49results about How to "Difficult to treat" patented technology

The present invention relates to a stent including a variable porosity, tubular structure having pores defined by structural surfaces. The tubular structure has a low porosity region in proximity to or at either end of the tubular structure, where the low porosity region is less porous than other regions located on the tubular structure and fully or partially obstructs passage of fluid. Any arcuate path that starts at one point within the low porosity region and goes around the perimeter of the tubular structure to stop at the same point within the low porosity region must have at least a portion that is outside of the low porosity region. Also disclosed is a method of modifying blood flow within and near an opening of an aneurysm in a blood vessel by deploying one or more stents of the present invention near an opening of the aneurysm in a blood vessel.

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide / glycolide) copolymer having a molar composition of lactide / glycolide from 90 / 10 to 40 / 60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100 / 0 to 1 / 99.

A wound therapy device and a kit for same with a housing material, a gasket disposed around at least a portion of the housing material, a non-woven absorption material, and a port. The gasket is sized and configured such that at least a first portion of the gasket will be adhered to a second portion of the gasket upon a folding of the housing material. A method of using a wound therapy device.

Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

A wound therapy device and a kit for same with a housing material, a gasket disposed around at least a portion of the housing material, a non-woven absorption material, and a port. The gasket is sized and configured such that at least a first portion of the gasket will be adhered to a second portion of the gasket upon a folding of the housing material. A method of using a wound therapy device.

An apparatus for treating tissue in a tissue treatment area includes a heater that does not contact the tissue. The apparatus may be attached to the skin of a person to form a treatment volume about the tissue to be treated. The heater, supported at the layer, is held near the tissue to be treated, out of contact with the tissue. The apparatus includes a controller to cause the heater to raise the temperature of tissue in the tissue treatment area to a temperature in a range from a pretreatment temperature to 38° C. The controller may include means that cause the heater to operate over a therapeutic sequence, that cycle the heater on and off, that provide selectable average temperature values, that cause the heater to operate over an average temperature range, that cause the heater to operate at an average temperature over a therapy cycle, or that cause the heater to operate at an average temperature over a therapeutic sequence.

A non-contact controllable heater wound covering and method having a peripheral sealing ring covered by a layer to which is attached a heater and this assembly is attached to the skin with an adhesive so that the heater is held proximate the wound area in a non-contact position. The layer and peripheral sealing ring together define a treatment volume proximate the wound. The wound covering includes a programmable active heater control and the sealing ring may dispense water to control the humidity of the treatment volume. One form of active heat is an electrical resistive filament in variable geometric shapes providing versatility in application of heat to different types of wounds and wound area geometries. Another form of active heat is the transfer of a heated gas to the wound covering.

Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions.

Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

A perfusion system is so formed that enclosed areas may be formed in the artery system related to the pancreas and the venous system related to the pancreas, respectively, by using balloon catheters, the blood inside the venous system in the enclosed area may be extracted outside the human body, and that, after injecting a pharmaceutical such as anticancer agent into the extracted blood, the extracted blood including pharmaceutical may be returned to the artery system in the enclosed area again.

A method of oral treatment comprises passing a flow of a gas mixture from a pressure vessel containing the gas mixture through a generator of non-thermal plasma; applying a partially ionising electrical potential to the flow of the gas mixture in the plasma generator, and thereby forming a non-thermal gaseous plasma in the gas mixture, and causing the flow of the gas mixture downstream of the plasma generator to perform the oral treatment. The gas mixture comprises (a) a noble gas selected from helium and argon and mixtures thereof, and (b) an additive gas selected from water vapour, air, oxygen, nitrogen, hydrogen, carbon monoxide, carbon dioxide, nitrous oxide and nitric oxide and mixtures of any two or more thereof. The additive gas forms up to 1% by volume of the gas mixture. The oral treatment may be the cosmetic whitening of teeth, the non-clinical cleaning of teeth or the in situ cleaning of orthodontic braces, amongst others.

This invention relates to deployable hemostatic materials comprising chitosan fibers. The hemostatic materials are suitable for use in sealing or controlling active bleeding from artery and vein lacerations and punctures, and for controlling oozing from tissue.

An optical connector is comprised of a main body and a wall formed in the main body and having a wall face which has guiding slots curving at an angle of about 90 degrees or one or more optical fiber holes. Optical fibers inserted into the main body along the lateral direction are made curved by the guiding slots or the optical fiber holes toward photoelectric devices disposed on an upper or lower face thereof.

