71 results about "Central veins" patented technology

An intro-aortic balloon catheter system and method for determining cardiac output with the system including a distal end for insertion into an aorta and a proximal end opposed to the distal end, a balloon portion in proximity to the distal end which repeatedly expands and contracts so as to assist the pumping action of the heart, a catheter tube connected to the balloon portion with the catheter tube having a lumen introducing a pressurized gas into the balloon portion and leading the pressurized gas out from the balloon portion and a temperature sensor attached to the catheter tube and being electrically coupled to a connector at the proximal end of the catheter tube. The method includes inserting the temperature sensor into a lumen of the intra aortic balloon catheter system, advancing the temperature sensor until it projects freely into the aorta, injecting an injectate of a temperature different to that of the temperature of the patient's blood into the central vein of the patient, measuring the blood temperature profile versus time by means of the temperature sensor and calculating cardiac output and optionally the derived variables from the measured temperature profile.

A fan blade has a three dimensional shape that resembles a leaf. The blade is made of balsa or other suitable wood with the grain of the wood running along its length. The obverse surface of the blade is contoured and has a central vein and lateral veins running from the central vein to opposite edges. The reverse side has one or more channels. Braces are set in the channels. The braces are also made of balsa or comparable wood and their grain runs transverse to the direction of the gain of the blade.

The invention relates to methods of transvascular retrograde access placement into a central blood vessel and to devices that facilitate these methods. The method includes positioning a vascular catheter within the vessel such that its distal end faces a desired exit site on the vessel wall, passing a penetrating device from the catheter through the vascular exit site and skin of the patient; and passing a secondary vascular catheter through the exit site and into the central blood vessel. In another aspect, the method includes penetrating outward from within the vessel to form a pass-through site on a wall of the vessel that exits the patient; and placing the vascular access device into the vessel through the pass-through site. Typical vessels that may be accessed include central veins, but may include other veins as well as arteries. Devices that facilitate the method include a stiff intravascular guidewire with a distally-mounted penetrating device such as a needle, and a two-channel vascular catheter with an angled tip.

The invention encompasses methods for selectively enriching in rare particles from blood samples harvested from the vein jugular vein the femoral vein, the subclavian vein, or an artery. These rare particles can be circulating tumor cells, circulating stem cells, or fragments thereof. Blood samples harvested from different sources can contain higher or lower concentrations of rare particles. The rare particles can be enriched by applying the blood samples to a microfluidic device with a two dimensional array of obstacles.

Plasma fluid removal is needed in a variety of clinical conditions including congestive heart failure and moderate renal insufficiency. In order to avoid the problems inherent in extracorporeal ultrafiltration methods, the present invention removes fluid using an intravascular or intracorporeal dual-lumen catheter. Plasma fluid is driven across a semipermeable membrane, as in an in vivo vascular catheter. Suboptimal intracatheter flow, luminal collapse, erratic high transmembrane flow with nonhomogenous caking and clotting of the external catheter surface are all avoided by inducing pressure gradients across the wall by means of osmotic forces instead of negative pressures induced by hydraulic pumps. Osmotically induced fluid flow would tend to keep the lumena slightly distended and thereby simplify the fluid delivery systems. Osmotic gradients are maintained by utilizing dual lumen catheters typically placed in large central veins, and attached to pumps supplying high osmolality sterile solutions (such as dextrose or other sugars). Such a sealed system using readily available sterile sugar solutions and biocompatible catheter substrate would be extremely safe.

The central venous sensor assembly comprises a catheter body with several proximal ports. The catheter portion placed in the vena cava superior is equipped with a proximal flux measurement unit, and the catheter portion placed in the vena cava inferior is equipped with a distal flux measurement unit. A first input channel supplies a measurement signal indicative of a flux vp to the evaluation unit from which the latter calculates a blood flow in the vena cava superior. Likewise, a second input channel supplies a measurement signal indicative of a flux vd to the evaluation unit from which the latter calculates a blood flow rate in the vena cava inferior. Due to continuity, the sum of the flow rates in the upper and lower central veins corresponds to the flow rate through the right heart and in the pulmonary artery and thus to cardiac output.

