Purpose of curcumin or drug-loading system thereof in preparation of drug for treating penis erection dysfunction

A technology for erectile dysfunction and curcumin, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., to achieve good biocompatibility, non-toxic biocompatibility, and improve bioavailability

Pending Publication Date: 2021-01-22
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no report on the use of curcumin to repair cavernous nerve damage or to treat penile erectile dysfunction

Method used

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  • Purpose of curcumin or drug-loading system thereof in preparation of drug for treating penis erection dysfunction
  • Purpose of curcumin or drug-loading system thereof in preparation of drug for treating penis erection dysfunction
  • Purpose of curcumin or drug-loading system thereof in preparation of drug for treating penis erection dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: the preparation of curcumin sustained release drug film

[0055] Accurately weigh 3.5mg of curcumin and dissolve it in 3ml of ethyl acetate, continue to add 996.5mg of PLGA-PEG, stir at room temperature for 30min to fully dissolve. After the above solution was left to stand at room temperature for 10 minutes, it was spread in a glass mold cavity by casting method, and ventilated and dried for 24 hours at room temperature to form a film. After the solvent evaporates, a curcumin slow-release drug film with a thickness of 0.5 mm is formed, and the mass fraction of curcumin is 0.35%.

Embodiment 2

[0056] Embodiment 2: the preparation of curcumin sustained release drug film

[0057] Adopt the method identical with embodiment 1, difference only is that the quality of controlling curcumin is 7.0mg, and the quality of PLGA-PEG is 993.0mg, and the massfraction that makes curcumin is the curcumin sustained release drug film of 0.70%.

Embodiment 3

[0058] Embodiment 3: the preparation of curcumin sustained release drug film

[0059] Adopt the method identical with embodiment 1, difference only is that the quality of controlling curcumin is 14.0mg, and the quality of PLGA-PEG is 986.0mg, and the massfraction that makes curcumin is 1.40% curcumin slow-release drug film.

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Abstract

The invention discloses a purpose of curcumin or a drug-loading system thereof in preparation of the drug for treating penis erection dysfunction. An experiment proves that the curcumin and a curcuminslow release drug film can up-regulate the expression of GAP-43 and MAP-2 to accelerate growth of the nerve axon and can up-regulate the expression of Oct-6 and Krox-20 to accelerate Schwann cells tosynthesize and secrete myelin sheath-associated protein so as to accelerate formation of the nerve axon myelin sheath. Meanwhile, repair and regeneration after a rat suffers from cavernous body nerveinjury, neural pathway continuity of the cavernous body is recovered, and expression of penis tissue nerve terminal nNOS mRNA and protein is increased. The penis erection function of the rat who suffers from the cavernous body nerve injury can be further improved, meanwhile, a penis tissue fibrosis degree is lowered, and rehabilitation of the penis after the cavernous body nerve injury is effectively accelerated. Therefore, the curcumin and the drug-loading system thereof perform a good application prospect in the preparation of the drug for treating the penis erection dysfunction and repairing the cavernous body nerve injury.

Description

technical field [0001] The invention belongs to the field of pharmacy, and specifically relates to the use of curcumin or its drug-carrying system in the preparation of medicines for treating penile erectile dysfunction. Background technique [0002] Neurogenic erectile dysfunction is a common type of adult male erectile dysfunction (erectiledysfunction, ED), accounting for about 10% to 19% of all ED. Cavernous nerve injury is one of the root causes of neurogenic erectile dysfunction, and ED caused by cavernous nerve injury is a common complication in pelvic and urethral surgery. In recent years, with the development of medical technology, male pelvic tumor surgery , pelvic radiotherapy and transurethral surgery and other surgeries, more and more patients with cavernous nerve injury. At present, the clinical treatment of ED caused by cavernous nerve injury is very difficult, and it is one of the research hotspots and difficulties in the field of urology and andrology. The c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K9/70A61K47/34A61P15/10
CPCA61K9/7007A61K31/12A61K47/34A61P15/10
Inventor 董强任正举杨璐辰柳良仁彭珠峰方琨杨博刘正欢宋攀
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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