Blood purification equipment and medical systems

Abstract

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

Description

[0001] This application claims priority to Chinese Patent Application No. 202411982170.4, filed with the Chinese Patent Office on December 27, 2024, entitled "Blood Purification Equipment and Medical System", the entire contents of which are incorporated herein by reference. Technical Field

[0002] This invention relates to the field of medical device technology, and in particular to a blood purification device and medical system. Background Technology

[0003] Blood purification equipment typically works by drawing the patient's blood out of the body, removing certain metabolic wastes or toxic substances through a specific process, and then drawing the blood back into the body to purify the blood.

[0004] Taking CRRT (continuous renal replacement therapy) as an example, CRRT, as a common extracorporeal blood purification treatment technique, is a general term for treatment methods that continuously and slowly remove water and solutes. After the patient's blood is drawn out of the body, it is easy for coagulation to occur when the blood comes into contact with the tubing and dialysis membrane of the CRRT device. This necessitates the use of anticoagulants such as heparin and citrate during blood purification treatment to prevent thrombus formation.

[0005] The anticoagulant mechanism of citrate is as follows: calcium ions are essential factors in the coagulation cascade, and citrate achieves its anticoagulant effect by reversibly chelating calcium ions in the extracorporeal circulation. Therefore, infusing citrate into the arterial end of the extracorporeal circulation to maintain the extracorporeal circulation calcium level at a predetermined parameter (e.g., 0.25–0.40 mmol / L) can effectively achieve local anticoagulation. Simultaneously, supplementing the venous end with calcium-containing solutions such as calcium chloride or calcium gluconate, or using calcium-containing replacement fluid, can prevent hypocalcemia in patients.

[0006] However, currently, the supplementation of anticoagulants and calcium ions generally requires manual collection of blood samples or waste fluids, which are then sent to a laboratory or analyzed using a blood gas analyzer or electrolyte analyzer within the department. Blood sample or waste fluid testing is inconvenient, and doctors / nurses cannot obtain the results promptly. Furthermore, once the results are available, doctors / nurses need to manually adjust the flow rate / dosage of anticoagulants and / or calcium solutions based on experience, which is time-consuming, labor-intensive, and difficult to operate.

[0007] Therefore, how to easily adjust the anticoagulant drugs and calcium ions in the blood purification circuit has become a problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0008] In view of this, the present invention provides a blood purification device to facilitate the regulation of anticoagulant drugs and calcium ions in the blood purification circuit. The present invention also provides a medical system.

[0009] To achieve the above objectives, the present invention provides the following technical solution:

[0010] This invention provides a blood purification device, comprising:

[0011] Equipment housing;

[0012] Blood purifier;

[0013] A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel;

[0014] A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that causes an anticoagulant solution to flow into the first blood tubing and / or a second replenishment pump that causes a calcium solution to flow into the second blood tubing;

[0015] A blood component analysis component is disposed within the housing of the device and is used to detect the collected blood samples.

[0016] Optionally, the blood purification device described above further includes a controller;

[0017] The blood component analysis component processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller; alternatively, the blood component analysis component outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain a detection result.

[0018] Optionally, in the above-mentioned blood purification device, the anticoagulant solution is a citric acid solution, and / or the detection result includes at least the calcium ion concentration in the blood sample.

[0019] Optionally, in the above-mentioned blood purification equipment, the blood sample can be collected by an operator from the first blood line, the second blood line and / or the human blood vessel.

[0020] Optionally, in the above-mentioned blood purification device, the blood sample is a blood sample from the first blood tubing or a blood sample from the human blood vessel; or,

[0021] The blood sample is the blood sample from the second blood tubing.

[0022] Optionally, in the above-mentioned blood purification device, the device housing has a first side and a second side facing away from each other, and a third side located between the first side and the second side, wherein the first side is the side facing the operator;

[0023] The blood component analysis component has a detection position, and the blood sample can be placed at the detection position from outside the device housing. The detection position is located on the first, second, or third side of the device housing.

[0024] Optionally, in the above-mentioned blood purification device, the device housing has a receiving structure, and the receiving structure corresponds to the detection position;

[0025] The test card carrying the blood sample can be placed within the receiving structure to place the blood sample at the detection position.

[0026] Optionally, the blood purification device described above further includes a sampling component, which collects the blood sample from the first blood tubing and / or the second blood tubing.

[0027] Optionally, in the above-mentioned blood purification device, the sampling component is a sampling needle or a sampling tube; the sampling tube or the sampling needle is at least partially located inside the device housing.

[0028] Optionally, in the above-mentioned blood purification device, the blood sample is a blood sample in the first blood tubing; or, the blood sample is a blood sample in the second blood tubing.

[0029] Optionally, in the above-mentioned blood purification device, the controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump according to the detection result;

[0030] or,

[0031] The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

[0032] Optionally, in the above-mentioned blood purification device, the controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

[0033] Optionally, in the above-mentioned blood purification equipment, the blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration.

[0034] And / or, the blood component analysis component is capable of detecting one or more of the following values ​​of the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

[0035] Optionally, the blood purification device described above further includes an interactive component, which is communicatively connected to the blood component analysis component and is capable of outputting detection results of at least one ion concentration.

[0036] Optionally, in the above-mentioned blood purification device, the interactive component includes a display screen, which is used to display the test results, adjustment suggestions given based on the test results, and / or prompts indicating that corresponding adjustments have been made based on the test results;

[0037] Alternatively, the interactive component may include a voice component, which is used to output the detection result, adjustment suggestions based on the detection result, and / or a prompt indicating that corresponding adjustments have been made based on the detection result.

[0038] The present invention also provides a blood purification device, comprising:

[0039] Equipment housing, the equipment housing having a connecting portion;

[0040] Blood purifier;

[0041] A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel;

[0042] A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that causes an anticoagulant solution to flow into the first blood tubing and / or a second replenishment pump that causes a calcium solution to flow into the second blood tubing;

[0043] A blood component analysis component having a mating part connected to the connecting part, the blood component analysis component being used to detect collected blood samples.

[0044] Optionally, the blood purification device described above further includes a controller;

[0045] The blood component analysis component processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller; alternatively, the blood component analysis component outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain a detection result.

[0046] Optionally, in the above-mentioned blood purification device, the anticoagulant solution is a citric acid solution, and / or the detection results include at least the detection results of the calcium ion concentration in the blood sample.

[0047] Optionally, in the above-mentioned blood purification device, the controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump according to the detection result;

[0048] or,

[0049] The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

[0050] Optionally, in the above-mentioned blood purification device, the controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

[0051] Optionally, in the above-mentioned blood purification device, the connecting part and the mating part are detachably connected.

[0052] Optionally, in the above-mentioned blood purification device, the connecting part is a plug-in box with an opening located on the outer wall of the device housing and recessed into the device housing, and the mating part is the outer wall of the blood component analysis component;

[0053] The blood component analysis component can be plugged into the plug-in box.

[0054] Optionally, in the above-mentioned blood purification device, the connecting part is located on the outer wall of the device housing, and the mating part is located on the outer wall of the blood component analysis component and can be connected to the connecting part.

[0055] Optionally, in the above-mentioned blood purification equipment, the blood sample can be collected by an operator from the first blood line, the second blood line and / or the human blood vessel.

[0056] Optionally, in the above-mentioned blood purification device, the blood sample is a blood sample from the first blood tubing or a blood sample from the human blood vessel; or,

[0057] The blood sample is the blood sample from the second blood tubing.

[0058] Optionally, in the above-mentioned blood purification device, the blood component analysis component has a detection position and a receiving structure, wherein the receiving structure corresponds to the detection position;

[0059] The test card carrying the blood sample can be placed within the receiving structure to place the blood sample at the detection position.

[0060] Optionally, in the above-mentioned blood purification equipment, the blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration.

[0061] And / or, the blood component analysis component is capable of detecting one or more of the following values ​​in the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

[0062] Optionally, the blood purification device described above further includes an interactive component, which is communicatively connected to the blood component analysis component and is capable of outputting detection results of at least one ion concentration.

[0063] Optionally, in the above-mentioned blood purification device, the interactive component includes a display screen, which is used to display the test results, adjustment suggestions given based on the test results, and / or prompts indicating that corresponding adjustments have been made based on the test results;

[0064] Alternatively, the interactive component may include a voice component, which is used to output the detection result, adjustment suggestions based on the detection result, and / or a prompt indicating that corresponding adjustments have been made based on the detection result.

[0065] The present invention also provides a medical system, comprising:

[0066] A blood purification device, comprising a device housing, a blood purifier, a blood tubing assembly, and a power assembly; the blood tubing assembly includes a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; the power assembly includes a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing;

[0067] A blood gas analyzer is used to test blood samples. The blood gas analyzer and the blood purification equipment can be placed relatively independently but are connected in communication.

[0068] Optionally, in the above medical system, the blood purification device further includes a controller;

[0069] The blood gas analyzer processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller; alternatively, the blood gas analyzer outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain a detection result.

[0070] Optionally, in the above medical system, the controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the detection result;

[0071] or,

[0072] The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

[0073] Optionally, in the above medical system, the controller can provide adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

[0074] Optionally, in the above medical system, the blood purification device and the blood gas analysis device are installed in the same medical room.

[0075] Optionally, in the above medical system, there are multiple blood purification devices, and the blood gas analysis device is communicatively connected to multiple blood purification devices;

[0076] Alternatively, the number of blood purification devices may be one.

[0077] The present invention also provides a blood purification device, characterized in that it comprises:

[0078] Equipment housing;

[0079] Blood purifier;

[0080] A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel;

[0081] A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that causes an anticoagulant solution to flow into the first blood tubing and / or a second replenishment pump that causes a calcium solution to flow into the second blood tubing;

[0082] Controller;

[0083] A blood component analysis component is used to detect collected blood samples, and the blood component analysis component is communicatively connected to the controller.

[0084] Optionally, in the above-mentioned blood purification device, the blood component analysis component processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller; or, the blood component analysis component outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain the detection result.

[0085] Optionally, in the above-mentioned blood purification device, the controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump according to the detection result;

[0086] or,

[0087] The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

[0088] Optionally, in the above-mentioned blood purification device, the controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

[0089] Optionally, in the above-mentioned blood purification equipment, the blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration.

[0090] And / or, the blood component analysis component is capable of detecting one or more of the following values ​​of the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

[0091] Optionally, in the above-mentioned blood purification equipment, the blood sample can be collected by an operator from the first blood line, the second blood line and / or the human blood vessel.