The invention belongs to the medical teaching equipment technical field and relates to a fully-automatic multi-functional integrated puncture training computer dummy. The fully-automatic multi-functional integrated puncture training computer dummy comprises a high-simulation human body model, a position-automatic changing experimental table, puncture cavities, modules, arteriovenous veins, a liquid injection automatic control device, a fully-automatic arterial pulse simulator and a microcomputer controller. The dummy is characterized in that the high-simulation human body model is installed on the position-automatic changing position experimental table and is provided with various puncture cavities / modules such as pneumothorax, hydrothorax and abdominocentesis modules which are all connected with the microcomputer controller and / or a micro water pump / air pump; double-layer metal mesh electrodes are distributed on the neck, thoracic puncture and lumbar puncture positions of the dummy; the dummy is further provided with kidney, bladder, lymph gland and bone marrow puncture cavities / modules as well as a variety of puncturable central veins and peripheral veins; and arteries are connected with a fully-automatic blood circulation simulator. With the dummy adopted, dozens of puncture items can be provided; puncture position change, liquid injection, gas injection and artery pulsing are completely automated; and sound-light alarms can be given out automatically; life-like simulation effects can be realized; and teaching effects can be significantly improved.

A synergistic medical composition for preventing and treating diabetes and its complication, senile dementia, cardiovascular and cerebrovascular diseases, the thrombosis of central vein of retina, hyperlipemia, fatty liver, etc. features that it contains the extract(s) of natural plant(s).

The present invention comprises methods and apparatuses that can provide accurate measurement of glucose or other analytes from a multilumen catheter in the presence of infusion of substances, including glucose. Examples of “multilumen catheters” include central venous catheters having multiple lumens, midline catheters having multiple lumens, multiple catheters configured or emplaced such that their lumens are in proximity to each other, and, in the case of indwelling analyte sensors, a catheter with a lumen for infusion and an indwelling sensor spaced apart from the infusion lumen. For blood withdrawal, anti-cross contamination controls can prevent the entrainment of blood which might be contaminated with feeding fluids or medications that are administered through other lumens within the catheter and in proximity of the blood sampling port. Cross contamination can occur under various situations, and is known to occur when the patient is connected to a ventilator. The ventilator cyclically raises the intra-thoracic pressure and diminishes blood flow rate in the central veins returning to the heart. The diminished flow can increase the chances for cross-contamination when additional lumens are introducing fluids during a draw sample.

The invention relates to an intravascular mild hypothermia therapy device which comprises a normal saline storage box, a first pipeline, an electronic refrigerator, a second pipeline, a central venous catheter and a third pipeline. The normal saline storage box and the electronic refrigerator are communicated through the first pipeline. The electronic refrigerator and the central venous catheter are communicated through the second pipeline. The central venous catheter and the normal saline storage box are communicated through the third pipeline. A pushing pump is arranged on the second pipeline. The liquid inlet end of a honeycomb meshed heat exchange pipe inside the electronic refrigerator is communicated with the first pipeline, and the liquid outlet end of the honeycomb meshed heat exchange pipe is communicated with the second pipeline. Normal saline inside the normal saline storage box is conveyed by the pushing pump into the honeycomb meshed heat exchange pipe and then cooled by an electronic refrigeration sheet into low-temperature normal saline, one end of the central venous catheter enters a lower plenum central vein from a human body femoral vein puncture opening, a temperature difference between the circularly-flowing normal saline and blood inside the central venous blood vessel, and heat exchange between the surface of the central venous blood vessel and the blood in the patient blood vessel is performed.

