Organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere, preparation method and application of organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere

A technology of polyethyleneimine and silica, which is applied in the field of functional inorganic materials and analysis, can solve the problems of low adsorption capacity and weak affinity, and achieve the effect of low abundance

Active Publication Date: 2014-11-19
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most organic phenylboronic acid-functionalized materials have defects such as weak affinity and low adsorption capacity in the selective enrichment of cis-dihydroxy compounds, and cannot effectively enrich cis-dihydroxy compounds at very low concentrations in samples.

Method used

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  • Organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere, preparation method and application of organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere
  • Organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere, preparation method and application of organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere
  • Organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere, preparation method and application of organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of epoxypropyl functionalized 20 μm fully porous silica microspheres

[0042] Weigh 1 g of fully porous silica microspheres with a particle size of 20 μm, add 40 mL of dehydrated toluene, ultrasonically disperse, add 4 mL of γ-glycidyl etheroxypropyl trimethoxysilane (KH-560), stir magnetically, and protect with nitrogen. Reflux at 115°C for 24h. After the reaction, filter with suction, rinse with toluene, acetone, and anhydrous ether in sequence, and dry to obtain 20 μm fully porous silica microspheres functionalized with glycidyl groups.

Embodiment 2

[0043] Example 2: Preparation of epoxypropyl functionalized 1.4 μm non-porous silica microspheres

[0044] Weigh 1 g of non-porous silica microspheres with a particle size of 1.4 μm, add 40 mL of dehydrated toluene, ultrasonically disperse, add 4 mL of γ-glycidyl etheroxypropyl trimethoxysilane (KH-560), stir magnetically, and protect with nitrogen , 115 ° C reflux reaction for 24h. After the reaction, filter with suction, rinse with toluene, acetone, and anhydrous ether in sequence, and dry to obtain 1.4 μm non-porous silica microspheres functionalized with glycidyl groups.

Embodiment 3

[0045] Embodiment 3: the preparation of the silica microspheres of molecular weight 600Da polyethyleneimine modification

[0046] Take 1g of the epoxypropyl functionalized silica microspheres prepared in the above-mentioned Example 1 or Example 2, add 80mL of ethanol-water (1:1, v / v), after ultrasonic dispersion, add 0.75g of of polyethyleneimine. Magnetic stirring, nitrogen protection, placed in an oil bath at 65°C for reflux reaction for 12h. After the reaction, filter with suction, rinse with ultrapure water, absolute ethanol, and absolute ether in sequence, and dry to obtain polyethyleneimine-modified silica microspheres with a molecular weight of 600 Da.

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Abstract

The invention relates to the technical field of functional inorganic materials and analysis, and in particular relates to a preparation method of an organic phenylboronic acid-rich polyethyleneimine modified silicon dioxide microsphere. The preparation method comprises the following steps: (1) fixing polyethyleneimine molecules on the surface of the silicon dioxide microsphere; and (2) performing organic phenylboronic acid functional modification on the polyethyleneimine modified silicon dioxide microsphere. The silicon dioxide microsphere modified by the preparation method can perform enrichment and separation on the low-concentration cis-form dyhydroxyl compounds, so as to contribute to solving the problems of low abundance and more detection interference matters of cis-form dyhydroxyl compounds in the practical separated samples.

Description

technical field [0001] The invention relates to the technical field of functionalized inorganic materials and analysis, in particular to a method for preparing polyethyleneimine-modified silica microspheres rich in organic phenylboronic acid, and the silica microspheres prepared by the preparation method and its application. Background technique [0002] Cis-dihydroxy compounds are a class of compounds containing cis-dihydroxy structures, such as catechols, sugars, glycolipids, glycoproteins, glycopeptides, nucleosides and nucleotides. At present, these cis-dihydroxy compounds have shown important research value in the fields of traditional Chinese medicine, metabolomics, lipidomics, glycomics and proteomics, such as catechin and epicatechin in ginkgo and It exists in traditional Chinese medicines such as forsythia, and most of them have the functions of antidiarrheal, liver protection, lowering cholesterol, anti-inflammation, etc.; the main biological function of glycoprot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/286B01J20/30B01D15/38G01N1/34G01N1/40
Inventor 王彦薛芸施文君谷雪闫超
Owner SHANGHAI JIAO TONG UNIV
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