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System and method for monitoring absolute blood flow

A technology of blood flow and blood flow, applied in the direction of blood flow measurement, intracranial pressure measurement, diagnostic recording/measurement, etc., can solve problems such as inability to continue, blockage of venous blood outflow, and high cost

Pending Publication Date: 2018-01-19
THE GENERAL HOSPITAL CORP
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Problems solved by technology

However, they have the disadvantages of requiring radiation, being expensive and slow, and cannot be performed continuously either at the bedside or in the field
However, these methods require complete occlusion of venous blood outflow, which can only be obtained by application of a blood pressure cuff or other device that modifies or restricts normal physiological flow conditions
Also, as can be appreciated, such methods are also limited to measurements on extremities of the body, such as arms or legs, since the use of devices that block blood flow to the brain is not recommended due to safety concerns

Method used

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  • System and method for monitoring absolute blood flow
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  • System and method for monitoring absolute blood flow

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[0032] Blood flow or tissue perfusion monitoring is useful in patients with a wide range of medical conditions and disorders (including traumatic brain injury, intracerebral and subarachnoid hemorrhage, hydrocephalus, benign intracranial hypertension, meningitis, stroke, acute liver failure, etc.) It is important for patients to be diagnosed and treated. In some cases, it is highly desirable to quantify blood flow absolutely in order to provide accurate comparisons between subjects, eg, so that standard blood flow levels can be defined and thresholds established for clinical intervention.

[0033] Thus, according to aspects of the present disclosure, a system and method for accurate, non-invasive monitoring of blood flow, including cerebral blood flow, is described herein. In particular, provided systems and methods utilize optical measurements, including diffusion correlated spectroscopy (DCS) measurements, to estimate absolute blood flow. In some aspects, the optical data m...

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Abstract

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical datafrom the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and. a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.

Description

[0001] Related - Cross References to Applications [0002] This application is based on, claims the benefit of, and cites U.S. Provisional Patent Application Serial No. 62 / 145,087, filed April 9, 2015, and entitled "SYSTEMS AND METHODS FORMEASURING TISSUE PRESSURE" The full text is incorporated here. [0003] Statement Regarding Federally Sponsored Research [0004] This invention was made with government support under Grant Nos. P41-EB015896, R01-HD042908, and R01-EB001954 awarded by the National Institutes of Health. The US Government has certain rights in this invention. Background technique [0005] The present disclosure generally relates to systems and methods for measuring tissue properties. More specifically, the present disclosure relates to systems and methods for noninvasively determining absolute blood flow using physiological measurements. [0006] Physiological monitoring of oxygen consumption by organs and the delivery of oxygen through the bloodstream is of...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61B5/02A61B5/026A61B5/0476A61B5/1455A61B5/1459
CPCA61B5/0205A61B5/0261A61B5/6814A61B5/0075A61B5/318A61B5/369A61B5/021A61B5/029A61B5/031A61B5/08A61B5/14546A61B5/14552A61B5/7246A61B5/7278A61B2562/0238
Inventor J·萨廷M·A·弗朗切斯奇尼D·博厄斯
Owner THE GENERAL HOSPITAL CORP
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