This invention discloses a
treatment plan optimization method and related equipment based on deterministic
coupling of
respiratory motion, relating to the field of radiotherapy technology. The method includes: acquiring multi-temporal 4DCT sequences of the patient and corresponding
respiratory motion curves; constructing a mapping relationship between
respiratory phase and organ position; establishing a
dynamic coupling mapping relationship between beam spot triggering time,
respiratory phase, and anatomical position; constructing a 4D
dose simulator based on the
dynamic coupling mapping relationship to simulate the
treatment plan and output a 4D
cumulative dose distribution; comparing the 4D
cumulative dose distribution with a preset clinical target, and if the error exceeds the tolerance range, activating an intelligent optimizer for optimization until the 4D
cumulative dose distribution meets clinical requirements, and outputting the current
treatment plan; achieving precise quantification and individualized adaptive compensation of the
impact of
respiratory motion, improving the realism of
proton therapy
dose deposition, the robustness of target coverage, and the optimization efficiency of the treatment plan.