[0092] Optionally, the blood purification device described above further includes an interactive component, which is communicatively connected to the blood component analysis component and is capable of outputting detection results of at least one ion concentration.

[0093] Optionally, in the above-mentioned blood purification device, the interactive component includes a display screen, which is used to display the test results, adjustment suggestions given based on the test results, and / or prompts indicating that corresponding adjustments have been made based on the test results;

[0094] Alternatively, the interactive component may include a voice component, which is used to output the detection result, adjustment suggestions based on the detection result, and / or a prompt indicating that corresponding adjustments have been made based on the detection result.

[0095] The present invention also provides a blood purification device, comprising:

[0096] Equipment housing;

[0097] Blood purifier;

[0098] A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing;

[0099] A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly;

[0100] A blood component analysis component is disposed within the housing of the device and is used to detect the collected blood samples.

[0101] The present invention also provides a blood purification device, comprising:

[0102] Equipment housing, the equipment housing having a connecting portion;

[0103] Blood purifier;

[0104] A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing;

[0105] A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly;

[0106] A blood component analysis component having a mating part connected to the connecting part, the blood component analysis component being used to detect collected blood samples.

[0107] Optionally, in the above-mentioned blood purification equipment, the blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration.

[0108] And / or, the blood component analysis component is capable of detecting one or more of the following values ​​of the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

[0109] Optionally, in the above-mentioned blood purification device, the anticoagulant solution flows into the first blood line through an external power device, and the calcium solution flows into the second blood line through an external power device.

[0110] Optionally, in the above-mentioned blood purification device, the blood component analysis component processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller of the blood purification device; or, the blood component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain the detection result.

[0111] The controller can issue a flow control signal to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or the flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line based on the detection results; or, the controller can provide flow rate adjustment suggestions for the anticoagulant solution flowing into the first blood line and / or the calcium solution flowing into the second blood line based on the detection results.

[0112] The present invention also provides a medical system, comprising:

[0113] Blood purification equipment, wherein the blood purification equipment is as described above;

[0114] An auxiliary power device, comprising a first replenishment pump that allows anticoagulant solution to flow into the first blood line and / or a second replenishment pump that allows calcium solution to flow into the second blood line.

[0115] Optionally, in the above medical system, the auxiliary power device is communicatively connected to the blood purification device;

[0116] The blood purification device further includes an interactive component, which includes a display screen for displaying the delivery flow rate of the first supplemental pump and / or the second supplemental pump.

[0117] And / or, the blood component analysis component processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller of the blood purification device; or, the blood component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain a detection result; the controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump according to the detection result; or, the controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump according to the detection result.

[0118] Optionally, in the above medical system, the auxiliary power equipment is relatively independent of the blood purification equipment;

[0119] The blood component analysis component processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller of the blood purification device; or, the blood component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain the detection result.

[0120] The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

[0121] Optionally, in the above medical system, the auxiliary power device has a display structure for displaying the delivery flow rate of the first supplemental pump and / or the second supplemental pump.

[0122] As can be seen from the above technical solution, the blood purification device provided by the present invention can perform blood sample testing on the human body through the blood component analysis component, thereby facilitating timely monitoring of the human body's blood status during the corresponding operation of the blood purification device, so as to adjust the corresponding pump in the power component accordingly, and facilitate the corresponding adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

[0123] The present invention also provides a blood purification device, comprising:

[0124] Equipment housing;

[0125] Blood purifier;

[0126] A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing;

[0127] A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly;

[0128] An electrolyte component analysis component is installed inside the device housing. The electrolyte component analysis component is used to detect waste liquid samples generated during blood purification operations.

[0129] The present invention also provides a blood purification device, comprising:

[0130] Equipment housing, the equipment housing having a connecting portion;

[0131] Blood purifier;

[0132] A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing;

[0133] A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly;

[0134] The electrolyte component analysis component has a mating part that connects to the connecting part, and the electrolyte component analysis component is used to detect and collect waste liquid samples generated during blood purification operations.

[0135] Optionally, in the above-mentioned blood purification equipment, the electrolyte component analysis component can detect one or more of the following concentrations in the waste liquid sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration.

[0136] Optionally, in the above-mentioned blood purification device, the power component further includes a first replenishment pump that allows the anticoagulant solution to flow into the first blood line and / or a second replenishment pump that allows the calcium solution to flow into the second blood line.

[0137] Optionally, in the above-mentioned blood purification device, the anticoagulant solution flows into the first blood line through an external power device, and the calcium solution flows into the second blood line through an external power device;

[0138] And / or, the blood purification device further includes a sampling component capable of collecting waste liquid samples from the waste liquid pipeline or waste liquid collection device of the blood purification device.

[0139] Optionally, in the above-mentioned blood purification device, the electrolyte component analysis component processes the detection signal of the waste liquid sample to obtain a first detection result and outputs the first detection result to the controller of the blood purification device; or, the electrolyte component analysis component outputs the detection signal of the waste liquid sample to the controller of the blood purification device so that the controller processes the detection signal to obtain the first detection result.

[0140] The controller can issue a flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line based on the first detection result; or, the controller can provide a flow rate adjustment suggestion for the calcium solution flowing into the second blood line based on the first detection result.

[0141] Optionally, the electrolyte composition analysis component is also used to detect the collected blood samples.

[0142] Optionally, in the above-mentioned blood purification device, the electrolyte component analysis component processes the detection signal of the blood sample to obtain a second detection result and outputs the second detection result to the controller of the blood purification device; or, the electrolyte component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain a second detection result.

[0143] Based on the second detection result, the controller can issue a flow control signal to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or a flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line; or, based on the second detection result, the controller can provide a flow control signal to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or a flow rate adjustment suggestion for the calcium solution flowing into the second blood line.

[0144] The blood purification device provided by this invention can detect the waste liquid sample generated during the blood purification operation through an electrolyte composition analysis component. This facilitates timely monitoring of the electrolyte concentration of the human body during the corresponding operation of the blood purification device, so as to adjust the corresponding pump in the power component accordingly and facilitate the corresponding adjustment of calcium ions in the blood purification circuit.

[0145] Since the blood purification equipment described above has the aforementioned technical effects, the medical system provided in this embodiment of the invention has the same technical effects, and will not be described in detail here. Attached Figure Description

[0146] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0147] Figure 1 This is a schematic diagram of a first structure of a blood purification device provided in an embodiment of the present invention;

[0148] Figure 2 This is a schematic diagram of a second structure of the blood purification device provided in an embodiment of the present invention;

[0149] Figure 3 This is a schematic diagram of the operation process of the blood purification device provided in an embodiment of the present invention;

[0150] Figure 4 This is a schematic diagram of the structure of a medical system provided in an embodiment of the present invention. Detailed Implementation

[0151] This invention discloses a blood purification device to facilitate the regulation of anticoagulant drugs and calcium ions in the blood purification circuit. This invention also provides a medical system.

[0152] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0153] like Figure 1 As shown, an embodiment of the present invention provides a blood purification device, including a device housing 100, a blood purifier, a blood tubing assembly, a power assembly, and a blood component analysis assembly 300.

[0154] The housing 100 can be used to house some of the functional components of the blood purification device. These functional components may include some or all of the components in the blood purifier, blood tubing assembly, power assembly, and blood component analysis assembly 300.

[0155] Taking CRRT equipment as an example, a blood purifier may include a filter for removing water and solutes from the blood.

[0156] The blood tubing assembly includes a first blood tubing connecting the human blood vessel to the inlet of a blood purifier, and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel. Through the first and second blood tubing, blood can circulate outside the human body. Specifically, the first blood tubing is used to transport blood to be purified from the human blood vessel to the blood purifier, and the second blood tubing is used to transport purified blood from the blood purifier to the human blood vessel.

[0157] The power assembly includes a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that allows anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump that allows calcium solution to flow into the second blood tubing. The blood pump is used in the first blood tubing. The blood pump is the power component, ensuring that the blood flowing within the blood tubing assembly flows at a certain rate, and can also control the flow rate of the blood within the blood tubing assembly. The first replenishment pump can control the flow of anticoagulant solution into the first blood tubing, including controlling whether the anticoagulant solution flows into the first blood tubing and the flow rate of the anticoagulant solution into the first blood tubing. By allowing the anticoagulant solution to flow into the first blood tubing through the first replenishment pump, the anticoagulant solution acts on the blood within the first blood tubing, preventing the blood from coming into contact with the tubing and filtration structure (such as dialysis membranes) of the blood purification equipment after flowing out of the blood vessels, thus preventing clotting and ensuring effective blood purification. The second supplemental pump controls the flow of calcium solution into the second blood tubing, including controlling whether the calcium solution flows into the second blood tubing and the flow rate of the calcium solution into the second blood tubing. By using the second supplemental pump to ensure that the calcium solution flows into the second blood tubing, it can act on the blood within the second blood tubing, preventing hypocalcemia or physical discomfort caused by the concentration of calcium ions in the blood being outside the standard range after entering the human blood vessels.

[0158] The first storage component for containing the anticoagulant solution and the second storage component for containing the calcium solution can be detachably installed on the blood purification device.

[0159] The blood component analysis component 300 is housed within the device housing 100 and is used to analyze collected blood samples. The blood sample is collected manually or automatically and placed in the detection position 310 by manual or mechanical operation, allowing the blood component analysis component 300 to analyze the blood sample.

[0160] The blood purification device provided in this embodiment of the invention can analyze human blood samples through the blood component analysis component 300, thereby facilitating timely monitoring of the human body's blood status during the corresponding operation of the blood purification device, so as to adjust the corresponding pump in the power component accordingly, and to facilitate the corresponding adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

[0161] Furthermore, by adjusting the calcium ion concentration in the blood purification circuit, discomfort caused by excessively high or low calcium ion levels can be avoided, allowing for timely detection and correction. Similarly, adjusting the anticoagulant levels in the blood purification circuit prevents the blood purification equipment from malfunctioning due to excessively high or low levels of anticoagulant medication, ensuring the effective implementation of blood purification procedures.

[0162] The blood purification circuit is the pathway for transporting blood within the blood purification equipment.