Featured is a device for puncturing tissue of a body, such as the lamina cribosa and methods for treating a CVRO with such a puncturing device. The puncturing device includes a puncture member being generally configured and arranged to locally disrupt tissue proximal an area of the puncture site, to minimize the potential for damage to body parts or tissue immediately adjacent to this area of the puncture site and to facilitate perforation of the tissue at the puncture site. When the lamina cribosa is being punctured, the puncture member is more particularly configured and arranged to locally disrupt connective tissue of the lamina cribosa proximal to and surrounding the central retinal vein while minimizing the potential for structural damage to the central retinal vein. In an exemplary embodiment, the lamina cribosa is repeatedly punctured to strip / locally disrupt connective tissue surrounding the central retinal vein.

Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava. The TDPS can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance / support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.

The invention provides an in-vivo enrichment device for circulating tumor cells. The in-vivo enrichment device comprises a catheter body capable of puncturing to a central vein through a peripheral vein, a plurality of sieve holes are formed in the catheter wall of the catheter body, the catheter body is filled with trapped particles of targeting circulating tumor cells, and a blind end is arranged at the front end of the catheter body. According to the in-vivo enrichment device for the circulating tumor cells, the inside of the catheter body is filled with assembling hydrophilic medicine or trapped particles of a specific antibody, the sieve holes are formed in the pipe wall of the catheter body, CTC in blood is continuously combined on the trapped particles inside the catheter body through specific targeting accordingly, and efficient and high-quality trapping of the CTC in blood is achieved; the in-vivo enrichment device has the advantages that the enrichment device is used in vivo, efficient trapping is achieved, and clinical application is convenient; the in-vivo enrichment device can provide molecular-gene diagnosis information based on the CTC for early diagnosis, targeting therapy, recurrence and metastasis detection, treatment evaluation and the like of tumor, and has quite-broad application prospects.

The invention relates to the field of photo-electrochemical detection, and especially relates to an application of parameters in SHG / TPEF images as hepatic fibrosis staging characteristic parameters of adults or children. Images of nonchromosomal tissues obtained from liver puncture of adults and children are formed by means of an SHG / TPEF technology, and fibrosis characteristic parameters of a central vein area / portal area / perisinusoidal area are extracted by means of a digital image processing technology. Whether a sample is an adult or child is distinguished by means of four parameters (thenumber of crosslinking points in the portal area, the percentage of accumulative collagen in the portal area, the number of accumulative long tracts in the central vein area or the number of discretethick tracts in the central vein area). Fibrosis evaluation is carried out by means of six fibrosis characteristic parameters (the fiber tract length, the fiber tract width, the fiber tract eccentricity, the fiber tract toughness, the number of fiber tracts in the portal area and the number of short fiber tracts in the portal area), and the NASH CRN stages of adults and children can be effectively distinguished.

The invention discloses an optical non-invasive detection method for oxygen saturation of mixed venous blood and oxygen saturation of central venous blood. Infrared light is adopted, an absorption spectrum of reflected light is measured, and specific mixed and central vein calculation methods are provided. Compared with existing testing methods for blood oxygen saturation, the optical non-invasive detection method not only achieves non-invasive detection but also can achieve real-time continuous monitoring. The specific algorithms are simple, effective and easy to achieve. During measurement, any part of a human body does not need to be clamped, only the body surface needs to be attached to, then the purpose can be achieved by measuring the absorption spectrum of the reflected light, a patient feels more comfortable during measurement, and measurement is simpler and more convenient. Besides, when the oxygen saturation of central venous blood is measured, jugular veins and subclavian veins are preferably selected for a target deep-layer vascular structure, and measurement is more accurate.

