The invention belongs to the synthetic chemistry field, in particular to a synthesis process for ruthenium mixed-pyridine complex and derivative. Mixed-pyridine in ruthenium mixed-pyridine complex has two structures of (I) and (II), and the process comprises reacting ruthenium material and combined mixed-pyridine complex with various substituent position, complex kind (two teeth or three teeth, namely bipyridyl or terpyridyl material) and substituent property, and salt or water such as NCS, F, C1, Br, I and CN in a sealed reaction device which can be heated up and pressurized in one step or several steps for 0.5-48 hours under the temperature of 50-300 DEG C, thereby obtaining target product. The invention provides a high pressure synthesis process, which does not need a condensing reflux device, continuous inactive gas supply and inert atmosphere protection and has simple process. The process can increase reaction temperature over the boiling temperature of reaction solution in necessary, namely the boiling temperature relative to constant pressure, and has high reaction speed rate.