An optical connector is comprised of a main body and a wall formed in the main body and having a wall face which has guiding slots curving at an angle of about 90 degrees or one or more optical fiber holes. Optical fibers inserted into the main body along the lateral direction are made curved by the guiding slots or the optical fiber holes toward photoelectric devices disposed on an upper or lower face thereof.

A passivated film on a surface of a high-alloy steel member makes it difficult to apply diffusion treatment, such as gas nitriding or gas carburizing, that forms a nitrided layer, carburized layer or carbonitrided layer on the surface of the steel member. An activating treatment method is provided for the surface of the metal member. This method is not accompanied by problems of conventional activation treatment with a halide, such as furnace deposits, furnace wall erosion and effluent gas detoxification treatment, and is useful as pretreatment for diffusion treatment. According to this method, the passivated surface of the high-alloy steel member can be activated by using a gas commonly employed in gas heat treatment, and forming HCN gas in a heating furnace while making use of catalytic action of the steel member or a surface of the furnace.

The present invention relates to methods for predicting the responsiveness of a patient to a breast cancer treatment regimen by assaying a biological sample to determine the level of expression of the long-chain fatty acyl-CoA synthetase 4 (ACSL4) in the biological sample. The present invention also provides ACSL4 inhibitors and uses of ACSL4 inhibitors as adjuvant therapies in breast cancer treatment regimens.

A functionalized copolymer containing a main chain derived from polymerizable monomers and pendent functional groups terminated with one or more α or β ethylenically or acetylenically unsaturated groups. The functionalized copolymers are self cross-linking and are suitable for use as binders.

The invention relates to feed for artificially raising forest musk deer and a preparation method thereof, and relates to the technical field of feed for artificially raising animals and a preparationmethod. The invention provides the feed for artificially raising the forest musk deer and the preparation method thereof. The feed for artificially raising the forest musk deer is particle feed prepared from coarse feed, fine feed, traditional Chinese herbal medicine and feed additives, and is characterized in that according to the mixing proportion of the coarse feed, the fine feed, the traditional Chinese herbal medicine and the feed additives, the coarse feed accounts for 60 to 70 weight parts; the fine feed accounts for 30 to 40 weight parts; the feed additives account for 1 to 5 parts; the traditional Chinese herbal medicine powder accounts for 1 to 5 weight parts. The feed has the functions of improving the feed palatability, improving the breeding rate and musk yield, and improvingthe feed intake; in addition, the feeding is convenient and sanitary; the storage is easy; the nutrition is balanced; the picky eating can be effectively avoided; the morbidity of the forest musk deeris reduced; the raising cost is reduced; the feed is suitable for large-scale industrial culture. The preparation method is simple; the finished product rate is high.

A wearable sanitizing system comprising a treatment substance dispenser typically affixed to a strap and securing a cartridge capable of containing a treatment substance. The treatment substance dispenser comprises an actuating portion that may dispense the contents of said cartridge. Buttons on the strap may facilitate actuation of a portion of the treatment substance dispenser. A computing device affixed to the strap comprises one or more wireless communications modules and one or more sensors. At least one of said sensors determines whether an actuation of the actuating portion occurred. The computing device may communicate with one or more servers and a cloud computing network.

A surface reforming method capable of efficiently carrying out a sustainable, even reforming treatment on a prescribed surface part of an element, a surface treatment liquid to be employed for the above-described method, and an element having a reformed surface treated by the above-described method. A part of the surface of an element is subjected to the reforming treatment by providing the object surface with a polymer, which is different from a constituent material of the objet surface and comprises a first part having a functional group and a second part having an interfacial energy different from that of the functional group and approximately equal to the surface energy of the object surface and orienting the second part of the polymer toward the object surface and orienting the first part in a direction different from the object surface.

A cogeneration process and system which provides for the reclamation of a grease fuel from a concentrated grease trap pumping waste stream and the use of said grease fuel in a compression ignition reciprocating engine for the production of electric power. The concentrated grease trap pumpings are heated and mixed in the first stage of the process to ensure all grease is liquefied. This warm mixed stream is then separated by centrifuge into a heavy stream consisting of water and sediments and an oil-rich stream consisting of oil, grease / water emulsion and residual water. This oil-rich mixture is heated sufficiently to evaporate the residual water as well as the water of emulsion yielding a water free grease fuel suitable for use in the compression ignition engine. Heat energy for grease liquefaction and emulsion breaking is supplied by an engine jacket water cooling circuit and an exhaust heat recovery, respectively.