In emergency, the optimal method for building an emergency transfusion channel is intra-bone marrow transfusion which ensures that a medicament and liquid transfused into the marrow cavity can quickly and effectively enter blood circulation. The time for the medicament administrated from intra-bone marrow to enter systemic circulation is basically the same as that for the medicament which is administrated from central veins to enter the systemic circulation, but is quicker than that for the medicament which is administrated from peripheral veins to enter the systemic circulation. For criticalpatients who cannot be treated by regular vein puncture, the intra-bone marrow transfusion may be a first choice instead of the traditional venous transfusion is quick, safe and effective rescue technology and saves precious time for life rescue. In the invention, a medullo-puncture needle is penetrated into the marrow cavity by a mechanical energy releasing device to feed the medicament and the liquid into the veins. The disposable intra-bone marrow injection device drives the medullo-puncture needle into the intra-bone marrow by the mechanical energy released by winded clockwork springs.

The invention relates to an externally embedded photoelectric detection drip transfusion controller which comprises a host computer, and an externally embedded photoelectric detection shutter connected with the host computer, wherein the host computer comprises a host computer shell and a host computer electric assembly, the host computer electric assembly comprises a battery, a power supply switch, a work switch, a function switching switch, a host computer circuit board, a host computer five-pin socket and a buzzer, the host computer circuit board is provided with a monitoring circuit and a liquid circuit shutter control circuit; and the externally embedded photoelectric detection shutter comprises a shutter shell, an electric connecting combination board, an electromagnetic suction coil, a photoelectric detection switch, a five-core flat wire plug, a five-core flat wire and a shutting liquid path mechanical assembly, and the shutting liquid path mechanical assembly comprises a main conical spring, a damping force spring piece, a built-up connection mother board, a two-head oscillating bar, a swinging armature and a transmission and lock controlling shutting liquid path executing mechanism. The invention integrates electricity with machinery into a whole, and has functions of real-time monitoring, sound reminding and timing shutting on the clinical central vein infusion.

The invention discloses a disposable automatic exhausting and liquid stopping infusion device and a method. The infusion device comprises an upper cavity of the infusion device and a lower cavity of the infusion device. The upper cavity of the infusion device and the lower cavity of the infusion device are connected in an embedded mode and are connected in a sealed mode. An air filtering membrane is designed at the upper portion in an inner cavity formed by the upper cavity of the infusion device and the lower cavity of the infusion device, and a liquid medicine splitter plate is installed below the air filtering membrane. A liquid medicine filtering membrane is arranged at the upper end of the lower cavity of the infusion device, a liquid stopping floating piece can be installed at the lower end of the lower cavity of the infusion device, and a liquid outlet connector is connected to the liquid outlet position of the lower cavity of the infusion device. According to the disposable automatic exhausting and liquid stopping infusion device and the method, under the splitting and stressing action of the liquid medicine splitter plate, residual air bubbles of liquid medicine are filtered out and eliminated through the air filtering mebrane and an exhaust opening formed in the upper cavity of the infusion device. The disposable automatic exhausting and liquid stopping infusion device and the method can be widely applied to infusion of clinic center venous catheters, periphery intervention central veins and the like.

The invention discloses an accurate printing construction method for a liver unit chip containing an acinus three-vessel structure, and belongs to the field of microfluidic technologies, tissue engineering and biological three-dimensional (3D) printing. According to the method, hydrogel containing cells constructs a liver tissue model in a microfluidic chip through a biological 3D printer, and theliver cell hydrogel model is subjected to perfusion culture through structural design of the microfluidic chip to simulate the liver microenvironment of a human body; and the chip comprises multiplelayers and contains three types of different micro-channel structures so as to reproduce a three-vessel system of the hepatic arteries, portal veins and central veins in liver lobules. The accurate printing construction method provides a more accurate analytical testing platform for drug development and liver drug toxicity testing.