[0163] Therefore, for ease of adjustment and operation, in some embodiments, the blood purification device also includes a controller. The blood component analysis component 300 processes the detection signal of the blood sample to obtain the detection result and outputs the result to the controller. That is, after the blood component analysis component 300 detects the blood sample and obtains the detection signal, it further processes the signal to obtain the detection result (e.g., a specific concentration value). The detection result is transmitted to the controller, which can then perform corresponding processing on the blood purification device based on the result. This processing may include adjusting the power components (blood pump, first supplementary pump, or second supplementary pump) and controlling the start / stop of the blood purification device to avoid adverse effects caused by the concentration of blood components (including anticoagulant solution and calcium solution) not reaching the standard value. Since obtaining the detection result from the detection signal involves corresponding logical operations, in this embodiment, the blood component analysis component 300 has a component capable of independently implementing these logical operations, such as a circuit board. This component can be relatively independent from the main control board in the blood purification device.

[0164] In some embodiments, the blood purification device also includes a controller. The blood component analysis component 300 outputs a detection signal from the blood sample to the controller for processing and obtaining a detection result. That is, after the blood component analysis component 300 detects the blood sample and obtains a detection signal, it transmits the signal to the controller, which processes it to obtain a detection result (e.g., a specific concentration value). The controller can perform corresponding processing on the blood purification device based on the detection result. This processing may include adjusting the power components (blood pump, first supplementary pump, or second supplementary pump) and controlling the start / stop of the blood purification device to avoid adverse effects caused by the concentration of blood components (including anticoagulant solution and calcium solution) not reaching the standard value. The process of obtaining the detection result from the detection signal involves corresponding logical operations; in this embodiment, these logical operations are implemented by the controller. The controller can be the main control board of the blood purification device, and the unit implementing the above logical operations can be integrated into the main control board.

[0165] Systematic reviews of multiple randomized controlled trials (RCTs) have indicated that topical citrate anticoagulation provides superior cardiopulmonary bypass life compared to other anticoagulation modalities, with a lower risk of bleeding. Therefore, citrate solution is preferred as the anticoagulant. However, heparin or other components can also be used as the anticoagulant; that is, the anticoagulant solution can also be heparin solution or other solutions.

[0166] Furthermore, in the embodiment using citric acid as the anticoagulant component, i.e., the anticoagulant solution is a citric acid solution, and calcium ion concentration is used as an indicator of anticoagulant effect. Therefore, the detection results should at least include the calcium ion concentration in the blood sample.

[0167] Of course, other anticoagulant solutions can also be selected, and the test results should include at least other test components that can measure the anticoagulant effect, which will not be listed here and are all within the protection scope.

[0168] In some embodiments, blood samples may be collected by an operator from a first blood line, a second blood line, and / or a human blood vessel. The human blood vessel may be a vein. The sampling point of the first blood line may be a segment connecting the inlet of the blood purifier to the blood collection end of the body. The sampling point of the second blood line may be a segment connecting the outlet of the blood purifier to the blood return end of the body.

[0169] The device housing 100 has a detection position 310 for placing the collected blood sample. During the blood sample collection process, the blood sample can be placed outside the device housing 100 onto the detection position 310. That is, the detection position 310 is externally located so that the operator can easily transfer the blood sample to the detection position 310 after collecting it manually or with auxiliary equipment.

[0170] The detection position 310 is external. The blood sample can be a blood sample from the first blood tubing or a blood sample from a human blood vessel; or, the blood sample can be a blood sample from the second blood tubing. That is, the blood sample can be either a first-type blood sample or a second-type blood sample. The first-type blood sample is a sample of blood flowing from the human body into the blood purification device, i.e., a sample of blood drawn from the body and requiring processing by the blood purification device. To prevent blood from clotting due to contact with the blood transport tubing and purification structures (such as dialysis membranes), anticoagulants are added after the blood is drawn from the body. The collection point for the first-type blood sample must be before the section where the anticoagulant is added, and at a certain distance, to avoid the influence of the added anticoagulant on the test results of the first-type blood sample. The second-type blood sample is a sample of blood flowing back from the blood purification device to the body, i.e., a sample of blood that has been processed by the blood purification device and needs to flow back to the body. Because some of the chelated calcium is filtered out through the dialysis membrane when blood flows through a blood purifier, a calcium solution needs to be added before the blood is returned to the body to ensure that the blood calcium concentration is within the standard range and to avoid hypocalcemia or discomfort. The collection point for the second type of blood sample must be located before and at a certain distance from the section of tubing where the calcium solution is added, to avoid affecting the test results of the second type of blood sample. The second type of blood sample refers to the blood sample within the second blood tubing.

[0171] like Figure 1 As shown, the device housing 100 has a first surface 101 and a second surface facing away from each other, and a third surface 102 located between the first surface 101 and the second surface. The first surface 101 faces the operator. That is, during normal use, the operator faces the first surface 101 of the device housing 100 to operate the blood purification device. Other reference points can also be used as indicators of the position of the first surface 101; for example, the orientation of the first surface 101 can be consistent with the display direction of the main display screen 200 of the blood purification device. In blood purification devices where the main display screen 200 can rotate relative to the device housing 100, the main display screen 200 has the most commonly used placement state, and its display direction is the orientation of the first surface 101. Alternatively, the first surface 101 may have multiple operating components of the blood purification device, etc.

[0172] In some embodiments, the blood component analysis component has a detection position 310, on which a blood sample can be placed from outside the device housing. The detection position 310 is located on a first surface 101, a second surface, or a third surface 102 of the device housing 100. Preferably, to facilitate placing the collected blood sample on the detection position 310 of the blood component analysis component 300, the detection position 310 can be placed on the third surface 102, i.e., on the side of the device housing 100, to avoid interfering with the operator's routine operations on the blood purification device from the first surface 101 (such as controlling the main display screen 200 and observing the displayed data on the main display screen 200).

[0173] In this embodiment, the device housing has a receiving structure corresponding to the detection position 310. The test card 400 carrying the blood sample can be placed inside the receiving structure to allow the blood sample to be placed in the detection position 310. The test card 400 can be a test strip, a glass slide, or an electrode pad, etc. The test card 400 can be used as a disposable item. After carrying the blood sample and inserting it into the slot to complete the test, the operator can remove the test card 400 and discard it directly as medical waste in the appropriate waste bin, freeing up the slot for the next test. Alternatively, the test card 400 can be a reusable component. After carrying the blood sample and inserting it into the slot to complete the test, the operator can remove the test card 400 for cleaning and disinfection for future use.

[0174] The receiving structure can have the function of limiting or loading the test card 400. Specifically, the receiving structure can be a plug slot or a cavity with a door, etc.

[0175] In an embodiment where the receiving structure is a plug-in slot, the test card 400 can be plugged into the plug-in slot, and when the test card 400 is inserted into the plug-in slot, the blood sample carried by the test card 400 is correspondingly set with the detection position 310.

[0176] In embodiments where the accommodating structure is a cavity with a switchable door, the cavity can be located inside the device housing, and the switchable door serves to shield the cavity. The test card 400 can be placed inside the cavity by opening the switchable door, and the cavity can be closed by opening and closing the switchable door. With the test card 400 placed inside the cavity, the blood sample carried by the test card 400 is positioned corresponding to the detection position 310.

[0177] Of course, the containment structure can also be set to other structures.

[0178] Because the aforementioned receiving structure (plug slot or cavity with a switchable door) allows the blood sample carried by the test card 400 to be located inside the device housing, the detection end of the blood component analysis component 300 for detecting the blood sample is not exposed, effectively improving the protection of the blood component analysis component 300. In this embodiment, the blood component analysis component 300 can be integrated inside the device housing 100. Of course, the housing of the blood component analysis component 300 can also be fixed relative to the device housing 100.

[0179] Alternatively, the detection position 310 can be configured with other structures, such as a support platform, so that the blood sample or the test card 400 carrying the blood sample can be directly placed on the support platform, allowing the detection end of the blood component analysis component 300 to detect the blood sample placed directly or indirectly on the support platform. In this embodiment, the blood sample carried by the test card 400 can be located outside or inside the device housing.

[0180] In other embodiments, during the blood sample collection process, the blood sample can be placed from inside the device housing 100 into the detection position 310. That is, the detection position 310 is built into the device housing 100, reducing the chance of blood sample contamination during the detection process. The detection position 310 is enclosed by the device housing 100 to isolate it from the external environment of the blood purification device.

[0181] The blood purification device also includes a sampling component that collects blood samples from a first blood line and / or a second blood line. The sampling component collects blood samples from the first blood line, wherein the sampling site of the first blood line can be located outside the device housing 100, i.e., blood samples are collected from the section of the first blood line outside the device housing 100. Similarly, the sampling component collects blood samples from the second blood line, wherein the sampling site of the second blood line can be located outside the device housing 100, i.e., blood samples are collected from the section of the second blood line outside the device housing 100. One or more sampling components can be used to sample from the first and second blood lines. A single sampling component can be used to sample the first and second blood lines by moving its position; alternatively, multiple sampling components can be used to sample the first and second blood lines separately, meaning that the sampling points for the first blood line and the second blood line are different.

[0182] The sampling component is a sampling needle or a sampling tube, which is at least partially located within the device housing. In embodiments where the sampling component is a sampling needle, the sampling needle can pass through the sampling sites of the first and second blood tubes to sample the blood within the blood tubes. In embodiments where the sampling component is a sampling tube, the sampling tube can serve as a diversion tube between the first and second blood tubes, diverting the blood within the blood tubes and completing the sampling, so that the blood sample can reach the detection position 310 for detection under the guidance of the sampling tube.

[0183] Of course, the sampling component can also be other structures, as long as it can complete the sampling of blood in the first blood tubing and the second blood tubing and transfer it to the detection position 310 for detection. No specific restrictions are imposed here and all are within the scope of protection.

[0184] In this embodiment, the blood sample is either a blood sample from the first blood tubing or a blood sample from the second blood tubing. That is, the blood sample can be either a first-type blood sample or a second-type blood sample. A first-type blood sample can be a sample of blood flowing from the human body into the blood purification device, i.e., a sample of blood drawn from the human body and requiring processing by the blood purification device. To prevent blood from clotting due to contact with the blood-transmitting tubing and purification structure (such as a dialysis membrane), anticoagulants are added after the blood is drawn from the body. The collection point for the first-type blood sample must be before the section of tubing where the anticoagulant is added, and at a certain distance, to avoid the influence of the added anticoagulant on the test results of the first-type blood sample. The first-type blood sample is the blood sample from the first blood tubing. A second-type blood sample can be a sample of blood flowing back from the blood purification device to the human body, i.e., a sample of blood that has been processed by the blood purification device and needs to flow back to the human body. Because some of the chelated calcium is filtered out through the dialysis membrane when blood flows through a blood purifier, a calcium solution needs to be added before the blood is returned to the body to ensure that the blood calcium concentration is within the standard range and to avoid hypocalcemia or discomfort. The collection point for the second type of blood sample must be located before and at a certain distance from the section of tubing where the calcium solution is added, to avoid affecting the test results of the second type of blood sample. The second type of blood sample refers to the blood sample within the second blood tubing.

