Injectable hydrogel for treating central nervous injury and preparation method thereof

Abstract

The invention provides in-situ injectable hydrogel for treating central nervous injury and a preparation method of the in-situ injectable hydrogel. The hydrogel is formed by performing click chemical coupling on X-Y through functional groups on arginine-glycine-aspartic acid modified multi-arm polyethylene glycol-X and multi-arm polyethylene glycol-Y, nano / micron particles and growth factors of slow-release immunoregulation and / or antioxidant drugs loaded on the hydrogel through chemical coupling reaction are coated in the hydrogel. The injection hydrogel disclosed by the invention can be used for precisely and slowly releasing the immunomodulatory and / or antioxidant drug and the growth factor locally at an injured part, so that the formation of a cystic cavity after spinal cord injury is prevented, secondary injury caused by neuroinflammation is relieved, residual spinal cord nervous tissues and axons are protected, and the formation of glial scar tissues is reduced; a penetrable extracellular matrix environment is provided for regeneration of body nerve axons, further recovery of electrophysiology and motor functions is promoted, and the method can be used for repairing injury of soft tissues such as spinal cords and the like.

Description

technical field [0001] The invention relates to the technical field of soft tissue repair engineering, in particular to the preparation and application of an injectable hydrogel for treating spinal cord injuries. Background technique [0002] Spinal cord injury (SCI) is a severely disabling disease that often results in severe physiological dysfunction of the limbs below the level of injury. According to statistical analysis, the annual incidence of SCI worldwide is 40-50 per million people. At present, more than 27 million patients in the world suffer from sequelae such as paralysis, of which there are about 4 million patients in China, and the annual rate is about 120,000. speed increase. [0003] The severe neuroinflammation response caused by SCI will induce the apoptosis of neurons at the injury site to produce toxic cell residues, and then destroy the undamaged spinal cord tissue near the lesion, and these pathological changes will eventually destroy the neural circui...

AI Technical Summary

Problems solved by technology

Despite the great potential of these biomaterials, the clinical success of these biomaterials has been very limited, mainly because the spatiotemporal characteristics of the neuroinflammatory microenvironment in the process of SCI tissue healing have not been comprehensively considered, and the immune microenvironment caused by SCI has not been precisely adjusted. out of balance

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