The invention provides a central vein catheter, and relates to the technical field of medical apparatus and instruments. The central vein catheter comprises a main catheter body, at least one branch pipe and at least one extension pipe; the main catheter body is internally provided with at least one passage extending in the axial direction of the passage; the outlet end of any one branch pipe is communicated with the corresponding passage, and the inlet end of any one branch pipe is communicated with the corresponding extension pipe; a sub connector is arranged at the inlet end of each branchpipe, and an outer connector cooperating with the corresponding sub connector is arranged at the inlet end of each extension pipe; the sub connectors and the outer connectors are adjusted, and the branch pipes and the extension pipes are conducted or blocked or separated. According to the central vein catheter, conduction and blocking of the central vein catheter are achieved by means of the sub connectors and the outer connectors, a traditional stop clamp is replaced, breakage risk of the central vein catheter can be eradicated, the probability of medical negligence is lowered, and the service life of the medical apparatus and instruments is prolonged.

The invention provides a tissue engineering artificial liver-like tissue construction mold and a method for manufacturing the tissue engineering artificial liver-like tissue construction mold. The tissue engineering artificial liver-like tissue construction mold comprises a mold main body, a first height-increasing body and a second height-increasing body, wherein the first height-increasing bodyand the second height-increasing body are matched with the mold main body, the first height-increasing body is placed on the mold main body and is used for increasing the capacity of the mold main body so as to inoculate micro liver cells, and the second height-increasing body is used for fixing a dialysis membrane and separating a cell sodium alginate suspension from an upper layer calcium chloride solution, wherein the calcium chloride solution is added to the upper layer of the dialysis membrane, and the calcium ions can penetrate through the dialysis membrane so as to achieve the gelatinous sodium alginate. Compared to the mold in the prior art, the tissue engineering artificial liver-like tissue construction mold of the present invention has the following characteristic that the aggregated cells are re-assembled by the tissue engineering artificial liver-like tissue construction mold to make the aggregated cells be distributed and arranged in a hepatic lobule imitating hexagon manner, such that the gaps similar to the portal area, the central vein and the liver sinusoid are formed between the micro liver cells so as to easily achieve the in vivo vascularization process and improve the efficacy of the liver cells per unit volume, and so as not to affect the substance exchange efficiency.

The invention provides an in-vivo enrichment device of circulating free DNA. The device comprises a conduit body which can reach a central vein through peripheral vein puncture, wherein multiple sieve holes are distributed in the wall of the conduit body; the conduit body is filled with magnetic beads which have specific binding with the circulating free DNA; and the front end of the conduit body is a blind end. According to the in-vivo enrichment device provided by the invention, the conduit body is filled with the magnetic beads which have specific binding with the circulating free DNA, and the sieve holes are formed in the conduit wall of the conduit body, so ccfDNA in blood is continuously bound specifically to the magnetic beads inside the conduit body, so efficient and high-quality capture of the ccfDNA in bloods can be achieved. The device provided by the invention is characterized by in-vivo use, efficient capture and clinical portable application; molecule gene diagnosis information based on ccfDNA can be provided for earlier tumor diagnosis, targeted therapy, relapse transfer detection, treatment effect assessment and so forth, and application prospect is very wide.

The invention provides a central vein puncturing stent under ultrasonic guiding. The central vein puncturing stent under ultrasonic guiding comprises a pasting part and an adsorbing part, wherein the pasting part is formed by an upper side surface, a lower side surface, a front side surface, a back side surface and a left side surface in a surrounding manner; a run-through circular hole is formed in the upper side surface; a run-through long square hole is formed in the lower side surface; a run-through hollow structure is arranged in the pasting part; a cover plate covers the right side of the pasting part and is detachably connected with the pasting part; a balloon is arranged on one side of the side plate and far from the pasting part; and a hard ring is arranged at the lower end of the balloon and is flush with the lower side surface of the pasting part. Compared with the prior art, the central vein puncturing stent under ultrasonic guiding provided by the invention has the sticky pasting part and the adsorbing part capable of generating negative pressure; an ultrasonic probe is placed in the pasting part; the whole apparatus is tightly fitted with skin in a vein puncturing region under the effects of sticking and negative pressure; and vein collapse can be avoided in central vein puncturing by lifting the apparatus upwardly.

