A sensor resistance measurer consists of a power module, a keyboard module, a display module, a testing voltage source, a to-be-measured sensor, an operational amplifier, a feedback network, a polarity processing module, an A / D (analog / digital) converter and a numerical value processor. At least two feedback units are connected in parallel to form the feedback network. A sensor resistance measuring method is realized by the aid of measurement initialization, A / D conversion, polarity processing, automatic gear control, automatic zero point calibration and sensor resistance calculating software. A method for obtaining high precise resistance values includes that an attenuation type feedback network of a conventional precise-resistance-value resistor is adopted in a measuring amplifier, so that precise equivalent feedback resistance with the quite high value is obtained. The sensor resistance measurer and the method have the advantages that a high-resistance-value nano sensor with the resistance value higher than 1 G ohm can be precisely measured, large-range dynamic high-precision measurement is realized, voltage added on a resistor of the sensor can be confirmed and can be set in an optional range, a user does not need to adjust the voltage, any special production process requirements are omitted, the sensor resistance measurer is suitable for batch production, and the like.