[0185] The adjustment range for anticoagulant and calcium solution flow rates is related to the concentrations of the anticoagulant and calcium solutions used. Doctors / nurses need to manually calculate the corresponding flow rate adjustment results. For example, a "Sodium Citrate-Calcium Local Anticoagulant Adjustment Chart" is attached to the CRRT device. Doctors / nurses refer to the chart to determine how to adjust the flow rates of sodium citrate and calcium solutions based on monitoring the calcium ion concentration after the filter and in the patient's blood. However, the flow rate of sodium citrate is related to the blood flow velocity, and the above chart format is only applicable to a specific blood flow velocity (e.g., 150 ml / min). Furthermore, the chart limits the solution to specific concentrations (e.g., commonly used citrate solutions include 4% high-concentration citrate (136 mmol / L) and low-concentration citrate solutions such as Baxter Regiocit (18 mmol / L); commonly used calcium solutions include 10% calcium gluconate and 5% calcium chloride). If other concentrations of sodium citrate or other calcium solutions are used, the above chart cannot be used to guide flow rate adjustment. Moreover, doctors / nurses need to manually look up tables and make calculations, which increases the chance of errors.

[0186] Therefore, to facilitate flow rate adjustment and reduce the probability of errors, in the blood purification device provided in this embodiment of the invention, the controller adjusts the flow rates of the first replenishment pump and / or the second replenishment pump based on the detection results. That is, the controller can perform corresponding processing on the blood purification device based on the detection results, including adjusting the flow rates of the first and second replenishment pumps. By adjusting the flow rate of the first replenishment pump, the flow rate of the anticoagulant solution into the first blood line is controlled, and the flow rate of the anticoagulant solution into the first blood line is adjusted, thereby regulating the concentration of anticoagulant components in the blood. By adjusting the flow rate of the second replenishment pump, the flow rate of the calcium solution into the second blood line is controlled, and the flow rate of the calcium solution into the second blood line is adjusted, thereby regulating the concentration of calcium ions in the blood. The controller can adjust the flow rates of the first and / or second replenishment pumps based on the detection results to achieve automatic adjustment.

[0187] This also allows operators to directly access the test results, enabling them to adjust the flow rates of the first and / or second supplementary pumps based on these results. The test results may include specific concentration values, as well as indications of elevated or low levels of certain components (such as "Post-filter (venous) free calcium concentration: 0.45 mmol / L (high)"), allowing operators to manually adjust the flow rates of the first and / or second supplementary pumps accordingly.

[0188] The controller can also provide adjustment suggestions for the first and / or second supplementary pumps based on the detection results. These suggestions may include specific adjustment information for the first and / or second supplementary pumps. For example, it may include instructions such as "It is recommended to increase the flow rate of 4% sodium citrate by 5 ml / h," allowing operators to obtain adjustment suggestions and determine whether adjustments are necessary based on the actual situation. Because of individual differences among different organisms, obtaining these adjustment suggestions allows operators to consider the individual differences of the patient being treated and determine whether adjustments are needed, as well as to increase or decrease the flow rate accordingly.

[0189] Specifically, the blood component analysis unit 300 can detect one or more of the following concentrations in a blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration. Taking sodium ion concentration as an example, during blood purification treatment, for patients with hypernatremia or hyponatremia, the blood component analysis unit 300 detects the sodium ion concentration in the blood sample to monitor the sodium ion concentration and facilitate timely detection and correction of these conditions. Similarly, during blood purification treatment, for patients with hyperkalemia, hypokalemia, or other electrolyte abnormalities, it is also necessary to regularly monitor the concentrations of the corresponding electrolytes in the blood.

[0190] During the monitoring of the aforementioned ion concentrations, the blood purification equipment can also issue warnings based on the test results, reminding doctors / nurses to promptly identify and address any issues with the patient. For example, it could provide a warning message such as, "Sodium ion concentration is too high, please take action!" The equipment can also present the concentrations of various ions monitored at different time points in a trend graph format, facilitating doctors / nurses' observation and review of the patient's condition throughout the entire treatment process.

[0191] Furthermore, the blood component analysis component 300 can also detect one or more of the following values ​​in a blood sample: pH (hydrogen ion concentration), pCO2 (partial pressure of carbon dioxide), pO2 (partial pressure of oxygen), Glu (glucose), Lac (lactate), and Hct (hematocrit). These corresponding detection operations allow operators to process the results appropriately.

[0192] To facilitate operators in obtaining test results, the blood purification equipment also includes an interactive component. This interactive component is communicatively connected to the blood component analysis module 300 and can output test results for at least one ion concentration. The interactive component enables interaction between the test results of the blood component analysis module 300 and the operator, allowing the operator to obtain the test results for at least one ion concentration from the blood component analysis module 300 via the interactive component.

[0193] Specifically, in some embodiments, the interactive component includes a display screen for displaying test results, adjustment suggestions based on the test results, and / or prompts indicating that corresponding adjustments have been made based on the test results. The display screen can be independent of the main display screen 200 of the blood purification device, or it can be integrated into the main display screen 200 of the blood purification device.

[0194] In other embodiments, the interactive component includes a voice component, which is used to output detection results, adjustment suggestions based on the detection results, and / or prompts indicating that corresponding adjustments have been made based on the detection results. The voice component can be a speaker or a signal transmission component connected to an external speaker, etc. The prompts broadcast by the voice component can be set as needed to facilitate the output of information in different languages.

[0195] like Figure 1 and Figure 3 As shown, a specific operating procedure of the blood purification device provided in this embodiment of the invention is as follows:

[0196] Collect a blood sample from the first blood tubing. This process can be performed manually or automatically.

[0197] Place the blood sample in the detection position 310. The blood sample can be placed directly in the detection position 310, or it can be placed indirectly in the detection position 310 through the test card 400 that carries the blood sample.

[0198] The blood component analysis component detects the concentration of calcium ions in a blood sample and transmits the results to the controller.

[0199] The controller performs corresponding processing based on the detection results, including a first processing measure, a second processing measure, and a third processing measure;

[0200] The first treatment measure can be that the controller adjusts the flow rate of the first replenishment pump or the second replenishment pump according to the detection results, so as to adjust the flow rate of the citrate solution or calcium solution into the first replenishment pump or the second blood line (for example, if the blood sample detection result in the first blood line shows that the calcium ion concentration is greater than 1.2 mmol / L, and the calcium solution flowing into the second blood line is 10% calcium gluconate, the flow rate of the second replenishment pump is reduced by 3 ml / h).

[0201] The second processing measure can be that the controller provides a suggestion to adjust the flow rate of the first or second replenishment pump based on the detection results. After the user confirms, the blood purification equipment then adjusts the flow rate of the first or second replenishment pump to adjust the flow rate of citrate solution or calcium solution into the first replenishment pump or the second blood tubing (e.g., the display screen of the interactive component displays or the voice prompts "The calcium ion concentration in the blood sample in the first blood tubing is greater than 1.2 mmol / L, and the calcium solution flowing into the second blood tubing is 10% calcium gluconate. It is recommended to reduce the flow rate of the second replenishment pump by 3 ml / h. Do you confirm the change?" After the user confirms, the flow rate of the second replenishment pump is changed).

[0202] The third processing measure is for the controller to provide suggestions on adjusting the flow rate of the first or second supplementary pump based on the detection results, so that the user can decide whether to adjust the first or second supplementary pump independently (e.g., the display screen of the interactive component shows or the voice message announces "the calcium ion concentration in the blood sample in the first blood tubing is greater than 1.2 mmol / L", which is used to remind the operator to decide whether to adjust the second supplementary pump independently based on the detection results).

[0203] like Figure 2 As shown, this embodiment of the invention also provides a blood purification device, including a device housing 100, a blood purifier, a blood tubing assembly, a power assembly, and a blood component analysis assembly 300.

[0204] The housing 100 can be used to house some of the functional components of the blood purification device. These functional components may include some or all of the aforementioned blood purifier, blood tubing assembly, and power assembly.

[0205] Taking CRRT equipment as an example, a blood purifier may include a filter for removing water and solutes from the blood.

[0206] The blood tubing assembly includes a first blood tubing connecting the human blood vessels to the inlet of a blood purifier, and a second blood tubing connecting the outlet of the blood purifier to the human blood vessels. Through the first and second blood tubing, blood can circulate outside the human body. Specifically, the first blood tubing is used to transport blood to be purified from the human blood vessels to the blood purifier, and the second blood tubing is used to transport purified blood from the blood purifier to the human blood vessels.

[0207] The power assembly includes a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that allows anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump that allows calcium solution to flow into the second blood tubing. Similarly, the blood pump is used in the first blood tubing and serves as the power component, causing the blood flowing within the blood tubing assembly to flow at a certain velocity. The blood pump can also control the flow velocity of the blood within the blood tubing assembly. The first replenishment pump can control the flow of anticoagulant solution into the first blood tubing, including controlling whether the anticoagulant solution flows into the first blood tubing and the flow rate of the anticoagulant solution into the first blood tubing. By allowing the anticoagulant solution to flow into the first blood tubing via the first replenishment pump, the anticoagulant solution acts on the blood within the first blood tubing, preventing the blood from coming into contact with the tubing of the blood purification device and the filtration structure (such as a dialysis membrane) of the blood purifier after flowing out of the blood vessels, thus preventing clotting and ensuring effective blood purification. The second supplemental pump controls the flow of calcium solution into the second blood tubing, including controlling whether the calcium solution flows into the second blood tubing and the flow rate of the calcium solution into the second blood tubing. By using the second supplemental pump to ensure that the calcium solution flows into the second blood tubing, it can act on the blood within the second blood tubing, preventing hypocalcemia or physical discomfort caused by the concentration of calcium ions in the blood being outside the standard range after entering the human blood vessels.

[0208] The first storage component for containing the anticoagulant solution and the second storage component for containing the calcium solution can be detachably installed on the blood purification device.

[0209] In this embodiment, the device housing 100 has a connecting portion, and the blood component analysis component 300 has a mating portion that connects to the connecting portion. The blood component analysis component is used to detect collected blood samples.

[0210] The blood component analysis component 300 may have a detection position 310. The blood component analysis component 300 can be connected to the device housing 100 via a mating part to achieve a physical connection between the blood component analysis component 300 and the device housing 100. When the connecting part and the mating part are connected, the blood component analysis component 300 has an exposed detection position 310, which can hold a collected blood sample, and the blood component analysis component 300 can detect the blood sample at the detection position 310.

