A crisaborole sustained-release film having good sustained release effects and a preparing method thereof
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A technology of criborole and slow-release film, which is applied in the field of biomedical materials, can solve the problems of not being able to keep it for a long time and being easy to be wiped, and achieve a good slow-release therapeutic effect
Inactive Publication Date: 2018-12-07
苏州尚宜佳生物科技有限公司
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Problems solved by technology
At present, most of the crisborole preparations are ointments, which do not involve sustained release, need fixed-point administration, and are easy to be wiped off, so they cannot be kept for a long time
Method used
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Embodiment 1
[0025] A. Preparation of the first layer of slow-release film: Mix crisborole 20%, glycerin 25%, microcrystalline cellulose 25%, propylene glycol 7%, carrageenan 8%, and polyvinylpyrrolidone 15%, fully mix, melt, and extrude Extrude the film-forming agent from the machine;
[0026] B, preparation of the second layer of delayed-release film: 20% of crisborole, 25% of propylene alcohol, 25% of sorbitol, 7% of polysorbate, 8% of guar gum, and 15% of polycarbophil are mixed fully, Add an appropriate amount of water to dissolve, stir evenly, and spread it evenly on the above slow-release film, and dry it in a dryer until there is no obvious moisture, and the drying temperature is 60°C;
[0027] C. Cut and get.
Embodiment 2
[0029] A. Preparation of the first layer of slow-release film: mix crisborole 25%, polyethylene glycol 23%, modified starch 22%, menthol 8%, carboxymethylcellulose sodium 7%, chitosan 15% Full, melted, extruded film-forming agent with extruder;
[0030] B. Preparation of the second delayed-release film: mix crisborole 25%, triacetin 23%, dextrin 22%, menthol 8%, carboxymethylcellulose sodium 7%, polyvinyl alcohol 15% fully, add an appropriate amount of water to dissolve, stir evenly, and spread it evenly on the above slow-release film, and dry it in a dryer until there is no obvious moisture, and the drying temperature is 60°C;
[0031] C. Cut and get.
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Abstract
A crisaborole sustained-release film having good sustained release effects and a preparing method thereof are disclosed. The film is prepared from an active component, a plasticizer, a filler, an absorption promoter, a suspending aid and an adhesive. The film can overcome a problem that medicine use frequency is over-high and can provide longer skin residence time and a decreased number of times of administration. A plurality of film forming auxiliary materials, which supplement each other and which are integral, are adopted to prepare the film, the plasticizer and the filler enhance film forming performance, the absorption promoter enhances medicine infiltration capacity, the suspending aid ensures dispersibility of raw materials in a liquid state, and the adhesive enhances the degree ofadhesion between the film and skin.
Description
technical field [0001] The invention relates to a crisborole sustained-release film with good sustained-release effect and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Crisaborole, an inhibitor of phosphodiesterase 4 (PDE4), which results in increased intracellular levels of cyclic adenosine monophosphate (cAMP), is used in the treatment of fungal infections, more specifically Onychomycosis and / or fungal skin infections. The drug was approved for marketing by the U.S. Food and Drug Administration (FDA) in December 2016. It was developed by Anacor Pharmaceuticals and is responsible for marketing in the United States. The trade name is Crisaborole and its chemical name is 5-(4-cyanophenoxy )-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, the English name is 4-((1-hydroxy-1,3-dihydrobenzo[c][1, 2] oxaborol-5-yl)oxy)benzonitrile, the chemical structural formula is as shown in formula (I): [0003] [0004] The charac...
Claims
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Application Information
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