Absorbable intravascular stent and preparation method thereof

Abstract

The invention belongs to the technical field of medical apparatus and instruments, and particularly relates to an absorbable intravascular stent and a preparation method thereof. The absorbable intravascular stent comprises a net-shaped degradable metal stent body and a degradable polymer coating which is arranged on the surface of netting wires of the net-shaped degradable metal stent body; and the component of the degradable polymer coating is polylactic acid-hydroxyacetic acid copolymer. The degradation time of the absorbable intravascular stent can be correspondingly regulated and controlled by adjustment of the components of a stent structure and the component of the degradable polymer coating, the components can be degraded and discharged out of the body, the shortest period of degradation and discharging is within 1-2 months, the longest period of degradation and discharging can be 12 months, the degradation time can be adjusted according to specific conditions, the circumstances that foreign body sensation is caused by existing of the stent after the task of the stent is finished, and vascular injury is caused by the stent are avoided, and meanwhile, a series of problems ofcoating, displacement and the like which are caused by stimulation on an immune system due to the unnecessary stent are further avoided.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to an absorbable vascular stent and a preparation method thereof. Background technique [0002] Since Sigwart first applied coronary stent implantation in clinical practice in 1987, the development of vascular stents has gone through three stages: bare metal stents, drug-eluting stents and fully bioabsorbable stents. The first generation of bare stents has a high rate of restenosis; although the efficacy of the second generation of drug-carrying stents has been proven, the long-term existence of non-degradable metal stents and the problem of carrying drugs to inhibit endothelial growth can lead to long-term angiogenesis. embolism. [0003] Fully bioabsorbable stents include metal stents and polymer stents, the latter receiving more attention. Polymer stents have better compatibility with the vessel wall than metal stents, which can avoid late intimal proliferation, especia...

AI Technical Summary

Problems solved by technology

The vascular stent made of this kind of polymer material can maintain a certain mechanical strength and keep the blood vessel unblocked during the healing period of the vascular injury. Resonance or magnetic therapy and other examinations; however, the radial support force of the stent made of this kind of polymer material is relatively poor, the probability of reoccurrence of thrombus in the stent is high, chronic inflammation is easy to occur, the rate of vascular endothelial hyperplasia is relatively high, and it is easy to occur during the degradation process. Mass, which again blocks blood vessels

[0006] At present, the interventional stent method has achieved good results in the treatment of cardiovascular diseases, and the preparation technology of the stent is also very mature. However, restenosis will occur after implantation of the simple degradable polymer stent, which may be caused by the stent in vivo. Therefore, it is urgent to provide a stent that can provide sufficient radial support force, controllable degradation time and low recurrence rate of thrombosis in the later stage during vascular reconstruction.

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