cell morphology observation

[0068] 2.7 Conclusion Under the conditions of this experiment, the sample extract showed no cytotoxic effect on L-929 cells, indicating that the gel of the present application has no obvious side effects on normal cells.

[0069] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A circulation-promoting and anti-skin aging repair patch containing NMN, comprising a repair liquid and a non-woven fabric connected in sequence from top to bottom, characterized in that: The repair fluid is prepared from the following raw materials in weight percentage: 0.05-0.5% sodium hyaluronate, 0.01-0.2% β-nicotinamide mononucleotide (NMN), 2-4% glycerol, 0.5-1.5% propylene glycol, 0.005-0.015% disodium edetate, 0.015-0.03% ethylparaben, 1-2% sodium carboxymethylcellulose, 0.05-2.0% triethanolamine, and the balance is purified water.

2. A circulation-promoting and anti-skin aging repair patch containing NMN according to claim 1, characterized in that: The repair fluid is prepared from the following raw materials in percentage by weight: 0.1% sodium hyaluronate, 0.01% β-nicotinamide mononucleotide (NMN), 4% glycerol, 1.5% propylene glycol, 0.008% disodium edetate, 0.03% ethylparaben, 2% sodium carboxymethylcellulose, 0.15% triethanolamine, and the balance is purified water.

3. A circulation-promoting and anti-skin aging repair patch containing NMN according to claim 1, characterized in that: The repair fluid is prepared from the following raw materials in percentage by weight: 0.05% sodium hyaluronate, 0.1% β-nicotinamide mononucleotide (NMN), 3% glycerol, 1% propylene glycol, 0.01% disodium edetate, 0.02% ethylparaben, 1.75% sodium carboxymethylcellulose, 1.55% triethanolamine, and the balance is purified water.

4. A circulation-promoting and anti-skin aging repair patch containing NMN according to claim 1, characterized in that: The repair fluid is prepared from the following raw materials in percentage by weight: 0.3% sodium hyaluronate, 0.2% β-nicotinamide mononucleotide (NMN), 2% glycerol, 0.5% propylene glycol, 0.015% disodium edetate, 0.02% ethylparaben, 1.5% sodium carboxymethylcellulose, 1.0% triethanolamine, and the balance is purified water.

5. The circulation-promoting and anti-skin aging repair patch containing NMN according to claim 1, characterized in that: The purified water is medical purified water with a maximum microbial limit of 100 cfu / ml.

6. A method for preparing a circulation-promoting and anti-skin aging repair patch containing NMN according to any one of claims 1 to 5, characterized in that: The following steps are involved: Weigh a certain amount of material and set aside; Add sodium hyaluronate and sodium carboxymethylcellulose to a container filled with purified water and stir. Once completely dissolved, add β-nicotinamide mononucleotide (NMN), glycerin, propylene glycol, disodium EDTA, and ethylparaben to the container. Mix and stir for 25-30 minutes, then let stand for 3-4 hours. Add triethanolamine to adjust the pH to 4-7 to form a gel. The gel is evenly coated on a non-woven fabric backing layer, placed in an aluminum foil bag, and sealed to produce a circulation-promoting and anti-skin aging repair patch containing NMN.

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