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Crisaborole temperature-sensitive gel as well as preparation method and application thereof

The technology of a temperature-sensitive gel and criborole, applied in the field of medicine, can solve the problems of skin pigmentation, easy recurrence, difficult clinical treatment, etc., and achieve the effect of preventing drug extravasation and achieving sustained release effect.

Inactive Publication Date: 2018-08-28
苏州尚宜佳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disease is lingering and difficult to heal, and the clinical treatment is difficult, which has a great impact on the physical and mental health of patients
[0003] At present, Western medicine is mainly based on symptomatic treatment such as antihistamine drugs, glucocorticoid drugs, and astringent and protective drug preparations. Although these drugs can control symptoms, they are prone to relapse after drug withdrawal, and long-term, repeated, large-scale Area use can cause adverse reactions such as local telangiectasia and skin pigmentation

Method used

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  • Crisaborole temperature-sensitive gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This example provides a crisborole thermosensitive gel, which is actually prepared by the following method:

[0029] (1) Take 17g of Poloxamer 407, 3g of Poloxamer 188, and 0.5g of hydroxypropyl cellulose, evenly spread on the surface of 40g of purified water, let it stand for 24 hours, stir it well and put it in the refrigerator for complete dissolution and swelling as the first mixture;

[0030] (2) Stir and dissolve 2g crisborole, 10g propylene glycol and 10g ethanol mixture as the second mixture;

[0031] (3) Add the second mixture to the first mixture while stirring, and finally add purified water to 100 g, and stir well to obtain a thermosensitive gel for treating atopic dermatitis.

Embodiment 2

[0033] This example provides a crisborole thermosensitive gel, which is actually prepared by the following method:

[0034] (1) Take 17g of poloxamer 407, 3g of poloxamer 188, and 0.5g of methyl cellulose, spread evenly on the surface of 40g of purified water, let it stand for 24 hours, stir it well and put it in the refrigerator to refrigerate, completely dissolve and swell as the first mixture;

[0035] (2) Stir and dissolve 2g crisborole, 15g propylene glycol and 10g ethanol mixture as the second mixture;

[0036] (3) Add the second mixture to the first mixture while stirring, and finally add purified water to 100 g, and stir well to obtain a thermosensitive gel for treating atopic dermatitis.

Embodiment 3

[0038] This example provides a crisborole thermosensitive gel, which is actually prepared by the following method:

[0039] (1) Take 17g of poloxamer 407, 3g of poloxamer 188, and 0.5g of ethyl cellulose evenly spread on the surface of 40g of purified water, let it stand for 24 hours, stir it well and put it in the refrigerator to refrigerate, completely dissolve and swell as the first mixture;

[0040] (2) Stir and dissolve 2g crisborole, 10g propylene glycol and 10g ethanol mixture as the second mixture;

[0041] (3) Add the second mixture to the first mixture while stirring, and finally add purified water to 100 g, and stir well to obtain a thermosensitive gel for treating atopic dermatitis.

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PUM

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Abstract

The invention provides crisaborole temperature-sensitive gel as well as a preparation method and application thereof. The crisaborole temperature-sensitive gel is prepared from the following raw material components in percentage by mass: 1 to 2 percent of crisaborole, 17 to 23 percent of poloxamer, 0.1 to 1 percent of modified cellulose, 5 to 15 percent of propylene glycol and / or glycerol, 5 to 10percent of ethanol, 0.01 to 0.02 percent of butylated hydroxytoluene and the balance of water. The crisaborole temperature-sensitive gel disclosed by the invention has the advantages that injection implantation and long-term drug release can be achieved; the drug can play a good slow-release effect in a human body by adopting a percutaneous drug delivery mode; in addition, drug extravasation canbe prevented and long-term drug release is achieved.

Description

technical field [0001] The invention relates to a crisborole temperature-sensitive gel and a preparation method and application thereof, belonging to the technical field of medicine. Background technique [0002] Eczema is an allergic inflammatory skin disease caused by a variety of internal and external factors. It is characterized by symmetrical distribution of skin lesions, polymorphic lesions, severe itching, tendency to exudate, and repeated attacks. The disease is lingering and difficult to heal, and the clinical treatment is difficult, which has caused a greater impact on the physical and mental health of patients. [0003] At present, Western medicine is mainly based on symptomatic treatment such as antihistamine drugs, glucocorticoid drugs, and astringent and protective drug preparations. Although these drugs can control symptoms, they are prone to relapse after drug withdrawal, and long-term, repeated, large-scale Area use can cause adverse reactions such as local...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/69A61K47/10A61K47/38A61P17/00A61P37/08
CPCA61K9/0024A61K9/06A61K31/69A61K47/10A61K47/38
Inventor 付任重陈航平杨博李建民肖海英马义成
Owner 苏州尚宜佳生物科技有限公司
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