[0211] Similarly, the blood purification device provided in this embodiment of the invention facilitates the corresponding adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

[0212] Furthermore, by adjusting the calcium ion concentration in the blood purification circuit, discomfort caused by excessively high or low calcium ion levels can be avoided, allowing for timely detection and correction. Similarly, adjusting the anticoagulant levels in the blood purification circuit prevents the blood purification equipment from malfunctioning due to excessively high or low levels of anticoagulant medication, ensuring the effective implementation of blood purification procedures.

[0213] The blood purification device in this embodiment also includes a controller, wherein the blood component analysis component 300 processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller, or the blood component analysis component 300 outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain the detection result.

[0214] Furthermore, as described in the previous blood purification device description, the anticoagulant solution is a citric acid solution, and / or the test results include at least the test results of the calcium ion concentration in the blood sample. Of course, heparin or other components can also be used as the anticoagulant; that is, the anticoagulant solution can also be a heparin solution or other solutions.

[0215] The control method of the controller is the same as or similar to that of the controller described in the previous blood purification device, and will not be described in detail here.

[0216] To improve the flexibility of the blood purification equipment, the connecting part and the mating part are detachably connected. That is, by disassembling the connecting part and the mating part, the blood component analysis component 300 can be made independent of the other structures of the blood purification equipment, facilitating maintenance operations such as charging or replacing the blood component analysis component 300. The blood component analysis component 300 may have a power supply battery. When charging the blood component analysis component 300, the power supply battery stores electricity to power the blood component analysis component 300's blood sample testing operation. In other words, the blood component analysis component 300 can be powered by the power supply battery without an external power source (e.g., not electrically connected to the power supply structure of the blood purification equipment).

[0217] like Figure 2As shown, in one specific embodiment, the connecting part is a plug-in box 110 with an opening located on the outer wall of the device housing 100 and recessed into the device housing 100, and the mating part is the outer wall of the blood component analysis component 300; the blood component analysis component 300 can be inserted into the plug-in box 110. That is, the blood component analysis component 300 can be plugged into the plug-in box 110 of the device housing 100 as a plug-in, thereby improving the stability of the connection between the blood component analysis component 300 and the device housing 100. Furthermore, corresponding connectors can also be provided in the plug-in box 110 to facilitate electrical connection with other components of the blood purification equipment (such as the power component or the main display screen 200) when the blood component analysis component 300 is located in the plug-in box 110, thereby realizing communication connection or power supply connection, etc.

[0218] In other specific embodiments, the connecting part is located on the outer wall of the device housing 100, and the mating part is located on the outer wall of the blood component analysis component 300 and can be connected to the connecting part. The connecting part can be a hook, and the mating part can be an opening or hook that mates with the hook.

[0219] Since the blood component analysis component 300 is connected to the device housing 100 and the detection position 310 is exposed, by adjusting the relative position of the blood component analysis component 300 and the device housing 100, the device housing 100 can be made to not obstruct the detection position 310, and the blood sample can be placed outside the device housing 100 at the detection position 310. The blood sample can be collected by the operator from the first blood line, the second blood line and / or human blood vessels.

[0220] The blood sample can be either a blood sample from the first blood tubing or a blood sample from a human blood vessel; or, the blood sample can be a blood sample from the second blood tubing. In other words, the blood sample can be either a first-type blood sample or a second-type blood sample. A first-type blood sample is a blood sample from the first blood tubing or a blood sample from a human blood vessel; a second-type blood sample is a blood sample from the second blood tubing.

[0221] The blood component analysis component 300 has a receiving structure corresponding to the detection position 310. The receiving structure can be a slot or a cavity with a switchable door, etc. The blood component analysis component 300 can detect one or more of the following concentrations in a blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration; and / or, the blood component analysis component 300 can detect one or more of the following values ​​in a blood sample: pH value, pCO2 value, pO2 value, Glu value, Lac value, and Hct value. Furthermore, the blood purification device may also include interactive components. Components identical or similar to the controller described in the previous blood purification device are not described in detail here and are all within the scope of protection.

[0222] This invention also provides a medical system, including a blood purification device and a blood gas analysis device. The blood purification device includes a housing 100, a blood purifier, a blood tubing assembly, and a power assembly. The blood tubing assembly includes a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel. The power assembly includes a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing. The blood gas analysis device is used to test blood samples. The blood gas analysis device and the blood purification device can be placed relatively independently but are communicatively connected. The blood purification device and the blood gas analysis device can be placed relatively independently to improve the layout flexibility of the medical system.

[0223] The blood gas analyzer can have the same function as the blood component analyzer 300 mentioned above, and will not be described in detail here.

[0224] Since the blood purification equipment described above has the aforementioned technical effects, the medical system provided in this embodiment of the invention has the same technical effects, and will not be described in detail here.

[0225] Similarly, the blood purification equipment also includes a controller; the blood gas analyzer processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller, or the blood gas analyzer outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain the detection result.

[0226] Furthermore, the controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the detection results; or, the operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the detection results.

[0227] It also enables the controller to provide adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

[0228] For ease of use, the blood purification equipment and blood gas analysis equipment are housed in the same medical room. This arrangement facilitates communication between the two devices. The medical room can be a separate room or divided by a certain area, such as within a larger space with a pre-defined area (e.g., a floor area of ​​10*10m). 2 It serves as a medical room.

[0229] To simplify equipment and save space, the medical system provided in this embodiment of the invention includes multiple blood purification devices, with a blood gas analyzer communicating with each of these devices. That is, the blood gas analyzer can be shared by multiple blood purification devices. Alternatively, the number of blood gas analyzers can be multiple, each corresponding to and communicating with a specific blood purification device.

[0230] Of course, it could also mean having a blood purification device in the medical system.

[0231] This invention also provides a blood purification device, including a device housing 100, a blood purifier, a blood tubing assembly, a power assembly, a controller, and a blood component analysis assembly 300.

[0232] The blood component analysis component 300 is used to detect the collected blood samples and is connected to the controller.

[0233] The blood purification device provided in this embodiment of the invention can analyze human blood samples through the blood component analysis component 300, thereby facilitating timely monitoring of the human blood status during the corresponding operation of the blood purification device. The blood component analysis component is connected to the controller for communication, so as to adjust the corresponding pump in the power component accordingly, which facilitates the corresponding adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

[0234] Furthermore, the blood component analysis component 300 processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller; or, the blood component analysis component 300 outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain the detection result.

[0235] The controller's control methods for other components in the blood purification device are the same as or similar to those in the aforementioned blood purification device, and will not be described in detail here. Furthermore, the detection capabilities of the blood component analysis component 300, the source of the blood sample, and the functions of the interactive components are the same as or similar to those in the aforementioned blood purification device, and will not be repeated here.

[0236] In some other embodiments, the blood purification device includes a housing 100, a blood purifier, a blood tubing assembly, a power assembly, and a blood component analysis assembly 300.

[0237] The housing 100 can be used to house some of the functional components of the blood purification device. These functional components may include some or all of the components in the blood purifier, blood tubing assembly, power assembly, and blood component analysis assembly 300.

[0238] Taking CRRT equipment as an example, a blood purifier may include a filter for removing water and solutes from the blood.

[0239] The blood tubing assembly includes a first blood tubing connecting the human blood vessel to the inlet of a blood purifier, and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel. Through the first and second blood tubing, blood can circulate outside the human body. The first blood tubing transports blood to be purified from the human blood vessel to the blood purifier, while the second blood tubing transports purified blood from the blood purifier to the human blood vessel. An anticoagulant solution can flow into the first blood tubing, and a calcium solution can flow into the second blood tubing. The flow rate of the anticoagulant solution into the first blood tubing can be controlled by a device (relatively independent of the blood purification equipment). Similarly, the flow rate of the calcium solution into the second blood tubing can be controlled by a device (relatively independent of the blood purification equipment). The system utilizes a two-step process: first, an anticoagulant solution flows into the first blood tubing, ensuring that the solution acts on the blood within that tubing. This prevents the blood from coming into contact with the tubing and filtration structure (such as the dialysis membrane) of the blood purification equipment after leaving the blood vessels, thus preventing clotting and ensuring effective blood purification. Second, a calcium solution flows into the second blood tubing, ensuring that the solution acts on the blood within that tubing. This prevents hypocalcemia or other discomfort caused by calcium ion concentrations outside the blood vessels. The first device for infusing the anticoagulant solution and the second device for infusing the calcium solution can be detachably mounted on the blood purification equipment or installed separately.

[0240] The blood component analysis component 300 is used to analyze collected blood samples. The blood component analysis component 300 can be housed within the device housing 100. The blood sample is collected manually or automatically and placed in the detection position 310 by manual or mechanical operation, allowing the blood component analysis component 300 to analyze the blood sample. Alternatively, the device housing 100 can have a connecting portion, and the blood component analysis component 300 can have a mating portion that connects to the connecting portion. The blood component analysis component is used to analyze collected blood samples.

[0241] The blood purification device provided in this embodiment of the invention can analyze human blood samples through the blood component analysis component 300, thereby facilitating timely monitoring of the human body's blood status during the corresponding operation of the blood purification device, so as to adjust the corresponding pump in the power component accordingly, and to facilitate the corresponding adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

[0242] Specifically, the blood component analysis unit 300 can detect one or more of the following concentrations in a blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration. Taking sodium ion concentration as an example, during blood purification treatment, for patients with hypernatremia or hyponatremia, the blood component analysis unit 300 detects the sodium ion concentration in the blood sample to monitor the sodium ion concentration and facilitate timely detection and correction of these conditions. Similarly, during blood purification treatment, for patients with hyperkalemia, hypokalemia, or other electrolyte abnormalities, it is also necessary to regularly monitor the concentrations of the corresponding electrolytes in the blood.

[0243] During the monitoring of the aforementioned ion concentrations, the blood purification equipment can also issue warnings based on the test results, reminding doctors / nurses to promptly identify and address any issues with the patient. For example, it could provide a warning message such as, "Sodium ion concentration is too high, please take action!" The equipment can also present the concentrations of various ions monitored at different time points in a trend graph format, facilitating doctors / nurses' observation and review of the patient's condition throughout the entire treatment process.

[0244] Furthermore, the blood component analysis component 300 can also detect one or more of the following values ​​in a blood sample: pH (hydrogen ion concentration), pCO2 (partial pressure of carbon dioxide), pO2 (partial pressure of oxygen), Glu (glucose), Lac (lactate), and Hct (hematocrit). These corresponding detection operations allow operators to process the results appropriately.