The present invention provides a treatment system and method for rural black and odorous water and manure. The treatment method includes: (1) sending manure into a solid-liquid separation system, adding straws and / or saw-dust and chaff to solid obtained after the solid-liquid separation, adjusting a carbon-nitrogen ratio, sending into a solid aerobic fermentation system for aerobic fermentation, and then aging to produce organic fertilizer; (2) sending liquid obtained after the solid-liquid separation into a liquid anaerobic fermentation system for deep anaerobic fermentation; (3) sending biogas slurry after the deep anaerobic fermentation to a bio-membrane filter tank and a fibrous filter tank for treatment; (4) irrigating crops with the treated liquid or reusing the treated liquid in the farmland; and (5) soaking straws in manure slurry of a straw hydrolysis tank for hydrolysis, then pumping the softened straws to the solid-liquid separation system by using a cutting pump.

In order to adjust an amount of information to be simultaneously displayed on a display with identity of information to be displayed on a user interface (UI) screen guaranteed and to design a UI screen suitable for an assumed user, a UI creation support system (1) is provided which supports creating a UI screen for a predetermined service in which a plurality of user interface (UI) components are arranged, the UI creation support system (1) including a UI configuration determining unit (10) configured to determine a configuration of the UI screen, which includes all the plurality of UI components, for an assumed user using the UI screen according to the assumed user by adjusting the number of the UI components to be simultaneously displayed on a display.

There is provided a solid-state imaging device that includes: colored pixels each including a first photoelectric conversion element and a colored filler; white pixels each including a second photoelectric conversion element and a clear layer; and an interlayer insulating film provided between the first photoelectric conversion element and the colored filter, and between the second photoelectric conversion element and the clear layer. The colored filter is provided on light-entering side of the first photoelectric conversion element. The clear layer is provided on light-entering side of the second photoelectric conversion element. The clear layer has a higher refractive index than a refractive index of the colored filter, and includes an inorganic dielectric film made of a different material from a material of the interlayer insulating film.

A wound therapy device and a kit for same with a housing material, a gasket disposed around at least a portion of the housing material, a non-woven absorption material, and a port. The gasket is sized and configured such that at least a first portion of the gasket will be adhered to a second portion of the gasket upon a folding of the housing material. A method of using a wound therapy device.

The invention provides a traditional Chinese medicinal composition for treating recurrent oral ulcer, and relates to traditional Chinese medicinal compositions. The traditional Chinese medicinal composition is characterized by comprising the following raw materials in parts by weight: 10-15 parts of cortex phellodendri, 3-8 parts of coptis chinensis, 5-10 parts of scutellaria baicalensis, 30-50 parts of gypsum, 10-15 parts of radix asparagi, 10-15 parts of ophiopogon japonicus, 10-15 parts of cape jasmine, 10-15 parts of fructus forsythiae, 15-20 parts of rhizoma phragmitis, 10-15 parts of raw rehmannia root, 10-15 parts of prepared rehmannia root and 10-18 parts of dendrobe, as well as optional 10-30 parts of bamboo leaf, 3-8 parts of liquorice and 10-20 parts of lalang grass rhizome. The traditional Chinese medicinal composition for treating recurrent oral ulcer is unique in compatibility and smart in preparation, and has the advantages of good heat-clearing and internal fire-purging function, good treatment effect, quick curative effect, low treatment cost and hard relapse when being used for treating recurrent oral ulcer caused by hyperactivity of fire due to yin deficiency.

The present invention relates to a method of diagnosing atopic dermatitis through microbial metagenomic analysis, and more specifically, the present invention relates to a method of diagnosing atopic dermatitis by analyzing an increase or decrease in the content of specific bacteria- or archaea-derived extracellular vesicles by conducting a metagenome analysis using normal individual and subject-derived samples. Since the extracellular vesicles secreted from microorganisms present in the environment can be absorbed into the human body to regulate immune functions and directly affect the occurrence of inflammation. It is difficult to early diagnose atopic dermatitis before symptoms appear, and thus it is difficult to effectively treat the atopic dermatitis. Therefore, as the present invention can early diagnose and predict a risk group of atopic dermatitis by predicting the risk of developing atopic dermatitis through the metagenome analysis using human body-derived samples, it is possible to delay the onset time or prevent the onset of atopic dermatitis through proper management. In addition, the present invention enables early diagnosis even after onset, thereby lowering the incidence of atopic dermatitis and improving therapeutic effects.