The invention discloses a catheter bed of a peripherally inserted central vein catheter. The catheter bed of peripherally inserted central vein catheter comprises a bed body, a sliding mechanism, a turning mechanism, a telescopic mechanism, a pallet, a restraining device and a fastener; the sliding mechanism is installed at a bottom edge position of the bed body, and the sliding mechanism is fixedby a locking device; the turning mechanism is fixed on a sliding portion of the sliding mechanism; the telescopic mechanism is fixed at a movable end of the turning mechanism, The catheter bed has the following advantages: a slide block slides along a slide rail to adjust the lateral support position of the pallet, a telescopic rod drives a mounting seat to perform telescopic movement for adjusting a supporting height of the pallet, the adjustment is convenient, and is convenient for adapting to patients of different body types, the patient's arm is placed in the most appropriate position aspossible when placed on the pallet, which reduces the patient's pain.

The present invention relates to a medicine composition, preparation method and its application. The described medicine composition contains salvia root and peony root for preventing and curing diabetes and complicating diseases, senile dementia, angiocardiopathy, cerebrovascular diseases, hyperlipemia, fatty liver and thrombosis of central vein of retina.

The invention concerns a multi purpose puncture drainage device for transferal of human body medium. The main body of the puncture drainage device is a slim soft tube, on one end of which, a cone-shaped body is provided, the front end of the cone opens, and a plurality of side holes are provided on the rear end of cone tube, while on the other end of the slim soft tube, a multiport valve is installed, connecting with a main port and a side port on its valve body. The invention can be used as special puncture drainage device for draining body cavity dropsy, hematocele and pneumatosis . It can also be applied for transfusion for central vein liquid transfusion, blood transfusion, pressure measurement and treatment.

The present invention relates to a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme as an active ingredient, more precisely a pharmaceutical composition for treating liver dysfunction which contains arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects liver by inhibiting liver injury around central vein region. Therefore, the arazyme of the invention can be effectively used as a pharmaceutical composition for the prevention of liver dysfunction.

The invention relates to the technical field of medical equipment, in particular to a disposable central vein puncture kit. At present, after a puncture needle penetrates through a central vein, a guide steel wire is arranged, the puncture needle is withdrawn, the skin is expanded through a skin expander, and a central vein catheter is arranged along the guide steel wire during domestic venous transfusion cathetering. The defects are that 1, the guide steel wire possibly touches the heart, so that arrhythmia is caused; 2, the skin is expanded through the skin expander, so that the guide steel wire is possibly bent, the catheter is difficult to arrange, and puncture fails; and 3, the catheter is thick, and the central venous catheter related infection probability is high. The disposable central vein puncture kit comprises a central vein catheter and a puncture needle, wherein a catheter sheath is arranged outside the puncture needle and has an easily torn breakage indentation. During use, the central vein catheter is arranged through the catheter sheath. The operation is easy, the guide steel wire is not required, the skin is not required to be expanded, the injury of a patient is lightened to a certain degree, and the related infection occurrence rate of the catheter is reduced.

The present invention provides a compound amino acid injection for curing nephropathy. The present invention is added with tyrosine and typtophane, the demand of which increases in kidney failure, as well as nine unnecessary amino acids, such as arginine which plays an important role in promoting urea circulation and balancing blood amino acid density; the non-protein heat / nitrogen (NPC / N) ratio is decreased from 500 to 1,000 in the past to 300 to 400 or so; the proportion between necessary amino acids and unnecessary amino acids is 3 to 4, thus reducing the weight parts of lysine, methionine, phenylalanine, threonine and histidine which can easily increase the blood concentration when the kidney necessary amino acid preparation is in use. The acid injection of the present invention not only has the effect of the original kidney amino acid preparation of maintaining the kidney function and improving uremia, but also has the obvious effect of improving the nutrition by medication from peripheral vein or central vein.