71 results about "Central veins" patented technology

The invention belongs to the medical teaching equipment technical field and relates to a fully-automatic multi-functional integrated puncture training computer dummy. The fully-automatic multi-functional integrated puncture training computer dummy comprises a high-simulation human body model, a position-automatic changing experimental table, puncture cavities, modules, arteriovenous veins, a liquid injection automatic control device, a fully-automatic arterial pulse simulator and a microcomputer controller. The dummy is characterized in that the high-simulation human body model is installed on the position-automatic changing position experimental table and is provided with various puncture cavities / modules such as pneumothorax, hydrothorax and abdominocentesis modules which are all connected with the microcomputer controller and / or a micro water pump / air pump; double-layer metal mesh electrodes are distributed on the neck, thoracic puncture and lumbar puncture positions of the dummy; the dummy is further provided with kidney, bladder, lymph gland and bone marrow puncture cavities / modules as well as a variety of puncturable central veins and peripheral veins; and arteries are connected with a fully-automatic blood circulation simulator. With the dummy adopted, dozens of puncture items can be provided; puncture position change, liquid injection, gas injection and artery pulsing are completely automated; and sound-light alarms can be given out automatically; life-like simulation effects can be realized; and teaching effects can be significantly improved.

In emergency, the optimal method for building an emergency transfusion channel is intra-bone marrow transfusion which ensures that a medicament and liquid transfused into the marrow cavity can quickly and effectively enter blood circulation. The time for the medicament administrated from intra-bone marrow to enter systemic circulation is basically the same as that for the medicament which is administrated from central veins to enter the systemic circulation, but is quicker than that for the medicament which is administrated from peripheral veins to enter the systemic circulation. For criticalpatients who cannot be treated by regular vein puncture, the intra-bone marrow transfusion may be a first choice instead of the traditional venous transfusion is quick, safe and effective rescue technology and saves precious time for life rescue. In the invention, a medullo-puncture needle is penetrated into the marrow cavity by a mechanical energy releasing device to feed the medicament and the liquid into the veins. The disposable intra-bone marrow injection device drives the medullo-puncture needle into the intra-bone marrow by the mechanical energy released by winded clockwork springs.

The invention relates to an externally embedded photoelectric detection drip transfusion controller which comprises a host computer, and an externally embedded photoelectric detection shutter connected with the host computer, wherein the host computer comprises a host computer shell and a host computer electric assembly, the host computer electric assembly comprises a battery, a power supply switch, a work switch, a function switching switch, a host computer circuit board, a host computer five-pin socket and a buzzer, the host computer circuit board is provided with a monitoring circuit and a liquid circuit shutter control circuit; and the externally embedded photoelectric detection shutter comprises a shutter shell, an electric connecting combination board, an electromagnetic suction coil, a photoelectric detection switch, a five-core flat wire plug, a five-core flat wire and a shutting liquid path mechanical assembly, and the shutting liquid path mechanical assembly comprises a main conical spring, a damping force spring piece, a built-up connection mother board, a two-head oscillating bar, a swinging armature and a transmission and lock controlling shutting liquid path executing mechanism. The invention integrates electricity with machinery into a whole, and has functions of real-time monitoring, sound reminding and timing shutting on the clinical central vein infusion.

The invention discloses an accurate printing construction method for a liver unit chip containing an acinus three-vessel structure, and belongs to the field of microfluidic technologies, tissue engineering and biological three-dimensional (3D) printing. According to the method, hydrogel containing cells constructs a liver tissue model in a microfluidic chip through a biological 3D printer, and theliver cell hydrogel model is subjected to perfusion culture through structural design of the microfluidic chip to simulate the liver microenvironment of a human body; and the chip comprises multiplelayers and contains three types of different micro-channel structures so as to reproduce a three-vessel system of the hepatic arteries, portal veins and central veins in liver lobules. The accurate printing construction method provides a more accurate analytical testing platform for drug development and liver drug toxicity testing.

The invention provides a tissue engineering artificial liver-like tissue construction mold and a method for manufacturing the tissue engineering artificial liver-like tissue construction mold. The tissue engineering artificial liver-like tissue construction mold comprises a mold main body, a first height-increasing body and a second height-increasing body, wherein the first height-increasing bodyand the second height-increasing body are matched with the mold main body, the first height-increasing body is placed on the mold main body and is used for increasing the capacity of the mold main body so as to inoculate micro liver cells, and the second height-increasing body is used for fixing a dialysis membrane and separating a cell sodium alginate suspension from an upper layer calcium chloride solution, wherein the calcium chloride solution is added to the upper layer of the dialysis membrane, and the calcium ions can penetrate through the dialysis membrane so as to achieve the gelatinous sodium alginate. Compared to the mold in the prior art, the tissue engineering artificial liver-like tissue construction mold of the present invention has the following characteristic that the aggregated cells are re-assembled by the tissue engineering artificial liver-like tissue construction mold to make the aggregated cells be distributed and arranged in a hepatic lobule imitating hexagon manner, such that the gaps similar to the portal area, the central vein and the liver sinusoid are formed between the micro liver cells so as to easily achieve the in vivo vascularization process and improve the efficacy of the liver cells per unit volume, and so as not to affect the substance exchange efficiency.

In emergency, the optimal method for building an emergency transfusion channel is intra-bone marrow transfusion which ensures that a medicament and liquid transfused into the marrow cavity can quickly and effectively enter blood circulation. The time for the medicament administrated from intra-bone marrow to enter systemic circulation is basically the same as that for the medicament which is administrated from central veins to enter the systemic circulation, but is quicker than that for the medicament which is administrated from peripheral veins to enter the systemic circulation. For critical patients who cannot be treated by regular vein puncture, the intra-bone marrow transfusion may be a first choice instead of the traditional venous transfusion is quick, safe and effective rescue technology and saves precious time for life rescue. In the invention, a medullo-puncture needle is penetrated into the marrow cavity by a mechanical energy releasing device to feed the medicament and the liquid into the veins. The disposable intra-bone marrow injection device drives the medullo-puncture needle into the intra-bone marrow by the mechanical energy released by winded clockwork springs.

The invention provides an in-vivo enrichment device of circulating free DNA. The device comprises a conduit body which can reach a central vein through peripheral vein puncture, wherein multiple sieve holes are distributed in the wall of the conduit body; the conduit body is filled with magnetic beads which have specific binding with the circulating free DNA; and the front end of the conduit body is a blind end. According to the in-vivo enrichment device provided by the invention, the conduit body is filled with the magnetic beads which have specific binding with the circulating free DNA, and the sieve holes are formed in the conduit wall of the conduit body, so ccfDNA in blood is continuously bound specifically to the magnetic beads inside the conduit body, so efficient and high-quality capture of the ccfDNA in bloods can be achieved. The device provided by the invention is characterized by in-vivo use, efficient capture and clinical portable application; molecule gene diagnosis information based on ccfDNA can be provided for earlier tumor diagnosis, targeted therapy, relapse transfer detection, treatment effect assessment and so forth, and application prospect is very wide.

The present invention relates to a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme as an active ingredient, more precisely a pharmaceutical composition for treating liver dysfunction which contains arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects liver by inhibiting liver injury around central vein region. Therefore, the arazyme of the invention can be effectively used as a pharmaceutical composition for the prevention of liver dysfunction.