Blood purification column

A blood purification and blood technology, applied in the field of columns, can solve the problems of no exhaust concept and unsatisfactory exhaust, and achieve the effect of improving exhaust and not easy to coagulate.

Active Publication Date: 2015-09-09
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this invention, there is no idea about exhausting. On the contrary, it is made by wrapping the adsorbent with a mesh cloth for the purpose of stably maintaining the adsorbent in the column and improving the fluidity in the column. Arrangement of the above-mentioned mesh with openings parallel to the long axis direction of the column is not ideal from the viewpoint of degassing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] 31.7 parts by weight of syn-PMMA with a weight average molecular weight of 400,000, 31.7 parts by weight of syn-PMMA with a weight average molecular weight of 1.4 million, and 16.7 parts by weight of iso-PMMA with a weight average molecular weight of 500,000, containing 1.5 mol% 20 parts by weight of the PMMA copolymer with a molecular weight of 300,000 sodium p-styrene sulfonate was mixed with 376 parts by weight of dimethyl sulfoxide, and stirred at 110° C. for 8 hours to prepare a spinning dope. The obtained spinning dope had a viscosity of 1240 poise at 110°C. The obtained spinning dope was ejected into the air at a rate of 1.0 g / min from a nozzle (having a circular outlet with a diameter of 0.3 mm) kept at 93° C., and the air part was moved for 50 cm before being introduced into a coagulation bath. The water temperature (coagulation bath temperature) used in the coagulation bath was set at 42° C. to obtain a solid yarn. After each solid yarn was washed with water,...

Embodiment 2

[0094] Except that the ejection speed of the spinning stock solution was set at 1.9 g / min so that the filament diameter was 181 μm, a solid filament was obtained by the same method as in Example 1, and it was built in the same size as Example 1 in the same manner as in Example 1. In the casing with the same shape and the same shape, the screen filter and the head cap with the same size and shape as in Example 1 are arranged on both sides of the casing. The average circle-equivalent diameter of the adsorbent gap in this column was 135 μm. For this column, the air removal rate in the column was measured in the same procedure as in Example 1. The results are shown in Table 1.

Embodiment 3

[0096] Except that the ejection speed of the spinning dope was set at 0.5 g / min so that the filament diameter was 56 μm, a solid filament was obtained by the same method as in Example 1, and it was built in the same size as in Example 1 as in Example 1. In the casing with the same shape and the same shape, the screen filter and the head cap with the same size and shape as in Example 1 are arranged on both sides of the casing. The average circle-equivalent diameter of the adsorbent gaps in this column was 42 μm. For this column, the air removal rate in the column was measured in the same procedure as in Example 1. The results are shown in Table 1.

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Abstract

The present invention relates to a filter built into a blood purification column, and aims to dramatically improve the removal of air that gets into the column and to prevent blood activation due to air remaining inside of the column and decreased absorption performance due to decreased contact surface between blood and an absorbent. This blood purification column has an absorbent and a casing, both ends of which are open ends, and the absorbent is housed inside of the casing. Of the two ends of the casing, one is the blood inflow end and the other is the blood outflow end. A filter is arranged on the blood inflow end and / or the blood outflow end of the casing, and this filter fulfils the following conditions. (1) The opening ratio of the filter is 5-80% (2) The equivalent diameter of the openings in the filter is 1-5000μm (3) The ratio of the equivalent diameter of the openings to the average circle equivalent diameter of the gaps in the absorbent is 45% or greater.

Description

technical field [0001] The present invention relates to a column used for blood purification, etc., and relates to a blood purification column which is excellent in exhaust performance and hardly causes blood coagulation in a circuit during blood introduction. Background technique [0002] There is known a treatment method called apheresis therapy, in which the patient's blood is temporarily taken out of the body, and the pathogenic substances in the taken blood are removed by adsorption, filtration, etc., and the treated blood is The blood is sent back into the patient's body. This purification therapy is used in the treatment of drug poisoning, food poisoning, familial hypercholesterolemia, ulcerative colitis, Crohn's disease, and autoimmune diseases such as rheumatoid arthritis. It can be used to remove drugs, toxins, substances such as cholesterol (which are believed to be the cause of the above diseases), inflammatory cells such as white blood cells, platelets, etc. fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36
CPCA61M1/3672A61M2205/75A61M1/3627A61M1/3679B01J20/261B01J20/262B01J20/28023B01J20/2805A61M1/3644A61M1/3652B01J20/28019B01J20/28B01J20/26A61M1/14A61M1/36A61M60/113A61M1/3643
Inventor 藤枝洋晓上野良之田中和实
Owner TORAY IND INC
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