[0245] As shown in the above embodiments, the power component of the blood purification device further includes a first replenishment pump that allows the anticoagulant solution to flow into the first blood line and / or a second replenishment pump that allows the calcium solution to flow into the second blood line. The first replenishment pump can control the flow of the anticoagulant solution into the first blood line, including controlling whether the anticoagulant solution flows into the first blood line and the flow rate of the anticoagulant solution into the first blood line. By allowing the anticoagulant solution to flow into the first blood line through the first replenishment pump, the anticoagulant solution acts on the blood within the first blood line, preventing the blood from coming into contact with the tubing and filtration structure (such as a dialysis membrane) of the blood purification device after flowing out of the blood vessels, thus ensuring effective blood purification. The second replenishment pump can control the flow of the calcium solution into the second blood line, including controlling whether the calcium solution flows into the second blood line and the flow rate of the calcium solution into the second blood line. The second replenishment pump allows the calcium solution to flow into the second blood line, thereby enabling the calcium solution to act on the blood in the second blood line and preventing hypocalcemia or physical discomfort caused by the concentration of calcium ions in the blood not being within the standard range after the blood flows into the human blood vessels.

[0246] Alternatively, the anticoagulant solution can be propelled into the first blood line via an external power source, and the calcium solution can be propelled into the second blood line via an external power source. It is understood that the external power source can be a device relatively independent of the blood purification device provided in this embodiment of the invention; the two can be connected wirelessly or via wired communication, or they can be completely independent without any connection structure.

[0247] The external power equipment includes a first replenishment pump that allows the anticoagulant solution to flow into the first blood line and / or a second replenishment pump that allows the calcium solution to flow into the second blood line. That is, the first and / or second replenishment pumps are not part of the blood purification equipment; they are independent of it. The first and / or second replenishment pumps can be controlled independently, or the blood purification equipment can be communicatively connected to them.

[0248] That is, the anticoagulant solution can flow into the first blood line, which can be achieved by the first replenishment pump included in the power component of the blood purification device, or by the first replenishment pump included in the external power device; the calcium solution can flow into the second blood line, which can be achieved by the second replenishment pump included in the power component of the blood purification device, or by the second replenishment pump included in the external power device.

[0249] The first replenishment pump has an output line that can be connected to an anticoagulant solution bag at one end and to an interface on the first blood line at the other end, so as to allow the anticoagulant solution to flow into the first blood circuit; the second replenishment pump has an output line that can be connected to a calcium solution bag at one end and to an interface on the second blood line at the other end, so as to allow the calcium solution to flow into the second blood circuit.

[0250] To facilitate flow control, in some embodiments, the blood component analysis component can process the detection signal of the blood sample to obtain a detection result and output the detection result to the controller of the blood purification equipment. Specifically, the blood component analysis component 300 processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller. That is, after the blood component analysis component 300 detects the blood sample and obtains a detection signal, it further processes the detection signal to obtain a detection result (e.g., a specific concentration value), and the detection result is transmitted by the blood component analysis component 300 to the controller.

[0251] Alternatively, the blood component analysis component outputs the detection signal of the blood sample to the controller of the blood purification equipment, whereby the controller processes the detection signal to obtain the detection result. That is, after the blood component analysis component 300 detects the blood sample and obtains the detection signal, it transmits the detection signal to the controller, which processes the signal to obtain the detection result (e.g., a specific concentration value). The process of obtaining the detection result from the detection signal involves corresponding logical operations; in this embodiment, these logical operations are implemented by the controller. The controller can be the main control board in the blood purification equipment, and the unit implementing the aforementioned logical operations can be integrated into the main control board.

[0252] The controller can issue a flow control signal to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or the flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line based on the detection results; or, the controller can provide flow rate adjustment suggestions for the anticoagulant solution flowing into the first blood line and / or the calcium solution flowing into the second blood line based on the detection results.

[0253] That is, the controller can perform corresponding processing on the blood purification equipment based on the detection results. This processing may include controlling or providing adjustment suggestions for the flow rates of the anticoagulant solution and the calcium solution.

[0254] Taking the aforementioned external power equipment as an example, which includes a first supplementary pump that allows the anticoagulant solution to flow into the first blood line and / or a second supplementary pump that allows the calcium solution to flow into the second blood line, the corresponding processing may include controlling and regulating the flow rate of the anticoagulant solution and the flow rate of the calcium solution.

[0255] The controller sends a control signal to regulate the flow rate of the anticoagulant solution into the first blood tubing, which can control the regulation and operation of the first replenishment pump to avoid adverse effects caused by the concentration of blood components (including the anticoagulant solution) not reaching the standard value. Similarly, the controller sends a control signal to regulate the flow rate of the calcium solution into the second blood tubing, which can control the regulation and operation of the second replenishment pump to avoid adverse effects caused by the concentration of blood components (including the calcium solution) not reaching the standard value.

[0256] Alternatively, the flow control signal can be transmitted to other equipment for the operator to obtain, and then the operator can control the first supplementary pump and / or the second supplementary pump accordingly.

[0257] The controller provides flow rate adjustment suggestions for the anticoagulant solution flowing into the first blood line and / or the calcium solution flowing into the second blood line based on the detection results. These suggestions can be obtained by the operator (e.g., displayed on a screen or announced via a voice device). The operator can then decide whether to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or the calcium solution flowing into the second blood line.

[0258] Taking the aforementioned external power equipment, which includes a first replenishment pump that allows anticoagulant solution to flow into a first blood line and / or a second replenishment pump that allows calcium solution to flow into a second blood line, as an example, the operator may decide whether to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or the calcium solution flowing into the second blood line by adjusting the first replenishment pump and / or the second replenishment pump accordingly.

[0259] like Figure 4 As shown, this embodiment of the invention also provides a medical system having the blood purification device as described above, and an auxiliary power device 500. The auxiliary power device 500 includes a first replenishment pump 510 for flowing anticoagulant solution into a first blood line and / or a second replenishment pump 520 for flowing calcium solution into a second blood line. The first replenishment pump 510 and / or the second replenishment pump 520 are power components independent of the blood purification device.

[0260] In some embodiments, the auxiliary power unit 500 is communicatively connected to the blood purification device. This includes wired and wireless connections. This allows the blood purification device to communicate with the first supplementary pump 510 and / or the second supplementary pump 520 in the auxiliary power unit 500, enabling the start / stop of the first supplementary pump 510 and / or the second supplementary pump 520 and the infusion flow rate to be controlled according to the blood purification device.

[0261] The blood purification device may also include an interactive component, which includes a display screen for displaying the delivery flow rate of the first supplemental pump 510 and / or the second supplemental pump 520.

[0262] The blood component analysis component can also process the detection signal of the blood sample to obtain the detection result and output the detection result to the controller of the blood purification equipment; or, the blood component analysis component can output the detection signal of the blood sample to the controller of the blood purification equipment so that the controller can process the detection signal to obtain the detection result; the controller can adjust the flow rate of the first replenishment pump 510 and / or the second replenishment pump 520 according to the detection result; or, the controller can provide adjustment suggestions for the first replenishment pump 510 and / or the second replenishment pump 520 according to the detection result.

[0263] In other embodiments, the auxiliary power unit 500 is relatively independent of the blood purification equipment. That is, the auxiliary power unit 500 and the blood purification equipment can be placed relatively independently to improve the layout flexibility of the medical system.

[0264] This allows the blood component analysis component to process the detection signal of the blood sample, obtain the detection result, and output the detection result to the controller of the blood purification equipment; alternatively, the blood component analysis component can output the detection signal of the blood sample to the controller of the blood purification equipment so that the controller can process the detection signal and obtain the detection result.

[0265] Furthermore, the operator adjusts the flow rate of the first supplementary pump 510 and / or the second supplementary pump 520 based on the test results. The test results may include specific concentration values, or indications of excessively high or low concentrations of certain components (such as "Post-filter (venous) free calcium concentration: 0.45 mmol / L (excessive)"), allowing the operator to manually adjust the flow rate of the first supplementary pump 510 and / or the second supplementary pump 520 accordingly. The auxiliary power unit 500 may have a display structure for showing the delivery flow rate of the first supplementary pump 510 and / or the second supplementary pump 520. The display structure may include a first display 511 for the first supplementary pump 510, which displays the delivery flow rate of the first supplementary pump 510, allowing the operator to adjust the delivery flow rate of the first supplementary pump 510 accordingly based on the displayed parameters. The display structure may also include a second display 521 for the second supplementary pump 520. The second display 521 can display the delivery flow rate of the second supplementary pump 520 so that the operator can adjust the delivery flow rate of the second supplementary pump 520 accordingly based on the displayed parameters.

[0266] In other embodiments, the blood purification device includes a housing 100, a blood purifier, a blood tubing assembly, a power assembly, and an electrolyte composition analysis assembly.

[0267] Similarly, the housing 100 can be used to house some of the functional components of the blood purification device. These functional components may include some or all of the components described above, such as the blood purifier, blood tubing assembly, power assembly, and electrolyte composition analysis assembly.

[0268] Taking CRRT equipment as an example, a blood purifier may include a filter for removing water and solutes from the blood.

[0269] The blood tubing assembly includes a first blood tubing connecting the human blood vessel to the inlet of a blood purifier, and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel. Through the first and second blood tubing, blood can circulate outside the human body. The first blood tubing transports blood to be purified from the human blood vessel to the blood purifier, while the second blood tubing transports purified blood from the blood purifier to the human blood vessel. An anticoagulant solution can flow into the first blood tubing, and a calcium solution can flow into the second blood tubing. The flow rate of the anticoagulant solution into the first blood tubing can be controlled by a device (relatively independent of the blood purification equipment). Similarly, the flow rate of the calcium solution into the second blood tubing can be controlled by a device (relatively independent of the blood purification equipment). The system utilizes a two-step process: first, an anticoagulant solution flows into the first blood tubing, ensuring that the solution acts on the blood within that tubing. This prevents the blood from coming into contact with the tubing and filtration structure (such as the dialysis membrane) of the blood purification equipment after leaving the blood vessels, thus preventing clotting and ensuring effective blood purification. Second, a calcium solution flows into the second blood tubing, ensuring that the solution acts on the blood within that tubing. This prevents hypocalcemia or other discomfort caused by calcium ion concentrations outside the blood vessels. The first device for infusing the anticoagulant solution and the second device for infusing the calcium solution can be detachably mounted on the blood purification equipment or installed separately.

