A Raman probe for in situ puncture diagnosis in vivo

A Raman probe and puncture needle technology, which is applied in the directions of using spectrum diagnosis, diagnosis, Raman scattering, etc., to achieve the effects of reducing damage, simple structure and convenient disassembly

Inactive Publication Date: 2018-11-23
BEIJING JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Raman probe for in-situ puncture diagnosis provided by the present invention has the characteristics of simple structure, convenient operation, reusability, high sensitivity and reliability, and overcomes the problem that conventional Raman probes cannot penetrate deep into tissues in the body due to their large diameters. Insufficiency of body completion detection

Method used

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  • A Raman probe for in situ puncture diagnosis in vivo
  • A Raman probe for in situ puncture diagnosis in vivo
  • A Raman probe for in situ puncture diagnosis in vivo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1. Raman probes for in situ puncture detection in vivo

[0054] like figure 1 , figure 2 and Figure 7 As shown, the Raman probe used for in-situ puncture detection in the body of the present invention includes a Raman probe (the model is EN60825-1, and the manufacturer is Changchun New Industry Photoelectric Technology Co., Ltd.), and the Raman probe extension end 10 A third plano-convex lens 11 with a convex surface facing the near-outer end is provided inside, and a joint 13 and a puncture needle 15 are also included;

[0055] The joint 13 is a hollow pipe sleeve with two ends straight through;

[0056] The puncture needle 15 is a hollow tube straight through at both ends, and one end is needle-shaped, which is a needle point 19;

[0057] A thread a is provided on the inner wall of the first port of the joint 13, and a thread b is provided on the outer wall of the Raman probe extension end 10, the thread a matches the thread b, and the joint 13 and the R...

Embodiment 2

[0080] Embodiment 2, detect biological tissue

[0081] Use the Raman probe for in situ puncture detection in the body of Example 1 to detect pork samples—fat meat and lean meat respectively, and obtain the Raman spectrogram results as follows Figure 5 and Image 6 shown.

[0082] The results show that: the Raman signal obtained by the Raman probe used for in situ puncture detection in Example 1 is strong enough, and it can be found that the Raman signal intensity and translation width of the two samples are different on a specific Raman translation. .

[0083] The above results show that the Raman probe used in Example 1 for in situ puncture detection in vivo has high sensitivity and reliability.

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Abstract

The present invention relates to a Raman probe for in-vivo and in-situ puncture diagnosis. The Raman probe is in a puncture type, and can enter organ tissues in a human body for performing in-vivo and in-situ puncture detection and reduce damage by using an elongated needle for puncture or needle for biopsy to extend a conventional Raman probe. Optical components in a puncture needle cavity can achieve the extension of the incident light and the collection of scattered light. The Raman probe has the advantages of simple structure, convenient disassembly, easy disinfection, reusability, and high sensitivity and reliability, is suitable for in-vivo and in-situ detection of organ tissues and lesion analysis, and provides support and help for early accurate diagnosis and timely and accurate treatment for tumors. The Raman probe can be used for detecting the difference of the molecular structure of the biological tissue, and can also diagnose whether the organ tissue in the organism undergoes mutation or not according to the detected Raman signal.

Description

technical field [0001] The invention relates to the technical field of human tissue detection and analysis, in particular to a Raman probe capable of penetrating human organ tissues for in-situ diagnosis in vivo. Background technique [0002] Tumor is a new organism formed by the abnormal proliferation of local tissue cells under the action of tumorigenic factors, and can be divided into benign tumors and malignant tumors. Malignant tumors are extremely harmful and seriously affect human health. Tumor formation is accompanied by molecular structural abnormalities, showing differences from normal cells in pathological features. With the development of molecular medicine, the analysis of tumor molecular characteristic information can make a more accurate and comprehensive diagnosis, so as to better provide patients with personalized treatment measures. [0003] Raman spectroscopy is a method for molecular structure analysis based on the Raman scattering effect. Raman has fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00G01N21/65
CPCA61B5/0075A61B5/0084A61B5/6848G01N21/65
Inventor 杨唐文郑家文
Owner BEIJING JIAOTONG UNIV
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