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Compound pharmaceutical composition for treating inflammatory diseases of skin

A technology of skin inflammation and composition, applied in the field of compound pharmaceutical composition for treating skin inflammatory diseases

Active Publication Date: 2018-12-14
HEFEI IND PHARMA INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, at present, the above-mentioned drugs have certain defects in clinical use, and it is still of great application value to find or develop new therapeutic drugs with better efficacy.

Method used

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  • Compound pharmaceutical composition for treating inflammatory diseases of skin
  • Compound pharmaceutical composition for treating inflammatory diseases of skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Ointment, prescribed as follows:

[0041] components

[0042] Take the prescribed amount of criborole and tofacitinib, dissolve or disperse in the mixed solution of propylene glycol and glycerin with a total amount of 27.98%, and after they are uniformly dispersed, add an appropriate amount of antioxidant, mix well and set aside; another Take the total amount of 70% white vaseline and glyceryl monostearate and place them in a stainless steel tank, heat them, melt them at 65°C ± 5°C, keep the temperature, and slowly mix the above mixed solution with a stirrer / homogenizer Slowly add to the molten base, mix for a period of time, remove the heat source, continue to mix after cooling until completely uniform, and obtain an ointment.

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to compound pharmaceutical composition for treating inflammatory diseases of skin. The compound pharmaceutical composition is characterized in that active ingredients of the compound medicine comprise tofacitinib and crisaborole. The pharmaceutical composition has higher treatment effects and lower use dosage, has remarkablecollaborative treatment effects and can be used for treating inflammatory diseases of skin.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound pharmaceutical composition for treating skin inflammatory diseases. The pharmaceutical composition of the invention can be used for treating skin inflammation diseases. Background technique [0002] Inflammation is a common and important basic pathological process. Trauma infection on the body surface and most common and frequently-occurring diseases of various organs belong to inflammatory diseases[Cruz-Migoni S, J.Fat-Associated LymphoidClusters in Inflammation and Immunity[J].Front Immunol.2016,7:612]. Skin inflammatory diseases include a variety of conditions characterized by skin inflammation and itching, such as atopic dermatitis, eczema, psoriasis, contact dermatitis, allergic dermatitis, seborrheic dermatitis, contact dermatitis, systemic lupus erythematosus Wait. [0003] Inflammation and pruritus are two important features of skin inflammatory diseases. ...

Claims

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Application Information

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IPC IPC(8): A61K31/69A61K31/519A61P29/00A61P17/00A61P17/06A61P17/08
CPCA61P17/00A61P17/06A61P17/08A61P29/00A61K31/519A61K31/69A61K2300/00A61P43/00A61K47/10A61K9/06A61K9/0014
Inventor 何广卫储昭兴许勤龙莫佳佳赵炎卞林翠谷元凤邵莉
Owner HEFEI IND PHARMA INST
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