[0270] An electrolyte component analysis component is used to detect collected waste liquid samples. The electrolyte component analysis component can be housed within the device housing 100. Specifically, waste liquid samples generated by the blood purification equipment during blood purification operations (such as blood purification treatment) are collected manually or automatically and placed in the corresponding detection position (e.g., detection position 310) so that the electrolyte component analysis component can detect the waste liquid samples. Alternatively, the device housing 100 can have a connecting part, and the electrolyte component analysis component can have a mating part that connects to the connecting part. The electrolyte component analysis component is used to detect collected waste liquid samples.

[0271] The blood purification equipment also includes a sampling component that can collect waste liquid samples from the waste liquid pipeline or waste liquid collection device of the blood purification equipment.

[0272] The blood purification device provided in this embodiment of the invention can detect the waste liquid sample generated during the blood purification operation through an electrolyte component analysis component. This facilitates timely monitoring of the electrolyte concentration of the human body during the corresponding operation of the blood purification device, so as to adjust the corresponding pump in the power component accordingly and facilitate the corresponding adjustment of calcium ions in the blood purification circuit.

[0273] Specifically, the electrolyte composition analysis component can detect one or more of the following concentrations in waste fluid samples: calcium, sodium, potassium, chloride, and magnesium ions. Taking sodium ion concentration as an example, during blood purification treatment, for patients with hypernatremia or hyponatremia, the electrolyte composition analysis component detects the sodium ion concentration in the waste fluid sample to monitor the sodium ion concentration in the blood, enabling timely detection and correction of these conditions. Similarly, during blood purification treatment, for patients with hyperkalemia, hypokalemia, or other electrolyte abnormalities, it is also necessary to regularly monitor the corresponding electrolyte concentrations in the blood.

[0274] During the monitoring of the aforementioned ion concentrations, the blood purification equipment can also issue warnings based on the test results, reminding doctors / nurses to promptly identify and address any issues with the patient. For example, it could provide a warning message such as, "Sodium ion concentration is too high, please take action!" The equipment can also present the concentrations of various ions monitored at different time points in a trend graph format, facilitating doctors / nurses' observation and review of the patient's condition throughout the entire treatment process.

[0275] As shown in the above embodiments, the power component of the blood purification device further includes a first replenishment pump that allows the anticoagulant solution to flow into the first blood line and / or a second replenishment pump that allows the calcium solution to flow into the second blood line. The first replenishment pump can control the flow of the anticoagulant solution into the first blood line, including controlling whether the anticoagulant solution flows into the first blood line and the flow rate of the anticoagulant solution into the first blood line. By allowing the anticoagulant solution to flow into the first blood line through the first replenishment pump, the anticoagulant solution acts on the blood within the first blood line, preventing the blood from coming into contact with the tubing and filtration structure (such as a dialysis membrane) of the blood purification device after flowing out of the blood vessels, thus ensuring effective blood purification. The second replenishment pump can control the flow of the calcium solution into the second blood line, including controlling whether the calcium solution flows into the second blood line and the flow rate of the calcium solution into the second blood line. The second replenishment pump allows the calcium solution to flow into the second blood line, thereby enabling the calcium solution to act on the blood in the second blood line and preventing hypocalcemia or physical discomfort caused by the concentration of calcium ions in the blood not being within the standard range after the blood flows into the human blood vessels.

[0276] Alternatively, the anticoagulant solution can be propelled into the first blood line via an external power source, and the calcium solution can be propelled into the second blood line via an external power source. It is understood that the external power source can be a device relatively independent of the blood purification device provided in this embodiment of the invention; the two can be connected wirelessly or via wired communication, or they can be completely independent without any connection structure.

[0277] Furthermore, the electrolyte component analysis component can also be used to detect collected blood samples. That is, the electrolyte component analysis component can have the functions of the blood component analysis component 300 in the above embodiments. Therefore, the blood purification equipment can also be controlled as described in the above embodiments by combining the detection results of waste liquid samples (i.e., the first detection result) with the detection results of blood samples (i.e., the second detection result). Of course, the blood component analysis component 300 can also be additionally provided, which is relatively independent of the electrolyte component analysis component, and as shown in the above embodiments, the blood component analysis component 300 is used to detect collected blood samples.

[0278] Taking the control of blood purification equipment based on the detection results of waste liquid samples as an example, in some embodiments, to facilitate flow control, the electrolyte component analysis component can process the detection signal of the waste liquid sample, obtain the detection result, and output the detection result to the controller of the blood purification equipment. That is, the electrolyte component analysis component processes the detection signal of the waste liquid sample, obtains the detection result, and outputs the detection result to the controller. Specifically, after the electrolyte component analysis component detects the waste liquid sample and obtains the detection signal, it further processes the detection signal to obtain the detection result (e.g., a specific concentration value), and the detection result is transmitted to the controller by the electrolyte component analysis component.

[0279] Alternatively, the electrolyte component analysis component outputs the detection signal of the waste liquid sample to the controller of the blood purification equipment, whereby the controller processes the detection signal to obtain the detection result. That is, after the electrolyte component analysis component detects the waste liquid sample and obtains the detection signal, it transmits the detection signal to the controller, which processes the signal to obtain the detection result (e.g., a specific concentration value). The process of obtaining the detection result from the detection signal involves corresponding logical operations; in this embodiment, these logical operations are implemented by the controller. The controller can be the main control board in the blood purification equipment, and the unit implementing the aforementioned logical operations can be integrated into the main control board.

[0280] The controller can send a flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line based on the detection results; or, the controller can provide a flow rate adjustment suggestion for the calcium solution flowing into the second blood line based on the detection results.

[0281] That is, the controller can process the blood purification equipment accordingly based on the detection results. This processing may include controlling and adjusting the flow rate of the calcium solution or providing adjustment suggestions.

[0282] Taking the aforementioned external power equipment as an example, which includes a first supplementary pump that allows the anticoagulant solution to flow into the first blood line and / or a second supplementary pump that allows the calcium solution to flow into the second blood line, the corresponding processing includes controlling and regulating the flow rate of the anticoagulant solution and the flow rate of the calcium solution.

[0283] The flow rate of the anticoagulant solution can be controlled and adjusted based on the test results of the blood sample (using an electrolyte component analysis component or an additional blood component analysis component 300). Specific details are as shown in the above embodiments, and no further limitations are imposed here.

[0284] The flow rate of the calcium solution can be controlled by the controller sending a control signal to regulate the flow rate of the calcium solution into the second blood line, which can control the regulation and start / stop of the second supplement pump, so as to avoid adverse effects caused by the concentration of blood components (including calcium solution) not reaching the standard value.

[0285] Alternatively, the flow control signal can be transmitted to other equipment for the operator to obtain, and then the operator can control the second supplementary pump accordingly.

[0286] The controller provides suggestions on adjusting the flow rate of the calcium solution flowing into the second blood line based on the detection results. These suggestions can be obtained by the operator (e.g., displayed on a screen or announced via a voice device), and the operator can then decide whether to adjust the flow rate of the calcium solution flowing into the second blood line.

[0287] Taking the aforementioned external power equipment, including a second replenishment pump that allows calcium solution to flow into the second blood line, as an example, the operator can decide whether to adjust the flow rate of calcium solution flowing into the second blood line by adjusting the second replenishment pump accordingly.

[0288] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0289] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A blood purification apparatus characterized by comprising: include: Equipment housing; Blood purifier; A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that causes an anticoagulant solution to flow into the first blood tubing and / or a second replenishment pump that causes a calcium solution to flow into the second blood tubing; A blood component analysis component is disposed within the housing of the device and is used to detect the collected blood samples.

2. The blood purification apparatus according to claim 1, wherein The blood purification device also includes a controller; The blood component analysis component processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller; alternatively, the blood component analysis component outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain a detection result.

3. The blood purification apparatus according to claim 2, wherein The anticoagulant solution is a citric acid solution, and / or the detection result includes at least the calcium ion concentration in the blood sample.

4. The blood purification apparatus according to claim 1, wherein The blood sample can be collected by an operator from the first blood line, the second blood line, and / or the human blood vessel.

5. The blood purification device as described in claim 4, characterized in that, The blood sample is either a blood sample from the first blood tubing or a blood sample from the human blood vessel; or... The blood sample is the blood sample from the second blood tubing.

6. The blood purification apparatus according to claim 4, wherein The device housing has a first side and a second side facing away from each other, and a third side located between the first side and the second side, wherein the first side faces the operator. The blood component analysis component has a detection position, and the blood sample can be placed at the detection position from outside the device housing. The detection position is located on the first, second, or third side of the device housing.

7. The blood purification apparatus according to claim 6, wherein The device housing has a receiving structure, which corresponds to the detection position; The test card carrying the blood sample can be placed within the receiving structure to place the blood sample at the detection position.

8. The blood purification apparatus of claim 1, wherein, The blood purification device further includes a sampling component that collects the blood sample from the first blood line and / or the second blood line.

9. The blood purification apparatus of claim 8, wherein The sampling component is a sampling needle or a sampling tubing; The sampling tubing or the sampling needle is at least partially located within the device housing.

10. The blood purification device as described in claim 8, characterized in that, The blood sample is the blood sample from the first blood tubing; or, The blood sample is the blood sample from the second blood tubing.

11. The blood purification device as described in claim 2, characterized in that, The controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the detection result; or, The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

12. The blood purification device as described in claim 2, characterized in that, The controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

13. The blood purification device as described in claim 1, characterized in that, The blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration. And / or, the blood component analysis component is capable of detecting one or more of the following values ​​of the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

14. The blood purification device according to any one of claims 1-13, characterized in that, The blood purification device also includes an interactive component, which is communicatively connected to the blood component analysis component and is capable of outputting detection results of at least one ion concentration.

15. The blood purification device as described in claim 14, characterized in that, The interactive component includes a display screen, which is used to display the detection results, adjustment suggestions based on the detection results, and / or prompts indicating that corresponding adjustments have been made based on the detection results; Alternatively, the interactive component may include a voice component, which is used to output the detection result, adjustment suggestions based on the detection result, and / or a prompt indicating that corresponding adjustments have been made based on the detection result.

16. A blood purification device, characterized in that, include: Equipment housing, the equipment housing having a connecting portion; Blood purifier; A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that causes an anticoagulant solution to flow into the first blood tubing and / or a second replenishment pump that causes a calcium solution to flow into the second blood tubing; A blood component analysis component having a mating part connected to the connecting part, the blood component analysis component being used to detect collected blood samples.

17. The blood purification device as described in claim 16, characterized in that, The blood purification device also includes a controller; The blood component analysis component processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller; alternatively, the blood component analysis component outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain a detection result.

