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Implanting type degradable device for promoting nerve regeneration after ambient nerve implanting

A peripheral nerve and nerve regeneration technology, applied in medical science, prosthesis, etc., can solve the problems of long clinical application distance, complicated production, limited application, etc., and is conducive to large-scale production and clinical promotion and use, axon Stretching and directional growth promotion, the effect of simple means to achieve

Inactive Publication Date: 2012-12-26
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this type of cell-based tissue engineering is still far from clinical application.
Adding various neurotrophic factors to scaffold materials through chemical or biological technical methods, on the one hand, has high technical requirements, complicated production, and it is difficult to ensure the activity of neurotrophic factors, and it is difficult to standardize and stabilize production. On the other hand, most of them can only add a small amount A single neurotrophic factor has a very limited effect on promoting nerve regeneration, so that its application is limited; therefore, how to contain multiple neurotrophic factors in the existing peripheral nerve graft materials has become a research hotspot

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Preparation of the implantable degradable device for promoting nerve regeneration after peripheral nerve transplantation according to the present invention

[0022] Prepare the material using poly(lactic-co-glycolic acid) (PLGA).

[0023]Preparation of semi-cylindrical components: use poly(lactic acid-glycolic acid) copolymer (PLGA) (molar ratio GA:LA=20:80) as raw material, dissolve it in dichloromethane, add particle size 200-300 microns NaCl was used as a porogen (the mass ratio of PLGA to NaCl was 1:9), and lysine was added as an alkaline regulator in a proportion of 5%, and mixed evenly, and the mixture was formed into a film in a special mold. The mixture in the mold evaporated naturally in a fume hood at room temperature. After 96 hours, demould, take out the semi-columnar stent, move it to a vacuum drying oven, and dry it under vacuum at 37° C. for 48 hours. Immerse the semi-columnar material in a large 800ml beaker filled with deionized water, c...

Embodiment 2

[0025] Example 2: Preparation of the implantable degradable device for promoting nerve regeneration after peripheral nerve transplantation according to the present invention

[0026] The preparation material is chitosan.

[0027] Preparation of semi-cylindrical components: 350 mg of chitosan was dissolved in 10 ml of 3 mg / ml acetic acid solution, vacuumed and left standing for 12 h, and the chitosan solution was injected into a special mold. Slowly immerse the injection molded sample in the deep low temperature cold shower (liquid nitrogen) along the axial direction, and carry out gradient cold shower. Cut the 10 cm long silicone tube frozen body of collagen-chitosan suspension into 2.0 cm short sections, place them in a pre-cooled aluminum tray, put them into an Alphal-2 freeze dryer, and store them at -60 °C, Freeze-dried at 100 m torr for 24 h. In the vacuum environment of the freeze dryer, the solvent ice crystals in the cryostand sublimate, resulting in components with ...

Embodiment 3

[0029] Example 3: Preparation of the Implantable Degradable Device for Promoting Nerve Regeneration After Peripheral Nerve Transplantation According to the Present Invention

[0030] The preparation material is collagen.

[0031] Preparation of semi-cylindrical components: Weigh 150mg of collagen and dissolve it in 0.05mmol / L glacial acetic acid solution, stir for 90min (18000r / min) at 4°C, vacuumize under negative pressure and put it in a refrigerator at 4°C overnight, and mix thoroughly to form a coagulate After injecting the colloidal suspension into a special mold, and forming it with 2×10 -5 After entering the condensing agent at a speed of m / s, put it into a pre-cooled aluminum tray, and freeze-dry it at -40°C and 100mtorr for 48h to obtain a dry-formed collagen assembly.

[0032] Assembly and use of components: Assembly and use of components: The prepared semi-cylindrical components are loaded with substances that promote nerve regeneration, such as jelly-like glial-de...

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Abstract

The invention relates to an implanting type degradable device for promoting nerve regeneration after ambient nerve implanting. The implanting type degradable device comprises a hollow cylindrical device which is formed by jointing two symmetric semi-cylindrical subassemblies, wherein the cylindrical device is internally divided into a plurality of independent small chambers for loading nerve regeneration promoting materials with different concentrations; the two ends of the cylindrical device are opened, the ambient nerve for implanting repairing material can pass through one end of the cylindrical device, and pass out through the other end of the cylindrical device; a clearance between the two semi-cylindrical subassemblies can be sealed to form a closed tubular structure through medical bioprotein; and the semi-cylindrical subassemblies are manufactured by degradable biocompatibility materials. The implanting type degradable device has the characteristics of simplicity, convenience, safety and high efficiency; the implanting type degradable device can be used for loading various nerve regeneration promoting materials, and driving the nerve regeneration promoting materials to move around the ambient nerve implants by forming a concentration gradient based on the remote end and the near end of the nerve, so that a microenvironment beneficial to the regeneration of the ambient nerve axon can be formed.

Description

technical field [0001] The invention relates to providing an implantable device for promoting nerve regeneration after peripheral nerve transplantation, especially a degradable device for promoting nerve regeneration after peripheral nerve transplantation. Background technique [0002] The repair and functional reconstruction of peripheral nerve defects has been a major problem in the world's clinical medical research for more than a hundred years. With the rapid development of social economy, the degree of mechanization increases, the traffic is increasingly developed, and the population flow is doubled, the damage of peripheral nerves is rising rapidly. Peripheral nerve injuries are common in young and middle-aged labor force. The disability of labor force has become a heavy economic and ethical burden for social development and family, restricting and hindering the development of social economy. [0003] The treatment effect of peripheral nerve injury is unsatisfactory. ...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/38A61L27/54
Inventor 刘小林朱庆棠郑灿镔
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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