Preparation method of skin-touch crisaborole slow-release film

A technology of crisborole and slow-release membrane, which is applied in the field of biomedical materials, can solve the problems of not being able to retain for a long time and being easily wiped, and achieve the effect of enhancing drug penetration and adhesion

Inactive Publication Date: 2018-11-23
苏州尚宜佳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the crisborole preparations are ointments, which do not involve sustained release,

Method used

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  • Preparation method of skin-touch crisaborole slow-release film

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Effect test

Embodiment 1

[0025] A. Membrane matrix preparation: Spandex and silk are used as the matrix material to weave the matrix, and the moisture-discharging strips are arranged at intervals on the matrix. The moisture-relieving strips are made of antibacterial yarn and acrylic fiber, and the interval width is 2-3mm. The width of the moisture strip is 2-3mm, which is the film-forming matrix;

[0026] B. Preparation of the first layer of slow-release film: Mix crisborole 20%, glycerin 25%, microcrystalline cellulose 25%, propylene glycol 7%, carrageenan 8%, and polyvinylpyrrolidone 15%, mix well, melt, melt The material in the state is evenly spread on the above-mentioned prepared film matrix;

[0027] C, the preparation of the second layer of delayed-release film: 20% of crisborole, 25% of propylene alcohol, 25% of sorbitol, 7% of polysorbate, 8% of guar gum, and 15% of polycarbophil are fully mixed, Add an appropriate amount of water to dissolve, stir evenly, spread it evenly on the above slow-...

Embodiment 2

[0030] A. Membrane matrix preparation: Spandex and silk are used as the matrix material to weave the matrix, and the moisture-discharging strips are arranged at intervals on the matrix. The moisture-relieving strips are made of antibacterial yarn and acrylic fiber, and the interval width is 2-3mm. The width of the moisture strip is 2-3mm, which is the film-forming matrix;

[0031] B. Preparation of the first layer of slow-release film: mix crisborole 25%, polyethylene glycol 23%, modified starch 22%, menthol 8%, carboxymethylcellulose sodium 7%, chitosan 15% fully, melt, and evenly smear the material in the molten state on the above-mentioned prepared film matrix;

[0032] C. Preparation of the second delayed-release film: mix crisborole 25%, triacetin 23%, dextrin 22%, menthol 8%, carboxymethylcellulose sodium 7%, and polyvinyl alcohol 15%. Fully, add appropriate amount of water to dissolve, stir evenly, spread it evenly on the above slow-release film, and dry it in a dryer ...

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Abstract

The invention discloses a preparation method of a skin-touch crisaborole slow-release film. The skin-touch crisaborole slow-release film is prepared from the following raw materials: an active component, a plasticizer, a filling agent, an absorption promoter, a suspending agent and an adhesive. According to the preparation method disclosed by the invention, the problem that the utilization frequency of a drug is too high is solved, longer skin retention time is provided and the number of times of drug administration is reduced; a film agent is prepared by matching various film-forming auxiliary materials and the materials are complementary to each other and are necessary; the film forming property is enhanced through the plasticizer and the filing agent and the penetration capability of the drug is enhanced through the absorption promoter; the dispersity of the raw materials under a liquid state is ensured through the suspending agent and the fitting degree between the film agent and skin is enhanced through the adhesive.

Description

technical field [0001] The invention relates to a preparation method of a skin-sensitive crisaborole sustained-release film, which belongs to the field of biomedical materials. Background technique [0002] Crisaborole, an inhibitor of phosphodiesterase 4 (PDE4), which results in increased intracellular levels of cyclic adenosine monophosphate (cAMP), is used in the treatment of fungal infections, more specifically Onychomycosis and / or fungal skin infections. The drug was approved for marketing by the U.S. Food and Drug Administration (FDA) in December 2016. It was developed by Anacor Pharmaceuticals and is responsible for marketing in the United States. The trade name is Crisaborole and its chemical name is 5-(4-cyanophenoxy )-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, the English name is 4-((1-hydroxy-1,3-dihydrobenzo[c][1, 2] oxaborol-5-yl)oxy)benzonitrile, the chemical structural formula is as shown in formula (I): [0003] [0004] The characteristic of drug sustain...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/69A61K47/34A61P31/10A61P17/00
CPCA61K9/0014A61K9/7023A61K31/69A61K47/34A61P17/00A61P31/10
Inventor 付任重李建民马义成肖海英
Owner 苏州尚宜佳生物科技有限公司
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