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Crisaborole dampness eliminating diuretic sustained-release membrane and preparation method thereof

A technology of criborole and slow-release film, applied in the field of biomedical materials, can solve the problems of not being able to be retained for a long time and being easy to be wiped

Inactive Publication Date: 2018-11-13
苏州尚宜佳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the crisborole preparations are ointments, which do not involve sustained release, need fixed-point administration, and are easy to be wiped off, so they cannot be kept for a long time

Method used

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  • Crisaborole dampness eliminating diuretic sustained-release membrane and preparation method thereof
  • Crisaborole dampness eliminating diuretic sustained-release membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A. Weigh the following raw materials: criborole 20mg, Sophora flavescens extract 1mg, Sperantosporum extract 1mg, modified starch 4mg, Carbopol 3mg, glycerin 12mg, dissolve the modified starch in deionized water to form a suspension ,spare;

[0026] B, Carbopol and glycerin are added in above-mentioned suspension, mix well;

[0027] C. Add criborole, Sophora flavescens extract and Sperantosporum extract to an appropriate amount of deionized water, and stir evenly;

[0028] D. The products obtained in B and C are mixed and stirred to obtain a uniform viscous substance;

[0029] E. Pour the viscous material obtained in D onto a glass plate, spread it evenly, and dry it in an oven at a temperature of 60°C. Cool, cut, and peel off the film to obtain the crisborole composite health-care slow-release film.

Embodiment 2

[0031] A. Weigh the following raw materials: criborole 35mg, Sophora flavescens extract 3mg, Sperantosporum extract 3mg, modified starch 7mg, Carbopol 6mg, glycerin 20mg, dissolve the modified starch in deionized water to form a suspension ,spare;

[0032] B, Carbopol and glycerin are added in above-mentioned suspension, mix well;

[0033] C. Add criborole, Sophora flavescens extract and Sperantosporum extract to an appropriate amount of deionized water, and stir evenly;

[0034] D. The products obtained in B and C are mixed and stirred to obtain a uniform viscous substance;

[0035] E. Pour the viscous material obtained in D onto a glass plate, spread it evenly, and dry it in an oven at a temperature of 60°C. Cool, cut, and peel off the film to obtain the crisborole composite health-care slow-release film.

Embodiment 3

[0037] A. Weigh the following raw materials: criborole 28mg, Sophora flavescens extract 2mg, Sperantosporum extract 2mg, modified starch 5.5mg, Carbopol 4.5mg, glycerin 16mg, and the modified starch was dissolved in deionized water to form a mixture Suspension, spare;

[0038] B, Carbopol and glycerin are added in above-mentioned suspension, mix well;

[0039] C. Add criborole, Sophora flavescens extract and Sperantosporum extract to an appropriate amount of deionized water, and stir evenly;

[0040] D. The products obtained in B and C are mixed and stirred to obtain a uniform viscous substance;

[0041] E. Pour the viscous material obtained in D onto a glass plate, spread it evenly, and dry it in an oven at a temperature of 60°C. Cool, cut, and peel off the film to obtain the crisborole composite health-care slow-release film.

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Abstract

The invention discloses a crisaborole dampness eliminating diuretic sustained-release membrane and a preparation method thereof. The membrane is prepared by the following raw materials: 9-18mg of crisaborole, 0.2-1.2mg of matrine extract, 0.2-1.2mg of garden balsam stem extract, 1-2.5mg of modified starch, 0.6-1.0mg of carbopol and 4-10mg of glycerol. The problem that the frequency of drug use istoo high is solved, longer skin retention time can be achieved, and the dosing times can be reduced. The resistant starch has good gelation property but loose structure. The addition of the carbopol and the glycerin can improve the structural strength, so that the materials are prone to form the membrane, and the yield is improved.

Description

technical field [0001] The invention relates to a slow-release film for dryness and diuresis of criborole and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Crisaborole, an inhibitor of phosphodiesterase 4 (PDE4), which results in increased intracellular levels of cyclic adenosine monophosphate (cAMP), is used in the treatment of fungal infections, more specifically Onychomycosis and / or fungal skin infections. The drug was approved for marketing by the U.S. Food and Drug Administration (FDA) in December 2016. It was developed by Anacor Pharmaceuticals and is responsible for marketing in the United States. The trade name is Crisaborole and its chemical name is 5-(4-cyanophenoxy )-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, the English name is 4-((1-hydroxy-1,3-dihydrobenzo[c][1, 2] oxaborol-5-yl)oxy)benzonitrile, the chemical structural formula is as shown in formula (I): [0003] [0004] The characteristic of d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K31/69A61K9/06A61K47/10A61K47/32A61K47/36A61P17/00A61P31/02A61P31/10A61P7/10
CPCA61K9/06A61K31/69A61K36/185A61K36/47A61K36/489A61K47/10A61K47/32A61K47/36A61P7/10A61P17/00A61P31/02A61P31/10A61K2300/00
Inventor 付任重李建民马义成肖海英
Owner 苏州尚宜佳生物科技有限公司
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