18. The blood purification device as described in claim 17, characterized in that, The anticoagulant solution is a citric acid solution, and / or the detection results include at least the detection results of the calcium ion concentration in the blood sample.

19. The blood purification device as described in claim 17, characterized in that, The controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the detection result; or, The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

20. The blood purification device as described in claim 17, characterized in that, The controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

21. The blood purification device as described in claim 16, characterized in that, The connecting part is detachably connected to the mating part.

22. The blood purification device as described in claim 16, characterized in that, The connecting part is a plug-in box with an opening located on the outer wall of the device housing and recessed into the device housing; the mating part is the outer wall of the blood component analysis component. The blood component analysis component can be plugged into the plug-in box.

23. The blood purification device as described in claim 16, characterized in that, The connecting part is located on the outer wall of the device housing, and the mating part is located on the outer wall of the blood component analysis component and can be connected to the connecting part.

24. The blood purification device as described in claim 16, characterized in that, The blood sample can be collected by an operator from the first blood line, the second blood line, and / or the human blood vessel.

25. The blood purification device as described in claim 24, characterized in that, The blood sample is either a blood sample from the first blood tubing or a blood sample from the human blood vessel; or... The blood sample is the blood sample from the second blood tubing.

26. The blood purification device as described in claim 16, characterized in that, The blood component analysis component has a detection position and a receiving structure, wherein the receiving structure corresponds to the detection position; The test card carrying the blood sample can be placed within the receiving structure to place the blood sample at the detection position.

27. The blood purification device as described in claim 16, characterized in that, The blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration. And / or, the blood component analysis component is capable of detecting one or more of the following values ​​in the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

28. The blood purification device according to any one of claims 16-27, characterized in that, The blood purification device also includes an interactive component, which is communicatively connected to the blood component analysis component and is capable of outputting detection results of at least one ion concentration.

29. The blood purification device as described in claim 28, characterized in that, The interactive component includes a display screen, which is used to display the detection results, adjustment suggestions based on the detection results, and / or prompts indicating that corresponding adjustments have been made based on the detection results; Alternatively, the interactive component may include a voice component, which is used to output the detection result, adjustment suggestions based on the detection result, and / or a prompt indicating that corresponding adjustments have been made based on the detection result.

30. A medical system comprising: A blood purification device, comprising a device housing, a blood purifier, a blood tubing assembly, and a power assembly; the blood tubing assembly includes a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; the power assembly includes a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; A blood gas analyzer is used to test blood samples. The blood gas analyzer and the blood purification equipment can be placed relatively independently but are connected in communication.

31. The medical system as described in claim 30, characterized in that, The blood purification device also includes a controller; The blood gas analyzer processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller; alternatively, the blood gas analyzer outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain a detection result.

32. The medical system as described in claim 31, characterized in that, The controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the detection result; or, The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

33. The medical system as described in claim 31, characterized in that, The controller can provide adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

34. The medical system according to any one of claims 30-33, characterized in that, The blood purification equipment and the blood gas analysis equipment are to be installed in the same medical room.

35. The medical system as described in claim 34, characterized in that, The number of blood purification devices is multiple, and the blood gas analysis device is communicatively connected to the multiple blood purification devices. Alternatively, the number of blood purification devices may be one.

36. A blood purification device, characterized in that, include: Equipment housing; Blood purifier; A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly, a first replenishment pump that causes an anticoagulant solution to flow into the first blood tubing and / or a second replenishment pump that causes a calcium solution to flow into the second blood tubing; Controller; A blood component analysis component is used to detect collected blood samples, and the blood component analysis component is communicatively connected to the controller.

37. The blood purification device as described in claim 36, characterized in that, The blood component analysis component processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller; alternatively, the blood component analysis component outputs the detection signal of the blood sample to the controller so that the controller processes the detection signal to obtain a detection result.

38. The blood purification device as described in claim 36, characterized in that, The controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the detection result; or, The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

39. The blood purification device as described in claim 36, characterized in that, The controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump based on the detection results.

40. The blood purification device as described in claim 36, characterized in that, The blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration. And / or, the blood component analysis component is capable of detecting one or more of the following values ​​of the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

41. The blood purification device as described in claim 40, characterized in that, The blood sample can be collected by an operator from the first blood line, the second blood line, and / or the human blood vessel.

42. The blood purification device according to any one of claims 36-41, characterized in that, The blood purification device also includes an interactive component, which is communicatively connected to the blood component analysis component and is capable of outputting detection results of at least one ion concentration.

43. The blood purification device as described in claim 42, characterized in that, The interactive component includes a display screen, which is used to display the detection results, adjustment suggestions based on the detection results, and / or prompts indicating that corresponding adjustments have been made based on the detection results; Alternatively, the interactive component may include a voice component, which is used to output the detection result, adjustment suggestions based on the detection result, and / or a prompt indicating that corresponding adjustments have been made based on the detection result.

44. A blood purification device, characterized in that, include: Equipment housing; Blood purifier; A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing; A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly; A blood component analysis component is disposed within the housing of the device and is used to detect the collected blood samples.

45. A blood purification device, characterized in that, include: Equipment housing, the equipment housing having a connecting portion; Blood purifier; A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing; A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly; A blood component analysis component having a mating part connected to the connecting part, the blood component analysis component being used to detect collected blood samples.

46. ​​The blood purification device as described in claim 44 or 45, characterized in that, The blood component analysis component can detect one or more of the following concentrations in the blood sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration. And / or, the blood component analysis component is capable of detecting one or more of the following values ​​of the blood sample: pH, pCO2, pO2, Glu, Lac, and Hct.

47. The blood purification device as described in claim 44 or 45, characterized in that, The anticoagulant solution flows into the first blood line via an external power device, and the calcium solution flows into the second blood line via an external power device.

48. The blood purification device as described in claim 44 or 45, characterized in that, The blood component analysis component processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller of the blood purification device; or, the blood component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain the detection result. The controller can issue a flow control signal to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or the flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line based on the detection results; or, the controller can provide flow rate adjustment suggestions for the anticoagulant solution flowing into the first blood line and / or the calcium solution flowing into the second blood line based on the detection results.

49. A medical system comprising: Blood purification equipment, wherein the blood purification equipment is the blood purification equipment as described in claim 44 or 45; An auxiliary power device, comprising a first replenishment pump that allows anticoagulant solution to flow into the first blood line and / or a second replenishment pump that allows calcium solution to flow into the second blood line.

50. The medical system as described in claim 49, characterized in that, The auxiliary power equipment is communicatively connected to the blood purification equipment; The blood purification device further includes an interactive component, which includes a display screen for displaying the delivery flow rate of the first supplemental pump and / or the second supplemental pump. And / or, the blood component analysis component processes the detection signal of the blood sample to obtain a detection result and outputs the detection result to the controller of the blood purification device; or, the blood component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain a detection result; the controller adjusts the flow rate of the first supplementary pump and / or the second supplementary pump according to the detection result; or, the controller provides adjustment suggestions for the first supplementary pump and / or the second supplementary pump according to the detection result.

51. The medical system as described in claim 49, characterized in that, The auxiliary power equipment is relatively independent of the blood purification equipment; The blood component analysis component processes the detection signal of the blood sample to obtain the detection result and outputs the detection result to the controller of the blood purification device; or, the blood component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain the detection result. The operator adjusts the flow rate of the first supplementary pump and / or the second supplementary pump based on the test results.

52. The medical system as described in claim 51, characterized in that, The auxiliary power equipment has a display structure for displaying the delivery flow rate of the first supplementary pump and / or the second supplementary pump.

53. A blood purification device, characterized in that, include: Equipment housing; Blood purifier; A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing; A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly; An electrolyte component analysis component is installed inside the device housing. The electrolyte component analysis component is used to detect waste liquid samples generated during blood purification operations.

54. A blood purification device, characterized in that, include: Equipment housing, the equipment housing having a connecting portion; Blood purifier; A blood tubing assembly, comprising a first blood tubing connecting a human blood vessel to the inlet of a blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel, wherein an anticoagulant solution can flow into the first blood tubing and a calcium solution can flow into the second blood tubing; A power assembly, the power assembly including a blood pump that drives blood to flow within the blood tubing assembly; An electrolyte component analysis component has a mating part that connects to the connecting part, and the electrolyte component analysis component is used to detect and collect waste liquid samples generated during blood purification operations.

55. The blood purification device as described in claim 53 or 54, characterized in that, The electrolyte composition analysis component can detect one or more of the following concentrations in the waste liquid sample: calcium ion concentration, sodium ion concentration, potassium ion concentration, chloride ion concentration, and magnesium ion concentration.

56. The blood purification device as described in claim 53 or 54, characterized in that, The power assembly also includes a first replenishment pump that allows the anticoagulant solution to flow into the first blood line and / or a second replenishment pump that allows the calcium solution to flow into the second blood line.

57. The blood purification device as described in claim 53 or 54, characterized in that, The anticoagulant solution flows into the first blood line via an external power device, and the calcium solution flows into the second blood line via an external power device. And / or, the blood purification device further includes a sampling component capable of collecting waste liquid samples from the waste liquid pipeline or waste liquid collection device of the blood purification device.

58. The blood purification device as described in claim 53 or 54, characterized in that, The electrolyte component analysis component processes the detection signal of the waste liquid sample to obtain a first detection result and outputs the first detection result to the controller of the blood purification device; or, the electrolyte component analysis component outputs the detection signal of the waste liquid sample to the controller of the blood purification device so that the controller processes the detection signal to obtain the first detection result. The controller can issue a flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line based on the first detection result; or, the controller can provide a flow rate adjustment suggestion for the calcium solution flowing into the second blood line based on the first detection result.

59. The blood purification device as described in claim 53 or 54, characterized in that, The electrolyte composition analysis component is also used to detect collected blood samples.

60. The blood purification device as described in claim 59, characterized in that, The electrolyte component analysis component processes the detection signal of the blood sample to obtain a second detection result and outputs the second detection result to the controller of the blood purification device; or, the electrolyte component analysis component outputs the detection signal of the blood sample to the controller of the blood purification device so that the controller processes the detection signal to obtain a second detection result. Based on the second detection result, the controller can issue a flow control signal to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or a flow control signal to adjust the flow rate of the calcium solution flowing into the second blood line; or, based on the second detection result, the controller can provide a flow control signal to adjust the flow rate of the anticoagulant solution flowing into the first blood line and / or a flow rate adjustment suggestion for the calcium solution flowing into the second blood line.

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